Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 148823420

GI number: 148823420

Start: 2490484

End: 2492031

Strand: Direct

Name: pepA [H]

Synonym: TBFG_12241

Alternate gene names: 148823420

Gene position: 2490484-2492031 (Clockwise)

Preceding gene: 148823419

Following gene: 148823422

Centisome position: 56.29

GC content: 67.38

Gene sequence:

>1548_bases
GTGACCACCGAACCGGGTTACCTATCCCCCTCCGTCGCCGTCGCGACCTCGATGCCGAAACGTGGTGTCGGCGCTGCGGT
GTTGATCGTGCCGGTCGTCTCGACCGGCGAAGAGGATCGGCCCGGCGCGGTCGTTGCCTCGGCCGAGCCCTTCCTGCGCG
CCGACACGGTTGCCGAAATCGAGGCGGGCCTGCGAGCGCTGGACGCCACCGGCGCCAGTGACCAGGTGCACCGGCTGGCG
GTGCCGTCGTTGCCGGTGGGCAGCGTCCTGACGGTCGGCCTGGGCAAACCGCGGCGCGAATGGCCGGCCGATACCATCCG
CTGCGCCGCCGGCGTGGCCGCGCGTGCGCTCAACAGTTCGGAGGCAGTGATCACCACGCTAGCCGAATTACCTGGCGACG
GCATCTGCTCGGCCACCGTCGAGGGGCTGATCCTGGGCAGCTACCGATTCAGCGCCTTCCGCAGCGACAAGACCGCGCCC
AAAGACGCCGGACTCCGCAAAATCACCGTGCTCTGCTGTGCAAAGGACGCCAAGAAGCGCGCGTTGCACGGTGCGGCCGT
CGCGACCGCGGTGGCCACCGCCCGGGACTTGGTCAACACTCCCCCAAGCCACCTGTTTCCCGCCGAGTTCGCTAAGCGCG
CAAAGACTTTGAGCGAATCTGTCGGCCTCGACGTGGAAGTTATCGACGAAAAGGCGCTGAAGAAGGCCGGCTATGGCGGG
GTGATTGGTGTCGGCCAGGGCTCGTCGCGGCCGCCGCGACTGGTGCGGTTGATTCATCGGGGATCGCGGCTGGCCAAGAA
CCCCCAAAAGGCCAAGAAGGTGGCCTTGGTTGGCAAGGGGATCACCTTCGATACCGGCGGCATCTCGATCAAGCCGGCAG
CGTCGATGCACCACATGACCTCGGACATGGGCGGAGCGGCCGCGGTGATCGCCACTGTCACGCTGGCTGCCCGGCTGCGA
CTGCCGATTGACGTGATCGCCACGGTGCCGATGGCCGAGAACATGCCGTCGGCGACGGCGCAGCGCCCGGGCGACGTGCT
GACCCAATACGGTGGGACCACCGTCGAGGTGCTCAACACCGACGCGGAGGGCCGGTTGATCCTGGCCGACGCCATCGTCC
GGGCATGTGAGGACAAGCCGGACTATCTGATCGAGACATCCACGTTGACCGGTGCGCAAACGGTGGCGCTGGGGACGCGC
ATACCGGGTGTGATGGGCAGCGACGAGTTCCGCGACCGGGTCGCCGCGATCTCGCAGCGGGTGGGCGAGAACGGCTGGCC
GATGCCGCTGCCCGATGACCTCAAGGATGACTTGAAATCCACGGTGGCCGACCTGGCCAATGTGAGTGGCCAGCGTTTCG
CAGGCATGCTGGTGGCCGGGGTTTTCCTGCGTGAGTTCGTCGCCGAATCGGTGGATTGGGCGCACATCGACGTGGCCGGC
CCGGCCTACAACACCGGCAGCGCCTGGGGTTACACGCCCAAGGGCGCCACCGGTGTGCCCACCCGCACCATGTTCGCGGT
GCTCGAGGACATCGCGAAGAACGGGTAG

Upstream 100 bases:

>100_bases
GGTTTGACGCCCCGGTGATGGCCTTCGAACTGCACGACAACCCTCGTGCGAGGGATGCTGACACGCCAAGCCCCGCCGCC
AGTGATTAGGGTGGTTGCCC

Downstream 100 bases:

>100_bases
GCGGCCGCCCGGACCCAAAGCACTTCACGAGTAGCGGTTAGATCACCCGCAGCCGCGCGGTACTGCGCAGCGCCTGCGGC
AGCACCCGGGAGATGCCGTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLA
VPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAP
KDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGG
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLR
LPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTR
IPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG

Sequences:

>Translated_515_residues
MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLA
VPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAP
KDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGG
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLR
LPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTR
IPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
>Mature_514_residues
TTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAV
PSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPK
DAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGGV
IGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRL
PIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRI
PGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAGP
AYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=433, Percent_Identity=35.3348729792148, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI47155554, Length=338, Percent_Identity=32.2485207100592, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1790710, Length=456, Percent_Identity=37.0614035087719, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082123, Length=390, Percent_Identity=35.1282051282051, Blast_Score=176, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=347, Percent_Identity=32.8530259365994, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24661038, Length=334, Percent_Identity=31.1377245508982, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21355725, Length=453, Percent_Identity=29.1390728476821, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI221379063, Length=306, Percent_Identity=34.3137254901961, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI221379062, Length=306, Percent_Identity=34.3137254901961, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21357381, Length=306, Percent_Identity=34.3137254901961, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24662227, Length=418, Percent_Identity=27.9904306220096, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI20129969, Length=421, Percent_Identity=28.978622327791, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21355645, Length=423, Percent_Identity=28.6052009456265, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24662223, Length=423, Percent_Identity=28.6052009456265, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI161077148, Length=427, Percent_Identity=28.1030444964871, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI20130057, Length=427, Percent_Identity=28.1030444964871, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI20129963, Length=422, Percent_Identity=28.1990521327014, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI19922386, Length=438, Percent_Identity=26.7123287671233, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646701, Length=216, Percent_Identity=32.8703703703704, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=216, Percent_Identity=32.8703703703704, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=216, Percent_Identity=32.8703703703704, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53482; Mature: 53351

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEI
CCCCCCCCCCCHHHECCCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHH
EAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSS
HHHHHHHCCCCCCCCHHEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
EAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKR
HHHHHHHHHCCCCCCHHHHHHHEEEECCHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHH
ALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCC
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMT
EEEECCCCCCCHHHHHHHHHCHHHHCCHHHHHEEEEEECCEEECCCCEEECCCHHHHHHH
SDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNT
HCCCCHHHHHHHHHHHHHHCCCHHHEEECCCCCCCCCCHHCCCHHHHHHCCCCEEEEEEC
DAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQR
CCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
VGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEI
CCCCCCCCCCHHHECCCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHH
EAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSS
HHHHHHHCCCCCCCCHHEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
EAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKR
HHHHHHHHHCCCCCCHHHHHHHEEEECCHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHH
ALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGG
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCCC
VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMT
EEEECCCCCCCHHHHHHHHHCHHHHCCHHHHHEEEEEECCEEECCCCEEECCCHHHHHHH
SDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNT
HCCCCHHHHHHHHHHHHHHCCCHHHEEECCCCCCCCCCHHCCCHHHHHHCCCCEEEEEEC
DAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQR
CCCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
VGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]