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The map label for this gene is fdh [H]

Identifier: 148823107

GI number: 148823107

Start: 2150737

End: 2151891

Strand: Direct

Name: fdh [H]

Synonym: TBFG_11924

Alternate gene names: 148823107

Gene position: 2150737-2151891 (Clockwise)

Preceding gene: 148823106

Following gene: 148823110

Centisome position: 48.61

GC content: 66.06

Gene sequence:

>1155_bases
ATGCGTGCGGTAGTCATCGACGGGGCCGGCAGCGTCAGAGTCAACACCCAGCCCGACCCGGCACTGCCCGGGCCTGACGG
AGTGGTTGTCGCCGTGACCGCCGCCGGCATCTGCGGATCCGATCTGCATTTCTACGAAGGCGAATATCCGTTCACCGAGC
CGGTGGCCCTCGGTCACGAGGCGGTAGGCACCATCGTCGAGGCCGGGCCACAGGTGCGCACCGTCGGAGTTGGCGACCTG
GTCATGGTGTCTTCAGTGGCCGGCTGCGGCGTCTGCCCGGGATGCGAAACCCATGATCCAGTCATGTGCTTCTCCGGCCC
GATGATCTTCGGCGCCGGCGTGCTTGGCGGCGCACAGGCCGATCTGCTGGCGGTGCCGGCCGCCGATTTCCAGGTGCTCA
AGATCCCCGAAGGTATCACCACCGAGCAGGCACTGCTGCTCACGGACAACCTCGCCACCGGTTGGGCGGCAGCCCAACGA
GCCGATATTTCATTCGGCTCCGCCGTGGCGGTCATCGGCCTGGGAGCCGTCGGCCTCTGCGCGCTGCGCAGCGCCTTCAT
ACACGGTGCCGCAACGGTTTTCGCTGTCGACCGAGTAAAGGGACGCTTGCAACGCGCGGCCACCTGGGGTGCTACGCCGA
TACCGTCACCGGCGGCCGAGACGATTCTGGCCGCGACGCGGGGTCGCGGCGCAGACTCGGTGATTGACGCCGTCGGCACC
GACGCCTCGATGAGCGACGCGCTCAATGCGGTGCGCCCTGGCGGCACCGTCTCGGTTGTCGGCGTGCACGATCTTCAGCC
GTTTCCCCTGCCCGCACTGACGTGCCTGTTGCGAAGCATCACGCTGCGAATGACCATGGCACCGGTACAACGAACCTGGC
CGGAACTGATCCCGTTGCTGCAGTCGGGCCGACTCGATGTCGATGGCATCTTCACTACCACCCTGCCGTTGGACGAAGCG
GCCAAGGGCTATGCAACCGCGAGGGCGCGCTCGGGTGAGGAGCTAAGGTTCTGCTTACGCCCTGACAGCCGTGATGTACT
GGGAGCGCATGAAACTGTCGATCTTTACGTCCACGTCCGGCGGTGTCAGTCCGTAGCCGACCTGCAGCTCGAGGGTGCTG
CGGACGGGGTCGACGGCCCATCCATGCTCAACTAG

Upstream 100 bases:

>100_bases
GCCGTTCACTACGTTCAAACGCCCGAGACCGGTGCCAGGCAGGTACGCGAACCTCATGGGTCTCAATTCGTTCTGCCACA
AAGAAAGTGAGTAAGCCAGC

Downstream 100 bases:

>100_bases
CCACTCCACGGGATCGGTCTTGTCGTCGTAGGTGAGCGCGGAGAAATTCACGTCACCAGACATATTGACCCCCGGGTGTG
CGGTTTCCAGCGCGGCGAGC

Product: dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDL
VMVSSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR
ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAAETILAATRGRGADSVIDAVGT
DASMSDALNAVRPGGTVSVVGVHDLQPFPLPALTCLLRSITLRMTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEA
AKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN

Sequences:

>Translated_384_residues
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDL
VMVSSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR
ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAAETILAATRGRGADSVIDAVGT
DASMSDALNAVRPGGTVSVVGVHDLQPFPLPALTCLLRSITLRMTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEA
AKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN
>Mature_384_residues
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDL
VMVSSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR
ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAAETILAATRGRGADSVIDAVGT
DASMSDALNAVRPGGTVSVVGVHDLQPFPLPALTCLLRSITLRMTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEA
AKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=364, Percent_Identity=27.1978021978022, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=27.3239436619718, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI71743840, Length=357, Percent_Identity=27.4509803921569, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501929, Length=356, Percent_Identity=26.9662921348315, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501933, Length=342, Percent_Identity=27.7777777777778, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI34577061, Length=356, Percent_Identity=26.685393258427, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=340, Percent_Identity=24.7058823529412, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI71565154, Length=344, Percent_Identity=25.2906976744186, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI156523966, Length=348, Percent_Identity=26.4367816091954, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4501939, Length=331, Percent_Identity=26.8882175226586, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786825, Length=402, Percent_Identity=32.8358208955224, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=29.7297297297297, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI226510992, Length=318, Percent_Identity=30.5031446540881, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=28.0966767371601, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=275, Percent_Identity=28.7272727272727, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=27.0029673590504, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787863, Length=267, Percent_Identity=26.9662921348315, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788407, Length=304, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=292, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=26.9938650306748, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=25.6267409470752, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=342, Percent_Identity=26.9005847953216, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=25.4237288135593, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=311, Percent_Identity=24.4372990353698, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=24.8520710059172, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=347, Percent_Identity=24.4956772334294, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=342, Percent_Identity=24.2690058479532, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=292, Percent_Identity=24.3150684931507, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=356, Percent_Identity=28.9325842696629, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=356, Percent_Identity=28.9325842696629, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=27.5659824046921, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=346, Percent_Identity=28.0346820809249, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=382, Percent_Identity=23.8219895287958, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=265, Percent_Identity=27.5471698113208, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=291, Percent_Identity=25.7731958762887, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=268, Percent_Identity=25.7462686567164, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17137530, Length=352, Percent_Identity=30.3977272727273, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737897, Length=354, Percent_Identity=28.8135593220339, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI17737895, Length=359, Percent_Identity=25.6267409470752, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550770, Length=314, Percent_Identity=27.7070063694268, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551930, Length=314, Percent_Identity=27.7070063694268, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221457811, Length=314, Percent_Identity=27.7070063694268, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 39494; Mature: 39494

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHE
CEEEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCHHHCHH
AVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGAQA
HHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCC
DLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLC
CEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
ALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAAETILAATRGRGADSVIDAVGT
HHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCC
DASMSDALNAVRPGGTVSVVGVHDLQPFPLPALTCLLRSITLRMTMAPVQRTWPELIPLL
CCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVR
HCCCCCCCEEEEEECCHHHHHCCHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEH
RCQSVADLQLEGAADGVDGPSMLN
HHHHHHCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHE
CEEEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCHHHCHH
AVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGAQA
HHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCC
DLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLC
CEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
ALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPAAETILAATRGRGADSVIDAVGT
HHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCC
DASMSDALNAVRPGGTVSVVGVHDLQPFPLPALTCLLRSITLRMTMAPVQRTWPELIPLL
CCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVR
HCCCCCCCEEEEEECCHHHHHCCHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEH
RCQSVADLQLEGAADGVDGPSMLN
HHHHHHCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]