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The map label for this gene is yjcE [C]

Identifier: 148823488

GI number: 148823488

Start: 2570491

End: 2572119

Strand: Direct

Name: yjcE [C]

Synonym: TBFG_12309

Alternate gene names: 148823488

Gene position: 2570491-2572119 (Clockwise)

Preceding gene: 148823486

Following gene: 148823489

Centisome position: 58.1

GC content: 65.87

Gene sequence:

>1629_bases
ATGAATGGTCGACGCACCATAGGCGAGGATGGGCTGGTGTTCGGGCTCGTCGTTATCGTTGCGCTGGTCGCCGCCGTGGT
CGTGGGGACCGTCCTGGGCCACCGCTATCGCGTGGGCCCTCCAGTGTTGCTCATCCTGTCCGGTTCCCTGCTGGGTCTGA
TTCCCCGTTTCGGTGACGTTCAGATCGATGGCGAGGTGGTGCTGCTGCTGTTCCTGCCGGCGATCCTTTATTGGGAGAGC
ATGAACACCAGCTTTCGCGAGATCCGCTGGAACCTGCGCGTCATCGTCATGTTCAGTATCGGGCTGGTGATTGCCACCGC
GGTCGCGGTGTCGTGGACGGCACGAGCGCTGGGCATGGAGTCCCACGCCGCGGCTGTCCTCGGTGCCGTGCTCTCCCCCA
CCGATGCCGCGGCGGTGGCCGGCCTGGCGAAACGGTTGCCGCGCCGGGCGCTGACAGTGCTACGCGGCGAGAGCCTCATC
AACGACGGGACCGCGCTCGTGCTGTTCGCCGTCACCGTGGCGGTCGCGGAAGGTGCCGCTGGGATCGGCCCGGCCGCGCT
GGTCGGCCGGTTCGTCGTCTCCTATCTCGGCGGAATCATGGCCGGGCTGCTGGTCGGCGGCCTGGTGACATTGCTACGCC
GCAGAATCGACGCACCATTGGAGGAGGGAGCCCTGAGCTTGCTGACGCCGTTCGCAGCGTTCTTGCTCGCTCAATCTCTG
AAGTGCAGCGGTGTGGTTGCGGTGCTGGTTTCGGCCCTGGTCCTCACCTACGTTGGTCCGACGGTGATACGCGCTCGTTC
CCGCCTGCAGGCGCATGCGTTTTGGGACATCGCCACGTTCCTGATCAACGGCTCGTTGTGGGTGTTTGTCGGCGTCCAGA
TCCCGGGCGCGATAGACCACATCGCCGGCGAGGACGGGGGACTACCACGGGCCACAGTCCTGGCCCTGGCGGTGACGGGT
GTCGTTATCGCCACCCGGATCGCCTGGGTACAGGCAACCACGGTCCTGGGTCACACCGTGGACCGGGTCCTGAAGAAGCC
CACCCGCCACGTCGGCTTCCGTCAGCGTTGCGTCACAAGCTGGGCCGGTTTCCGCGGCGCGGTATCGCTTGCCGCAGCGC
TGGCGGTGCCGATGACCACCAATAGCGGCGCTCCATTCCCAGACCGCAACCTGATCATCTTCGTCGTCTCGGTCGTCATT
CTGGTCACCGTGCTGGTCCAAGGGACTTCCTTGCCCACCGTCGTTCGGTGGGCGAGGATGCCCGAAGACGTCGCGCACGC
CAACGAATTGCAGCTGGCCCGCACCCGTAGCGCCCAAGCCGCCCTCGACGCTTTGCCGACGGTCGCCGACGAACTCGGGG
TCGCCCCCGATCTCGTCAAACACCTGGAAAAGGAATACGAAGAACGCGCGGTGCTCGTCATGGCCGATGGCGCCGACTCC
GCGACCAGCGATCTGGCCGAGCGCAACGATCTGGTCCGGCGCGTGCGTCTAGGCGTGCTGCAACACCAGCGGCAGGCCGT
CACCACGTTGCGCAACCAAAACCTCATCGACGACATCGTGCTGCGCGAGCTGCAGGCGGCGATGGATCTAGAGGAAGTGC
AACTCTTGGACCCCGCCGACGCCGAGTGA

Upstream 100 bases:

>100_bases
CCTCGATGACATTGTGCCGTGCGCCACGTTGTCAGCGGACTGAGTCGACCCAACATCTCGCGGTGTTCGCCAGGGTGCCG
AAACAGGTCAACGCGGCGGT

Downstream 100 bases:

>100_bases
GCCGGCGCCGCCCGCTGATCGAACCAGCAACGGTTCAGGTTTTGGCCATTGCTTTCACAGACTCATTCAGCGTTTCATTG
CACTGGCCGCAGCGCGAGCA

Product: integral membrane transport protein yjcE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSLLGLIPRFGDVQIDGEVVLLLFLPAILYWES
MNTSFREIRWNLRVIVMFSIGLVIATAVAVSWTARALGMESHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLI
NDGTALVLFAVTVAVAEGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTPFAAFLLAQSL
KCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTG
VVIATRIAWVQATTVLGHTVDRVLKKPTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVI
LVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQAALDALPTVADELGVAPDLVKHLEKEYEERAVLVMADGADS
ATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE

Sequences:

>Translated_542_residues
MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSLLGLIPRFGDVQIDGEVVLLLFLPAILYWES
MNTSFREIRWNLRVIVMFSIGLVIATAVAVSWTARALGMESHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLI
NDGTALVLFAVTVAVAEGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTPFAAFLLAQSL
KCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTG
VVIATRIAWVQATTVLGHTVDRVLKKPTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVI
LVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQAALDALPTVADELGVAPDLVKHLEKEYEERAVLVMADGADS
ATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE
>Mature_542_residues
MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSLLGLIPRFGDVQIDGEVVLLLFLPAILYWES
MNTSFREIRWNLRVIVMFSIGLVIATAVAVSWTARALGMESHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLI
NDGTALVLFAVTVAVAEGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTPFAAFLLAQSL
KCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTG
VVIATRIAWVQATTVLGHTVDRVLKKPTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVI
LVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQAALDALPTVADELGVAPDLVKHLEKEYEERAVLVMADGADS
ATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Homologues:

Organism=Escherichia coli, GI1790501, Length=563, Percent_Identity=28.9520426287744, Blast_Score=175, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6320663, Length=382, Percent_Identity=22.7748691099476, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221473212, Length=412, Percent_Identity=23.0582524271845, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281364513, Length=389, Percent_Identity=23.1362467866324, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221473222, Length=389, Percent_Identity=23.1362467866324, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221473215, Length=389, Percent_Identity=23.1362467866324, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2287_MYCTU (P65526)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   C70732
- RefSeq:   NP_216803.1
- RefSeq:   NP_336815.1
- ProteinModelPortal:   P65526
- EnsemblBacteria:   EBMYCT00000001459
- EnsemblBacteria:   EBMYCT00000072006
- GeneID:   887570
- GeneID:   924078
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2345
- KEGG:   mtu:Rv2287
- TIGR:   MT2345
- TubercuList:   Rv2287
- GeneTree:   EBGT00050000016154
- HOGENOM:   HBG648988
- OMA:   PAVVRWA
- ProtClustDB:   CLSK791753
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705
- PANTHER:   PTHR10110
- PANTHER:   PTHR10110:SF1
- TIGRFAMs:   TIGR00831

Pfam domain/function: PF00999 Na_H_Exchanger

EC number: NA

Molecular weight: Translated: 57492; Mature: 57492

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1af0b874)-; HASH(0x1bde0680)-; HASH(0x1b8dc2c8)-; HASH(0x1b9508e8)-; HASH(0x1ba63644)-; HASH(0x1b9a3dfc)-; HASH(0x1a589a30)-; HASH(0x17922d84)-; HASH(0x1b8ca99c)-; HASH(0x196b2824)-; HASH(0x1bbe08d4)-; HASH(0x1a978b78)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSLLGLIPRFGDV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCHHHHHCCCCCCE
QIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFSIGLVIATAVAVSWTARALGME
EECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLINDGTALVLFAVTVAVAEGAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCC
GIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTPFAAFLLAQSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
KCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWVFVGVQIPGAIDH
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHH
IAGEDGGLPRATVLALAVTGVVIATRIAWVQATTVLGHTVDRVLKKPTRHVGFRQRCVTS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
WAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWARM
HHHHHHHHHHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
PEDVAHANELQLARTRSAQAALDALPTVADELGVAPDLVKHLEKEYEERAVLVMADGADS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCCCC
ATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCC
AE
CH
>Mature Secondary Structure
MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSLLGLIPRFGDV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCHHHHHCCCCCCE
QIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFSIGLVIATAVAVSWTARALGME
EECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLINDGTALVLFAVTVAVAEGAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCC
GIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTPFAAFLLAQSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
KCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWVFVGVQIPGAIDH
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHH
IAGEDGGLPRATVLALAVTGVVIATRIAWVQATTVLGHTVDRVLKKPTRHVGFRQRCVTS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
WAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWARM
HHHHHHHHHHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
PEDVAHANELQLARTRSAQAALDALPTVADELGVAPDLVKHLEKEYEERAVLVMADGADS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEECCCCC
ATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCC
AE
CH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036