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The map label for this gene is yuaR [C]

Identifier: 148823431

GI number: 148823431

Start: 2505983

End: 2507545

Strand: Reverse

Name: yuaR [C]

Synonym: TBFG_12252

Alternate gene names: 148823431

Gene position: 2507545-2505983 (Counterclockwise)

Preceding gene: 148823432

Following gene: 148823430

Centisome position: 56.67

GC content: 67.11

Gene sequence:

>1563_bases
ATGGCGGCCATGTGGCGCCGCAGACCGTTGAGCTCGGCGCTGCTGTCCTTCGGGTTGCTGCTCGGCGGACTGCCCCTAGC
AGCGCCCCCGTTGGCCGGCGCGACTGAAGAACCCGGCGCCGGCCAAACCCCGGGTGCGCCGGTCGTGGCGCCGCAACAGA
GTTGGAACAGCTGCCGCGAGTTCATCGCCGACACCAGCGAAATTCGCACTGCACGCTGCGCGACGGTGTCCGTCCCCGTC
GACTACGACCAACCCGGTGGGACACAAGCGAAGTTGGCGGTGATCCGCGTCCCCGCGACGGGACAGCGATTCGGAGCACT
GCTGGTCAATCCTGGGGGACCCGGGGCGTCGGCGGTCGACATGGTCGCCGCTATGGCACCCGCGATCGCCGACACCGACA
TTCTCCGCCACTTCGACCTGGTGGGCTTCGACCCGAGAGGGGTCGGCCACTCGACCCCTGCGTTGCGGTGTCGCACCGAC
GCCGAGTTCGACGCGTACCGGCGCGATCCGATGGCCGACTACAGTCCGGCCGGTGTCACCCACGTCGAACAGGTCTACCG
GCAGTTGGCCCAGGACTGTGTTGACCGGATGGGCTTCAGCTTCTTGGCCAATATCGGTACCGCGTCCGTCGCACGGGACA
TGGACATGGTTCGCCAAGCGTTAGGTGACGATCAGATCAACTACCTCGGATACAGCTACGGCACCGAGTTGGGCACCGCT
TACCTGGAACGGTTCGGTACTCATGTGCGGGCGATGGTCCTCGACGGCGCTATCGATCCAGCCGTTAGCCCAATCGAGGA
AAGCATCAGCCAAATGGCGGGATTTCAGACCGCTTTCAATGACTACGCCGCCGACTGCGCCCGCTCGCCGGCCTGCCCTC
TGGGCACCGACTCGGCCCAGTGGGTCAACCGCTACCACGCCCTGGTTGACCCGCTGGTGCAGAAGCCGGGTAAGACGTCG
GATCCACGTGGCCTGAGCTACGCCGACGCGACGACGGGCACCATCAACGCGCTGTACAGCCCTCAGCGCTGGAAGTACCT
GACCAGTGGTCTGCTGGGGCTGCAGCGCGGCAGCGACGCCGGCGACTTGCTGGTGCTTGCCGACGACTATGACGGCCGGG
ATGCAGACGGGCACTACAGCAACGACCAGGACGCGTTCAACGCGGTCCGGTGCGTCGATGCGCCCACACCGGCCGATCCA
GCGGCCTGGGTGGCCGCCGACCAACGGATCCGTCAGGTCGCCCCGTTCCTTAGCTACGGGCAGTTCACCGGATCCGCCCC
CCGCGATCTGTGCGCGCTGTGGCCGGTGCCGGCAACGTCGACGCCGCACCCCGCGGCGCCGGCCGGGGCTGGCAAGGTCG
TCGTGGTGTCCACCACCCACGACCCGGCCACTCCGTATCAGTCCGGGGTAGACCTGGCCCGCCAGCTGGGCGCACCGCTG
ATCACCTTCGACGGCACCCAACACACTGCGGTGTTCGATGGCAACCAGTGTGTGGACTCTGCGGTGATGCACTATTTTCT
CGACGGGACCTTGCCGCCGACGAGTCTGCGGTGCGCGCCCTGA

Upstream 100 bases:

>100_bases
ATCGGCGGCACCACGCCGCCCAGCGGCGCCAAGTGCTAGCGGGGCGAAGAAACGAAGGTGTGATCATTTCGCGCCGTCAC
AGGTATTCGCCGGTGAGACG

Downstream 100 bases:

>100_bases
ACTCACCGCGCACTCCCCTTGCGGGCCGCCCCGCAACGCTTCTGGCCGGGCATCGGTAACACGGTTTTAACAGACAGTGC
ATACTGTTCGAGGTATGGAC

Product: exported protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPV
DYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTD
AEFDAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTA
YLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTS
DPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADP
AAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPL
ITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP

Sequences:

>Translated_520_residues
MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPV
DYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTD
AEFDAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTA
YLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTS
DPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADP
AAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPL
ITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
>Mature_519_residues
AAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVD
YDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDA
EFDAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTAY
LERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTSD
PRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPA
AWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPLI
TFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2223_MYCTU (P65821)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   C70776
- RefSeq:   NP_216739.1
- RefSeq:   NP_336752.1
- ProteinModelPortal:   P65821
- EnsemblBacteria:   EBMYCT00000001723
- EnsemblBacteria:   EBMYCT00000072524
- GeneID:   888093
- GeneID:   924144
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2281
- KEGG:   mtu:Rv2223c
- TIGR:   MT2281
- TubercuList:   Rv2223c
- GeneTree:   EBGT00050000016435
- HOGENOM:   HBG732622
- OMA:   AFNSIRC
- ProtClustDB:   CLSK2748637
- InterPro:   IPR000073
- InterPro:   IPR013595

Pfam domain/function: PF00561 Abhydrolase_1; PF08386 Abhydrolase_4

EC number: NA

Molecular weight: Translated: 55078; Mature: 54947

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: ACT_SITE 232-232 ACT_SITE 461-461 ACT_SITE 488-488

Signals:

None

Transmembrane regions:

HASH(0x1b28e3b0)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCRE
CCCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHH
FIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVD
HHHCHHHHHHEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCHHHHH
MVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCHH
HVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHH
YLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQ
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
WVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCC
GDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVAADQRIRQVAPFLSYG
CCEEEEECCCCCCCCCCCCCCCHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
QFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPL
CCCCCCCHHHHEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCE
ITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
EEECCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure 
AAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTPGAPVVAPQQSWNSCRE
CCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHH
FIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQRFGALLVNPGGPGASAVD
HHHCHHHHHHEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCHHHHH
MVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTDAEFDAYRRDPMADYSPAGVT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCHH
HVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVRQALGDDQINYLGYSYGTELGTA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHH
YLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQTAFNDYAADCARSPACPLGTDSAQ
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
WVNRYHALVDPLVQKPGKTSDPRGLSYADATTGTINALYSPQRWKYLTSGLLGLQRGSDA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCC
GDLLVLADDYDGRDADGHYSNDQDAFNAVRCVDAPTPADPAAWVAADQRIRQVAPFLSYG
CCEEEEECCCCCCCCCCCCCCCHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
QFTGSAPRDLCALWPVPATSTPHPAAPAGAGKVVVVSTTHDPATPYQSGVDLARQLGAPL
CCCCCCCHHHHEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCE
ITFDGTQHTAVFDGNQCVDSAVMHYFLDGTLPPTSLRCAP
EEECCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036