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The map label for this gene is dctA [H]

Identifier: 148823645

GI number: 148823645

Start: 2755383

End: 2756858

Strand: Direct

Name: dctA [H]

Synonym: TBFG_12470

Alternate gene names: 148823645

Gene position: 2755383-2756858 (Clockwise)

Preceding gene: 148823639

Following gene: 148823652

Centisome position: 62.28

GC content: 63.28

Gene sequence:

>1476_bases
ATGACCGCCCCCTTGGATCGTGCGCCGGTCACGGATTTGCCGGCTAACAACAAAGGCCGAGACCGCACCCACTGGCTGTA
TCTCGCGGTCATTTTCGCAGTGATAGCCGGTGTGATCGTGGGGCTGACGGCGCCGTCGACCGGAAAAAGCCTCACGGTGC
TCGGGACGGTGTTCGTCAACCTGATCAAGATGATGATCGCACCGGTCATCTTCTGCACGATCGTGCTCGGGATCGGCTCG
GTGCGCAAAGCCGCGGCCGTGGGCAAGGTCGGCGGGCTGGCTTTGGCCTACTTTCTAACGATGTCATCGGTGGCGCTCGG
GATCGGGTTGATCGTCGGCAACCTACTCAGTCCGGGTAGGGATCTGCACCTTAGGCCTGGTGCGGTCGGAAGCGGCGCAG
CATTGGCCGGCCAGGCTGCGGAGTCACACGGAATCGCTGGGTTCATCCAGCAGATCATTCCGAGGTCGCTCCCCTCAGCC
CTTACTGAAGGCAACGTGCTGCAGGTGTTACTCGTCGCGCTGCTGGTCGGTTTCGCGGTCCAAGGCCTGGGCCCCGCAGG
CGAGTCCATCCTGCGTGCCGTCGAGAACCTGCAAAAGCTGGTGTTCAAGGTGCTCGTGATGGTACTGTGGCTGGCTCCGA
TCGGCGCGTTCGGTGCGATCGCCAATATCGTCGCCACGACTGGCTTCAACGCCGTCACCAACCTGCTGCTGCTGATGGCC
GGCTTCTACCTGACGTGCGTGGTGTTCGTTTTCGGCGTCCTGGGAGTGCTACTGCGCATCGTGTCGGGTTTGTCGATCTT
TCGGCTGCTGCGCTATCTAGCCCGCGAGTACTTGCTGATCTTCGCAACATCGTCGTCGGAGGTGGTGCTGCCCAGACTGA
TCACCAAGATGAAACACTTGGGCGTGCAATCCAGCACGGTCGGCGTGGTGGTGCCGACCGGCTACTCGTTCAATCTTGAC
GGCACCGCTATCTATCTGACCATGGCGTCGCTGTTCATCGCCGACGCGATGGGACATCGCTTGACATGGGGCGAGCAGAT
CGCGCTGCTGGCGTTCATGATCATCGCGTCCAAGGGCGCTGCCGGGGTCAGCGGTGCGGGCCTTGCGACGCTGGCCGGCG
GCCTGCAGGCTCATCGCCCCGAGCTGCTGGACGGTGTCGGGCTGATTGTGGGGATCGACCGGTTCATGTCGGAAGCCCGT
TCGCTCACGAACTTCTCCGGCAACGCCGTCGCAACCATCCTGGTTGCCTCGTGGACAAAGACCATTGACCTGTCCAAAGC
CGACGAGGTGTTGCGCGGTCGTGATCCCTTCGACGAATCGACCATGGTCGATCCCCACGATGAGGAGCCACCCGCCGCCA
CACCCCACGGGGGCGGCGTCCCGACGAACCCTGCGCTGTGCGATTTCGAGCAGGTCAGTCTAGGCGGATTGGTGGGCCGG
CCGGCCGGCCCGCAACGCGCCGACGTGGACGGGTAG

Upstream 100 bases:

>100_bases
CTCCGGGGCCCGGGTGGTGACGTCATCCGGGTTGGACCGCTGATGGCTGCGGCTAACATCGTGCCGAATCGCGTCCGATG
TCGATCTGGAGGAACCGCCG

Downstream 100 bases:

>100_bases
GGGCCAGCTCCGTGACACCGGGGACGTCGACTTCGCCCGGGGAACCGTCCAAGCCGGCTGCATCCTCCTCGTCGACGTCG
GCATCGGCGGCGTCTTCGTC

Product: C4-dicarboxylate-transport transmembrane protein dctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKSLTVLGTVFVNLIKMMIAPVIFCTIVLGIGS
VRKAAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQQIIPRSLPSA
LTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMA
GFYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGYSFNLD
GTAIYLTMASLFIADAMGHRLTWGEQIALLAFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEAR
SLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGR
PAGPQRADVDG

Sequences:

>Translated_491_residues
MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKSLTVLGTVFVNLIKMMIAPVIFCTIVLGIGS
VRKAAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQQIIPRSLPSA
LTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMA
GFYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGYSFNLD
GTAIYLTMASLFIADAMGHRLTWGEQIALLAFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEAR
SLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGR
PAGPQRADVDG
>Mature_490_residues
TAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKSLTVLGTVFVNLIKMMIAPVIFCTIVLGIGSV
RKAAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQQIIPRSLPSAL
TEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAG
FYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGYSFNLDG
TAIYLTMASLFIADAMGHRLTWGEQIALLAFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEARS
LTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGRP
AGPQRADVDG

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=489, Percent_Identity=23.5173824130879, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI21314632, Length=405, Percent_Identity=24.4444444444444, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI5032093, Length=428, Percent_Identity=24.2990654205607, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI223468564, Length=302, Percent_Identity=24.5033112582781, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI223468566, Length=302, Percent_Identity=24.5033112582781, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI66773030, Length=321, Percent_Identity=27.1028037383178, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI40254478, Length=487, Percent_Identity=21.5605749486653, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI194239697, Length=271, Percent_Identity=27.3062730627306, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4827012, Length=270, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI262359914, Length=390, Percent_Identity=22.0512820512821, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=47.1014492753623, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=33.4140435835351, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1788024, Length=403, Percent_Identity=25.0620347394541, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789473, Length=324, Percent_Identity=26.2345679012346, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=446, Percent_Identity=25.5605381165919, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983099, Length=467, Percent_Identity=23.5546038543897, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=467, Percent_Identity=23.5546038543897, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=483, Percent_Identity=23.6024844720497, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71996953, Length=477, Percent_Identity=23.0607966457023, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193206505, Length=468, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583025, Length=482, Percent_Identity=25.3112033195021, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17137668, Length=482, Percent_Identity=25.3112033195021, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24583023, Length=482, Percent_Identity=25.3112033195021, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI281360483, Length=480, Percent_Identity=24.5833333333333, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137666, Length=480, Percent_Identity=24.5833333333333, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281360481, Length=480, Percent_Identity=24.5833333333333, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 50989; Mature: 50858

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCC
>Mature Secondary Structure 
TAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKSLTVLGTVFVN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLHLRPGAVGSGAALAGQAAESHGIAGFIQQIIPRSLPSALTEGNVLQVLLVALLVGFAV
CEEECCCCCCCCCHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QGLGPAGESILRAVENLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMA
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GFYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHC
GVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGEQIALLAFMIIASKGA
CCCCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
AGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEARSLTNFSGNAVATILVASWTK
CCCCCCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TIDLSKADEVLRGRDPFDESTMVDPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGR
HCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
PAGPQRADVDG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA