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The map label for this gene is frdB

Identifier: 148822776

GI number: 148822776

Start: 1764076

End: 1764816

Strand: Direct

Name: frdB

Synonym: TBFG_11585

Alternate gene names: 148822776

Gene position: 1764076-1764816 (Clockwise)

Preceding gene: 148822775

Following gene: 148822777

Centisome position: 39.87

GC content: 63.43

Gene sequence:

>741_bases
ATGGATCGAATTGTCATGGAGGTCTCCCGGTATCGGCCCGAGATCGAATCGGCCCCGACATTTCAGGCCTACGAGGTTCC
CCTCACCCGCGAATGGGCGGTGTTGGACGGCCTGACCTACATCAAGGATCACCTCGACGGAACACTCTCCTTCCGCTGGT
CGTGCCGGATGGGTATCTGCGGCAGTAGTGGTATGACGATCAACGGCGACCCAAAGCTGGCGTGCGCGACATTCCTTGCC
GATTACCTACCCGGGCCGGTGCGGGTGGAGCCGATGCGAAACTTCCCGGTGATCCGCGATCTCGTTGTCGACATCAGTGA
CTTCATGGCCAAGCTGCCCAGTGTGAAGCCGTGGCTCGTCCGGCATGATGAACCGCCCGTCGAAGACGGCGAATACCGGC
AGACCCCGGCCGAACTCGATGCATTCAAGCAGTTCAGCATGTGTATCAACTGCATGTTGTGCTACTCGGCGTGCCCGGTG
TACGCGCTGGACCCCGACTTCCTCGGTCCGGCGGCGATCGCGCTGGGGCAGCGGTACAACCTGGACTCGCGCGACCAAGG
TGCGGCGGATCGCAGGGATGTCCTGGCCGCGGCCGACGGCGCTTGGGCGTGCACCCTGGTGGGCGAATGTTCGACGGCTT
GTCCGAAAGGCGTCGATCCTGCCGGCGCGATCCAGCGCTACAAGCTGACCGCGGCCACGCACGCGCTGAAGAAGTTGCTG
TTCCCTTGGGGGGGCGGATGA

Upstream 100 bases:

>100_bases
TGGTTCATAGAGAAAGCGACGGAACGCTGCGGGTCGGCTACCTTCCGGTCACTATCACTCGCTGGCCACCGGGCGAACGC
GTGTATGGGAGGTAAGGATG

Downstream 100 bases:

>100_bases
GCGCCTATCGCCAGCCGGTCGAAAGATACTGGTGGGCGAGGCGGCGTTCTTACCTGCGATTCATGCTTCGCGAAATCAGT
TGCATCTTCGTGGCCTGGTT

Product: fumarate reductase iron-sulfur subunit frdB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLA
DYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPV
YALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKLL
FPWGGG

Sequences:

>Translated_246_residues
MDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLA
DYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPV
YALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKLL
FPWGGG
>Mature_246_residues
MDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLA
DYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPV
YALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKLL
FPWGGG

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain

Homologues:

Organism=Homo sapiens, GI115387094, Length=222, Percent_Identity=37.8378378378378, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1790596, Length=242, Percent_Identity=50, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=37.5, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17533915, Length=231, Percent_Identity=35.0649350649351, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=34.9137931034483, Blast_Score=136, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17137106, Length=228, Percent_Identity=35.9649122807018, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24643156, Length=227, Percent_Identity=36.5638766519824, Blast_Score=140, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRDB_MYCTU (Q10761)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   F70762
- RefSeq:   NP_216069.1
- RefSeq:   NP_336057.1
- ProteinModelPortal:   Q10761
- SMR:   Q10761
- EnsemblBacteria:   EBMYCT00000000779
- EnsemblBacteria:   EBMYCT00000069542
- GeneID:   886378
- GeneID:   924333
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1604
- KEGG:   mtu:Rv1553
- TIGR:   MT1604
- TubercuList:   Rv1553
- GeneTree:   EBGT00050000016375
- HOGENOM:   HBG616382
- OMA:   RVPKLAC
- ProtClustDB:   CLSK791244
- BRENDA:   1.3.99.1
- GO:   GO:0006810
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489
- Gene3D:   G3DSA:3.10.20.30
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR00384

Pfam domain/function: SSF54292 Ferredoxin; SSF46548 Helical_ferredxn

EC number: =1.3.99.1

Molecular weight: Translated: 27103; Mature: 27103

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGIC
CCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEE
GSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLV
CCCCCEECCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEE
RHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYALDPDFLGPAAIALGQRYN
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCC
LDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKLL
CCCCCCCCCHHHHHEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FPWGGG
CCCCCC
>Mature Secondary Structure
MDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGIC
CCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEE
GSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLV
CCCCCEECCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEE
RHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYALDPDFLGPAAIALGQRYN
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCC
LDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKLL
CCCCCCCCCHHHHHEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FPWGGG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036