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The map label for this gene is rnz

Identifier: 148823610

GI number: 148823610

Start: 2719350

End: 2720192

Strand: Direct

Name: rnz

Synonym: TBFG_12435

Alternate gene names: 148823610

Gene position: 2719350-2720192 (Clockwise)

Preceding gene: 148823607

Following gene: 148823611

Centisome position: 61.46

GC content: 65.95

Gene sequence:

>843_bases
ATGCTTGAGATCACGTTGCTCGGAACTGGGAGCCCCATTCCCGACCCGGACCGTGCCGGACCATCCACTCTGGTGCGGGC
CGGCGCGCAGGCGTTCCTGGTGGACTGCGGTCGCGGCGTGCTGCAACGCGCGGCGGCCGTCGGTGTGGGCGCCGCAGGAT
TGTCGGCGGTGCTGCTCACCCATTTACACAGCGACCATATCGCCGAGCTCGGCGACGTGCTTATCACCAGTTGGGTCACC
AACTTCGCTGCTGATCCCGCGCCCTTGCCGATCATCGGACCGCCGGGCACCGCCGAAGTGGTGGAGGCGACGTTGAAGGC
ATTCGGTCACGACATCGGCTATCGGATCGCCCACCACGCCGATCTGACGACACCACCACCGATCGAGGTGCACGAATACA
CCGCAGGCCCAGCTTGGGATCGCGACGGCGTGACAATCCGGGTGGCCCCTACCGATCATCGGCCGGTCACGCCGACGATC
GGATTCCGGATCGAATCCGACGGTGCTTCGGTGGTGCTCGCCGGTGACACCGTTCCTTGTGACAGCCTCGACCAGCTGGC
CGCCGGAGCGGATGCGTTGGTACACACGGTGATCCGCAAAGACATCGTCACGCAGATCCCGCAGCAACGGGTCAAGGACA
TCTGCGATTACCACTCGTCGGTGCAGGAAGCCGCCGCAACCGCGAACCGCGCAGGGGTGGGAACCCTGGTCATGACGCAC
TATGTGCCGGCTATCGGGCCCGGACAAGAAGAACAGTGGCGGGCGCTGGCCGCGACCGAGTTCAGCGGGCGGATCGAGGT
CGGCAACGACCTACACCGAGTCGAGGTGCACCCGCGGCGCTAG

Upstream 100 bases:

>100_bases
CGCCCATGTCGGCCGCATCCTCGAGGCTAAAACTCGTTGGCCATCAGCCGAATCGGTCGATCGGGGCCGCTGGATCCATC
GAGCTTGTCAGGATAGGGCC

Downstream 100 bases:

>100_bases
CACGCCAGCTATGACCAACCAGCCCCGACACCAGGGCGATCGATAAGGCAAGAAGTAGATCGCCCGAACCAGCGCCGGGT
CCGTGCTGACCCTCGGGCGC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLTHLHSDHIAELGDVLITSWVT
NFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHADLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTI
GFRIESDGASVVLAGDTVPCDSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAAATANRAGVGTLVMTH
YVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR

Sequences:

>Translated_280_residues
MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLTHLHSDHIAELGDVLITSWVT
NFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHADLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTI
GFRIESDGASVVLAGDTVPCDSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAAATANRAGVGTLVMTH
YVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR
>Mature_280_residues
MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLTHLHSDHIAELGDVLITSWVT
NFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHADLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTI
GFRIESDGASVVLAGDTVPCDSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAAATANRAGVGTLVMTH
YVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_MYCBO (Q7TYN1)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_856079.1
- ProteinModelPortal:   Q7TYN1
- SMR:   Q7TYN1
- EnsemblBacteria:   EBMYCT00000016150
- GeneID:   1094283
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2430
- GeneTree:   EBGT00050000017432
- HOGENOM:   HBG648406
- OMA:   VWDRDGV
- ProtClustDB:   PRK00055
- BioCyc:   MBOV233413:MB2430-MONOMER
- BRENDA:   3.1.26.11
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 29473; Mature: 29473

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLT
CEEEEEEECCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
HLHSDHIAELGDVLITSWVTNFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHEEECC
DLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTIGFRIESDGASVVLAGDTVPC
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCC
DSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAAATANRAGVGTLVMTH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
YVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR
HCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEEECCCC
>Mature Secondary Structure
MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRAAAVGVGAAGLSAVLLT
CEEEEEEECCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
HLHSDHIAELGDVLITSWVTNFAADPAPLPIIGPPGTAEVVEATLKAFGHDIGYRIAHHA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHEEECC
DLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTIGFRIESDGASVVLAGDTVPC
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCC
DSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAAATANRAGVGTLVMTH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
YVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR
HCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972