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The map label for this gene is pyrD

Identifier: 148823348

GI number: 148823348

Start: 2412281

End: 2413354

Strand: Direct

Name: pyrD

Synonym: TBFG_12169

Alternate gene names: 148823348

Gene position: 2412281-2413354 (Clockwise)

Preceding gene: 148823347

Following gene: 148823352

Centisome position: 54.52

GC content: 68.72

Gene sequence:

>1074_bases
ATGTATCCCCTGGTGCGTCGGCTGTTGTTCCTGATCCCACCCGAGCACGCGCACAAGTTGGTTTTCGCCGTGCTGCGCGG
CGTGGCCGCCGTGGCGCCAGTGCGCCGGCTCTTGCGCCGACTGCTGGGCCCGACGGATCCGGTGCTGGCCAGCACGGTGT
TCGGGGTGCGCTTCCCGGCACCGCTCGGGCTGGCCGCGGGGTTCGACAAGGACGGCACCGCACTATCCAGTTGGGGTGCG
ATGGGGTTCGGCTACGCCGAGATCGGCACCGTCACCGCTCATCCGCAGCCCGGCAACCCGGCCCCCCGCCTGTTCCGGCT
GGCCGACGACCGCGCCCTGCTGAACCGGATGGGGTTCAACAATCACGGTGCCCGGGCACTGGCGATCCGACTCGCGCGGC
ACCGACCCGAGATCCCGATCGGGGTGAATATCGGCAAGACCAAGAAAACGCCGGCCGGCGACGCGGTCAACGACTACCGG
GCCAGCGCCCGGATGGTCGGCCCGCTGGCGTCGTATCTGGTGGTCAACGTCAGCTCTCCGAACACACCGGGGTTACGCGA
TCTGCAGGCGGTCGAATCGCTGCGGCCCATCCTGTCTGCCGTCCGCGCCGAGACTTCGACGCCGGTGCTGGTGAAGATCG
CGCCGGACTTGTCCGATTCCGACCTCGACGACATCGCGGACCTGGCCGTCGAGCTAGACCTGGCCGGCATCGTGGCAACC
AACACCACGGTGTCACGCGACGGCCTGACCACACCGGGGGTCGACCGGTTGGGTCCCGGCGGCATCTCGGGGCCACCGCT
GGCTCAGCGCGCGGTCCAGGTGCTGCGTCGGCTCTATGACCGGGTCGGTGATCGATTGGCGCTGATCAGCGTGGGCGGGA
TCGAGACGGCCGACGACGCGTGGGAGCGCATCACAGCGGGCGCATCGCTGCTACAGGGCTATACCGGCTTCATCTACGGC
GGGGAACGGTGGGCCAAGGACATCCATGAAGGCATTGCCCGCAGGCTGCATGACGGCGGGTTCGGCTCGCTGCACGAAGC
GGTCGGCTCGGCAAGACGTCGGCAACCCAGCTAA

Upstream 100 bases:

>100_bases
AGAAATCTCGCTGGGCAGACGCAGAGGCGAACCGCCGGCCAGACCAGCCGCAGCTGTGGCTCTGAAGGCCGGGGCCAGCC
CGCGCGCAGACCGCTATCGG

Downstream 100 bases:

>100_bases
AGCGCTAACGCTGCTCGTAGGTGCCGAAGATGACCGCTCGTGCAATCGCGTGCTGGAACAGGTTGAATCCCAGATATGCA
GGACTCGCGTCCTCGGGGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYG
GERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS

Sequences:

>Translated_357_residues
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYG
GERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
>Mature_357_residues
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYG
GERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=360, Percent_Identity=43.0555555555556, Blast_Score=248, Evalue=8e-66,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=43.620178041543, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI87082059, Length=335, Percent_Identity=27.4626865671642, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=39.8773006134969, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281361352, Length=359, Percent_Identity=37.3259052924791, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI17137316, Length=359, Percent_Identity=37.3259052924791, Blast_Score=231, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_MYCBO (P65909)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855812.1
- ProteinModelPortal:   P65909
- SMR:   P65909
- EnsemblBacteria:   EBMYCT00000016211
- GeneID:   1091228
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2163
- GeneTree:   EBGT00050000017343
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   MBOV233413:MB2163-MONOMER
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37999; Mature: 37999

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPA
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN
CCCHHCCCCCCCCHHHHCCCCCCCHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCC
NTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEE
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDA
CCEECCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHH
WERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
HHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPA
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN
CCCHHCCCCCCCCHHHHCCCCCCCHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCC
NTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEE
NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDA
CCEECCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHH
WERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS
HHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972