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The map label for this gene is mutA [H]

Identifier: 148822713

GI number: 148822713

Start: 1686770

End: 1688641

Strand: Direct

Name: mutA [H]

Synonym: TBFG_11522

Alternate gene names: 148822713

Gene position: 1686770-1688641 (Clockwise)

Preceding gene: 148822711

Following gene: 148822714

Centisome position: 38.12

GC content: 70.09

Gene sequence:

>1872_bases
TTGCTGGGAAAACAGGAGCAGTCGGTGTCCATTGATGTACCCGAGCGTGCCGACCTAGAACAGGTTCGCGGGCGCTGGCG
CAACGCGGTTGCCGGTGTGCTGTCCAAGAGCAACCGTACCGACTCAGCACAACTCGGCGATCACCCCGAGCGGCTGCTGG
ATACCCAGACCGCTGACGGGTTCGCCATCCGGGCCCTCTACACCGCGTTCGACGAGCTCCCGGAGCCGCCGTTGCCGGGC
CAGTGGCCCTTTGTGCGCGGCGGAGACCCGCTGCGCGACGTGCATTCCGGCTGGAAGGTCGCCGAGGCGTTTCCCGCCAA
CGGTGCGACGGCCGACACCAACGCGGCGGTGCTGGCCGCGCTCGGCGAGGGGGTCAGCGCGCTGCTGATCCGGGTGGGGG
AGTCGGGTGTGGCGCCTGACCGGCTCACGGCGCTGCTGTCCGGGGTGTATCTGAACCTGGCGCCGGTCATCCTCGACGCC
GGCGCCGACTACCGCCCGGCCTGCGACGTCATGCTGGCGCTGGTCGCCCAGCTCGATCCCGGCCAGCGCGACACCCTGTC
GATCGACCTGGGCGCCGACCCGCTGACGGCGTCGCTGCGCGATCGTCCCGCCCCGCCGATCGAGGAGGTCGTCGCGGTCG
CATCCCGGGCGGCCGGCGAACGTGGGCTTCGTGCGATCACCGTCGACGGACCGGCCTTCCACAACCTGGGCGCGACCGCG
GCCACCGAACTCGCGGCCACCGTCGCGGCCGCGGTGGCCTACCTGCGGGTGCTCACCGAATCCGGGCTCGTGGTGAGTGA
CGCGCTGCGGCAGATCAGCTTCCGGCTCGCCGCCGACGACGACCAGTTCATGACGCTGGCCAAGATGCGGGCTCTACGTC
AACTGTGGGCGCGGGTCGCCGAGGTCGTGGGCGACCCGGGTGGCGGCGCGGCCGTCGTGCACGCGGAGACGTCGCTACCG
ATGATGACCCAGCGTGATCCGTGGGTGAACATGCTGCGCTGCACGCTGGCGGCCTTCGGCGCCGGTGTCGGTGGCGCGGA
CACCGTGCTGGTGCACCCGTTCGACGTGGCGATTCCCGGCGGCTTTCCCGGCACGGCGGCCGGCTTTGCGCGCCGGATCG
CTCGCAACACCCAACTGCTGCTTTTAGAAGAGTCGCATGTCGGCAGGGTGCTCGATCCCGCCGGCGGGTCGTGGTTCGTC
GAAGAGCTCACCGACCGGCTGGCTCGGCGCGCCTGGCAGCGTTTCCAGGCCATCGAGGCCCGTGGCGGCTTCGTCGAGGC
CCACGACTTCCTGGCCGGCCAGATCGCCGAGTGCGCCGCCCGCCGCGCCGACGACATCGCCCATCGGCGCCTGGCGATCA
CCGGCGTCAACGAATACCCGAACCTGGGCGAACCCGCGCTGCCGCCCGGTGATCCGACATCGCCGGTGCGCCGCTACGCT
GCCGGATTCGAAGCATTGCGCGATCGATCCGATCACCACCTAGCCCGCACTGGCGCACGGCCGCGGGTGCTGTTGCTGCC
GTTGGGTCCGCTGGCCGAGCACAACATCCGGACGACCTTCGCCACCAACCTGCTGGCGTCCGGCGGCATCGAGGCGATCG
ACCCGGGAACGGTTGATGCGGGCACCGTCGGGAATGCCGTTGCCGATGCCGGTTCGCCCAGCGTTGCCGTGATCTGCGGC
ACCGATGCGCGCTACCGGGACGAGGTTGCCGACATTGTGCAAGCGGCCCGAGCCGCCGGTGTTTCGAGGGTGTACCTCGC
GGGTCCCGAGAAGGCGTTGGGAGATGCCGCACACCGGCCCGACGAGTTTTTGACCGCGAAAATCAATGTGGTGCAAGCCT
TGTCGAATCTGCTGACGCGGTTGGGGGCCTAG

Upstream 100 bases:

>100_bases
GGCCGCGATTGCCGCACCTGGGCGTCTATATGGGCGTCCCGATCAACTAGCCTTATTAGTTAAGTGACAATCCCGAAGCA
AGCCCAAGCAACATCGCTAA

Downstream 100 bases:

>100_bases
ATGACAACCAAGACACCCGTGATCGGCAGCTTCGCCGGCGTTCCGCTGCATAGCGAGCGTGCCGCGCAATCGCCCACAGA
GGCCGCGGTGCACACGCATG

Product: methylmalonyl-CoA mutase small subunit mutA

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MLGKQEQSVSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPG
QWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDA
GADYRPACDVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATA
ATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLP
MMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
EELTDRLARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYA
AGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICG
TDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA

Sequences:

>Translated_623_residues
MLGKQEQSVSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPG
QWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDA
GADYRPACDVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATA
ATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLP
MMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
EELTDRLARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYA
AGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICG
TDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA
>Mature_623_residues
MLGKQEQSVSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPG
QWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDA
GADYRPACDVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATA
ATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLP
MMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
EELTDRLARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYA
AGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICG
TDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=486, Percent_Identity=28.1893004115226, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1789284, Length=468, Percent_Identity=28.2051282051282, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25144500, Length=445, Percent_Identity=26.2921348314607, Blast_Score=138, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65615; Mature: 65615

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00544 METMALONYL_COA_MUTASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGKQEQSVSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADG
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCC
FAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCEEHHCCCCCCCCCCCCHHHHHH
LGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDP
HHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCC
GQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATA
CCCCEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCHHH
ATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHH
EVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPG
HHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECEEEEECC
GFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEA
CCCCHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYA
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
AGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDA
HHHHHHHCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
GTVGNAVADAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRP
CCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCC
DEFLTAKINVVQALSNLLTRLGA
CHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGKQEQSVSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADG
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCC
FAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCEEHHCCCCCCCCCCCCHHHHHH
LGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDP
HHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCC
GQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATA
CCCCEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCHHH
ATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHH
EVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPG
HHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECEEEEECC
GFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEA
CCCCHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYA
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
AGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDA
HHHHHHHCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
GTVGNAVADAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRP
CCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCC
DEFLTAKINVVQALSNLLTRLGA
CHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]