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The map label for this gene is bioD

Identifier: 148822793

GI number: 148822793

Start: 1782497

End: 1783177

Strand: Direct

Name: bioD

Synonym: TBFG_11602

Alternate gene names: 148822793

Gene position: 1782497-1783177 (Clockwise)

Preceding gene: 148822792

Following gene: 148822794

Centisome position: 40.29

GC content: 72.69

Gene sequence:

>681_bases
TTGACGATCCTGGTCGTCACCGGGACCGGCACGGGGGTCGGCAAGACGGTCGTCTGCGCGGCGCTGGCGTCGGCCGCACG
TCAGGCCGGCATCGACGTGGCGGTGTGCAAGCCCGTTCAGACCGGCACCGCCCGCGGTGACGACGACCTCGCCGAGGTCG
GCCGGTTGGCCGGGGTGACCCAGCTGGCCGGCTTGGCGCGATATCCGCAGCCGATGGCCCCGGCCGCCGCCGCCGAACAC
GCCGGGATGGCGTTGCCCGCCCGCGATCAGATCGTGCGGCTGATCGCAGACCTGGACCGTCCCGGGCGGTTGACCCTCGT
CGAGGGGGCGGGCGGGCTGCTGGTCGAACTCGCCGAGCCGGGCGTCACGCTGCGCGATGTCGCCGTCGACGTGGCCGCCG
CGGCTTTGGTGGTGGTCACCGCGGACCTGGGCACCCTCAACCACACCAAGTTGACGTTGGAAGCGCTTGCTGCACAACAG
GTTTCATGTGCAGGGCTGGTGATCGGCAGCTGGCCGGACCCGCCCGGGTTGGTGGCAGCCTCGAATCGGTCCGCGCTGGC
GCGCATTGCTACGGTGCGGGCCGCTCTGCCCGCCGGGGCCGCGTCGCTGGATGCCGGGGACTTCGCGGCGATGAGCGCGG
CGGCGTTCGACCGCAACTGGGTTGCCGGGCTGGTCGGCTGA

Upstream 100 bases:

>100_bases
GTACGTCGCGGCTGCGGCTGACCGCGCGCGCATCGCTGAACGCCGGCGAGCTCGAGCTGGCCCGGCGGGTGCTGACGGAT
GTTCTCGCCGTGGCGCGCCG

Downstream 100 bases:

>100_bases
TGGTGCATTCGATCGAGTTGGTCTTCGACAGCGATACCGAGGCGGCGATCCGGCGCATCTGGGCGGGGTTGGCCGCCGCC
GGCATACCCAGCCAGGCGCC

Product: dithiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEH
AGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQ
VSCAGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG

Sequences:

>Translated_226_residues
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEH
AGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQ
VSCAGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
>Mature_225_residues
TILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHA
GMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQV
SCAGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family

Homologues:

Organism=Escherichia coli, GI1786995, Length=198, Percent_Identity=31.3131313131313, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOD_MYCBO (O52587)

Other databases:

- EMBL:   AF041819
- EMBL:   BX248339
- RefSeq:   NP_855249.1
- ProteinModelPortal:   O52587
- SMR:   O52587
- EnsemblBacteria:   EBMYCT00000017086
- GeneID:   1092482
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1597
- GeneTree:   EBGT00050000017652
- HOGENOM:   HBG650065
- OMA:   VVIGSWP
- ProtClustDB:   PRK00090
- BioCyc:   MBOV233413:MB1597-MONOMER
- BRENDA:   6.3.3.3
- HAMAP:   MF_00336
- InterPro:   IPR004472
- PIRSF:   PIRSF006755
- TIGRFAMs:   TIGR00347

Pfam domain/function: NA

EC number: =6.3.3.3

Molecular weight: Translated: 22426; Mature: 22295

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVT
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEP
HHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCC
GVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAA
CCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEE
SNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure 
TILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVT
EEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEP
HHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCC
GVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAA
CCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEE
SNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972