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The map label for this gene is argE [C]

Identifier: 148823350

GI number: 148823350

Start: 2413937

End: 2415289

Strand: Reverse

Name: argE [C]

Synonym: TBFG_12171

Alternate gene names: 148823350

Gene position: 2415289-2413937 (Counterclockwise)

Preceding gene: 148823351

Following gene: 148823349

Centisome position: 54.59

GC content: 65.04

Gene sequence:

>1353_bases
GTGACTGTGACAGATGAGACCGGGGCTTCAAGCGACCACAGCGATGATGTCGCCCAGGTCGTCAGCAGGCTAATCCGGTT
CGATACCACCAACAGTGGCGAACCCGGGACCACCAAGGGTGAGGCCGAGTGCGCACGCTGGGTCGCCGAGCAGCTCGCCG
AAGTCGGCTACCAACCTGAATACGTTGAATCCGGTGCGCCCGGCCGCGGCAACGTGTTCGCCCGGCTGGCGGGCGCCGAT
AGTTCTCGCGGCGCGCTGCTGATCCACGGGCATCTCGATGTGGTGCCGGCTGAACCGGCCGAATGGAGTGTGCACCCGTT
TTCCGGCGCCATCGAAGACGGCTACGTCTGGGGTCGTGGCGCGGTCGACATGAAGGACATGGTGGGCATGATGATTGTGG
TTGCCCGCCACCTTCGTCAGGCCGCTATCGTGCCGCCACGGGATCTGGTGTTCGCGTTCGTTGCCGACGAGGAGCACGGC
GGCAAGTACGGGTCGCACTGGCTGGTCGACAATAGGCCCGATCTGTTCGACGGCATCACCGAGGCAATCGGTGAAGTCGG
CGGTTTCTCGCTAACCGTGCCCCGGCACGATGGTGGCGAACGTCGCCTGTACCTGATTGAAACCGCCGAGAAGGGCATCC
AGTGGATGCGGCTGACGGCACGCGGCCGGGCTGGGCACGGCTCGATGGTGCACGACCAGAACGCGGTCACCGCCGTTTGT
GAGGCGGTCGCTCGCCTAGGGCGCCACCAGTTTCCGCTGGTCTGCACTGACACCGTCGCCCAGTTCTTGGCCGTAGTCGG
AGAGGAGACCGGACTGGCCTTCGACCTTGACTCGCCGGACCTGGCCGGGACGATCGACAAGCTTGGCCCGATGGCCCGCA
TGTTGAAGGCAGTGCTACATGACACCGCGAACCCTACGATGCTCAAGGCCGGATACAAGGCCAACGTCGTCCCGGCGACC
GCGGAGGCAGTTGTGGACTGCCGCGTGCTTCCGGGTCGCCGGGCGGCGTTCGAGGCCGAAGTCGACGCGCTGATCGGACC
CGACGTGACCCGGGAGTGGGTCAGCGATCTGCCATCATATGAGACCACCTTCGACGGTGATCTGGTCGCCGCCATGAACG
CCGCGGTGTTGGCGGTCGACCCAGACGGTCGCACGGTGCCGTACATGCTGTCCGGTGGAACGGACGCGAAGGCGTTCGCG
CGCTTGGGTATTCGGTGCTTTGGCTTCAGCCCGCTGCGCTTGCCGCCGGACTTGGATTTCACCTCGTTGTTCCACGGCGT
CGACGAGCGGGTACCCATCGATGGGTTGCGGTTCGGCACCGAGGTGCTAACGCACTTGCTGACACACTGCTAG

Upstream 100 bases:

>100_bases
GCCAGGCAATCAGCCCACGTAAGCAAATCCAGCTCGGCGACGACGCGGGCCCGGCGCGCCAGGGGCGATCGGCTCGCCAG
GGTTACGAGTGGTAGGAAAG

Downstream 100 bases:

>100_bases
TCGAAAACGAGGCTAGTCGCAACGTCGATCACACGAGAGGACTGACCATGACAACTTCACCCGACCCGTATGCCGCGCTG
CCCAAGCTGCCGTCCTTCAG

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTVTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGAD
SSRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHG
GKYGSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVC
EAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPAT
AEAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFA
RLGIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC

Sequences:

>Translated_450_residues
MTVTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGAD
SSRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHG
GKYGSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVC
EAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPAT
AEAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFA
RLGIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC
>Mature_449_residues
TVTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADS
SRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGG
KYGSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVCE
AVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATA
EAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFAR
LGIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=440, Percent_Identity=26.3636363636364, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501901, Length=389, Percent_Identity=26.7352185089974, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24649206, Length=416, Percent_Identity=25.2403846153846, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24649210, Length=414, Percent_Identity=24.8792270531401, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649202, Length=413, Percent_Identity=24.9394673123487, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24649204, Length=413, Percent_Identity=24.9394673123487, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24649212, Length=425, Percent_Identity=25.1764705882353, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24649208, Length=389, Percent_Identity=25.1928020565553, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356353, Length=387, Percent_Identity=24.5478036175711, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 48343; Mature: 48212

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPE
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
YVESGAPGRGNVFARLAGADSSRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRG
HHCCCCCCCCCEEEEEECCCCCCCEEEEECCEEEECCCCCCCEECCCCCCCCCCEEECCC
AVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGKYGSHWLVDNRPDLFDGIT
CCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCCEEEECCCCHHHHHHH
EAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVC
HHHHHCCCEEEEECCCCCCCEEEEEEECHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
EAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLH
HHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
DTANPTMLKAGYKANVVPATAEAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSY
CCCCCCEEECCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCC
ETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARLGIRCFGFSPLRLPPDLDF
CCCCCCCHHEECCCEEEEECCCCCEECEEEECCCCHHHHHHHCEEEECCCCCCCCCCCCH
TSLFHGVDERVPIDGLRFGTEVLTHLLTHC
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
YVESGAPGRGNVFARLAGADSSRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRG
HHCCCCCCCCCEEEEEECCCCCCCEEEEECCEEEECCCCCCCEECCCCCCCCCCEEECCC
AVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGKYGSHWLVDNRPDLFDGIT
CCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCCEEEECCCCHHHHHHH
EAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVC
HHHHHCCCEEEEECCCCCCCEEEEEEECHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
EAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLH
HHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
DTANPTMLKAGYKANVVPATAEAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSY
CCCCCCEEECCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCC
ETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARLGIRCFGFSPLRLPPDLDF
CCCCCCCHHEECCCEEEEECCCCCEECEEEECCCCHHHHHHHCEEEECCCCCCCCCCCCH
TSLFHGVDERVPIDGLRFGTEVLTHLLTHC
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]