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The map label for this gene is ybeX [C]

Identifier: 148823569

GI number: 148823569

Start: 2660355

End: 2661662

Strand: Reverse

Name: ybeX [C]

Synonym: TBFG_12392

Alternate gene names: 148823569

Gene position: 2661662-2660355 (Counterclockwise)

Preceding gene: 148823570

Following gene: 148823568

Centisome position: 60.16

GC content: 64.98

Gene sequence:

>1308_bases
TTGACCGGGTACTACCAGCTGCTCGGCTCGATCGTATTGATCGGTTTGGGTGGGTTGTTCGCCGCGATTGACGCCGCCAT
CAGCACCGTGTCTCCGGCCCGGGTGGATGAGCTAGTACGCGACCAGCGGCCGGGCGCGGGGTCGCTGCGTAAGGTGATGG
CCGACCGGCCGCGGTACGTCAACCTGGTCGTGTTGCTGCGGACCAGCTGTGAGATCACCGCGACCGCGCTGCTGGTGGTT
TTCATCCGATACCACTTCAGCATGGTGTGGGGGTTGTATCTTGCCGCGGGCATCATGGTTTTGGCCAGCTTTGTCGTCGT
GGGAGTGGGGCCACGCACCCTTGGGCGCCAGAACGCATATTCCATCTCGTTGGCCACGGCCCTTCCGCTGCGGCTGATCT
CGTGGTTGTTGATGCCGATCAGCCGCTTGCTGGTGTTGCTGGGCAACGCACTGACCCCCGGGCGCGGCTTTCGCAACGGG
CCGTTTGCATCCGAGATCGAGCTGCGCGAAGTTGTCGACCTAGCCCAGCAGCGGGGCGTGGTTGCTGCCGACGAGCGCCG
GATGATCGAGTCGGTCTTCGAGCTGGGTGACACCCCAGCCCGCGAGGTGATGGTGCCGCGCACCGAGATGATCTGGATCG
AAAGCGACAAGACAGCCGGTCAAGCAATGACCCTGGCGGTACGCAGCGGACATTCCCGAATCCCGGTGATCGGCGAGAAC
GTCGACGACATCGTCGGCGTGGTGTACCTGAAAGACCTTGTCGAGCAGACGTTCTGCTCGACGAACGGCGGCCGCGAAAC
GACCGTCGCGCGGGTGATGCGGCCAGCTGTGTTCGTGCCGGACTCCAAGCCGCTGGACGCATTGCTGCGGGAAATGCAGC
GCGACCGTAACCACATGGCCCTGCTGGTCGACGAGTACGGCGCGATAGCCGGCCTCGTCAGCATCGAAGACGTGCTGGAG
GAGATCGTCGGCGAGATTGCCGACGAGTACGACCAGGCCGAGACGGCGCCGGTGGAAGACTTGGGCGACAAGCGTTTCCG
GGTATCGGCGCGCCTGCCCATCGAAGACGTCGGCGAGCTGTACGGCGTGGAGTTCGACGACGACCTTGACGTCGACACGG
TGGGCGGGCTGCTGGCCCTAGAACTGGGCCGGGTGCCGCTGCCCGGCGCTGAGGTGATATCGCATGGCCTGCGGCTGCAT
GCCGAGGGTGGCACCGATCATCGGGGACGGGTACGAATCGGCACCGTGTTGCTGAGTCCGGCCGAACCCGACGGCGCCGA
TGATGAGGAGGCCGATCACCCTGGCTGA

Upstream 100 bases:

>100_bases
TGCTTGAAGAGTGGGTAGCCGACCAGGTTGAGGCCTACCAGCACGACCGGCAGGACGAGAAGGACCGCCGGTTGCTCGAC
AAGTCAAGGTATTTTGACCT

Downstream 100 bases:

>100_bases
GCAGCTAGATGCCGAGGACGCAAAGCTGGTTGTGTTGGCACGGGCGGCGATGGCACGTGCCGAGGCCGGTGCCGGCGCGG
CGGTCCGCGATGTCGACGGC

Product: transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVV
FIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNG
PFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGEN
VDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLE
EIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLH
AEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG

Sequences:

>Translated_435_residues
MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVV
FIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNG
PFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGEN
VDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLE
EIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLH
AEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG
>Mature_434_residues
TGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVF
IRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGP
FASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGENV
DDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEE
IVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHA
EGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI310128564, Length=391, Percent_Identity=25.3196930946292, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI94681046, Length=339, Percent_Identity=25.3687315634218, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40068049, Length=154, Percent_Identity=33.7662337662338, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI40068053, Length=206, Percent_Identity=27.1844660194175, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI40068055, Length=206, Percent_Identity=27.1844660194175, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786879, Length=216, Percent_Identity=38.4259259259259, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI145693175, Length=382, Percent_Identity=24.6073298429319, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87082033, Length=262, Percent_Identity=27.4809160305344, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790664, Length=371, Percent_Identity=22.3719676549865, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788119, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2366_MYCTU (P67130)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   E70586
- RefSeq:   NP_216882.1
- RefSeq:   NP_336915.1
- ProteinModelPortal:   P67130
- EnsemblBacteria:   EBMYCT00000000599
- EnsemblBacteria:   EBMYCT00000071093
- GeneID:   885987
- GeneID:   925915
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2435
- KEGG:   mtu:Rv2366c
- TIGR:   MT2435
- TubercuList:   Rv2366c
- GeneTree:   EBGT00050000016975
- HOGENOM:   HBG673071
- OMA:   CEVSATV
- ProtClustDB:   CLSK872055
- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21

EC number: NA

Molecular weight: Translated: 47214; Mature: 47083

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1b57a63c)-; HASH(0x1bc0add8)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCE
NLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAY
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCE
SISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGV
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
VAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGEN
EEHHHHHHHHHHHHCCCCCCHHEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCEECCC
VDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCEE
LLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGEL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEECCCHHHHHHH
YGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSP
HCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEECCCCCCCCEEEEEEEEEEC
AEPDGADDEEADHPG
CCCCCCCCCCCCCCH
>Mature Secondary Structure 
TGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCE
NLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAY
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCE
SISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGV
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
VAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGEN
EEHHHHHHHHHHHHCCCCCCHHEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCEECCC
VDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCEE
LLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGEL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEECCCHHHHHHH
YGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSP
HCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEECCCCCCCCEEEEEEEEEEC
AEPDGADDEEADHPG
CCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036