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The map label for this gene is mutM [H]

Identifier: 148822152

GI number: 148822152

Start: 1057567

End: 1058067

Strand: Direct

Name: mutM [H]

Synonym: TBFG_10961

Alternate gene names: 148822152

Gene position: 1057567-1058067 (Clockwise)

Preceding gene: 148822148

Following gene: 148822153

Centisome position: 23.9

GC content: 66.27

Gene sequence:

>501_bases
TTGTCATCGTCGGCAGGGGTGCTGGTGGCCGGGACGCCGCAGCCGCGCGCGCTCGGGCCCGATGCGCTGGACGTCAGCAC
CGACGACCTGGCCGGGCTGTTGGCCGGCAACACCGGCCGGATCAAGACCGTCATCACCGACCAGAAGGTAATTGCCGGCA
TCGGCAACGCCTATAGTGACGAAATCCTGCACGTCGCGAAGATCTCGCCGTTCGCCACGGCCGGCAAGTTATCCGGCGCA
CAGCTCACCTGCCTGCATGAGGCGATGGCGTCGGTGCTGTCGGACGCGGTGCGCCGGTCCGTCGGCCAGGGCGCGGCCAT
GCTCAAAGGGGAGAAACGTTCTGGGCTTCGAGTACATGCGCGCACCGGGTTACCCTGCCCAGTGTGCGGTGACACCGTGC
GGGAGGTGTCCTTCGCGGACAAGTCTTTTCAGTACTGTCCAACGTGTCAGACCGGTGGCAAGGCGCTGGCCGACCGGCGT
ATGTCGCGGCTGCTCAAGTAG

Upstream 100 bases:

>100_bases
CGCCGAAGTGGGCCTGATGGGCCCGATCGCCCGTCGCGCCTGGAAACGCACCAACTTTCTGTGACCGCGACGCTCGGCCT
CGCTGACGCCGGCCACCGCA

Downstream 100 bases:

>100_bases
TCGATATGCTCACCGGAGTGACTCGCCAGAAGATCCTGATCACCGGCGCCAGTTCCGGCCTGGGCGCCGGGATGGCCCGA
TCCTTCGCCGCCCAGGGCCG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSSSAGVLVAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGA
QLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRR
MSRLLK

Sequences:

>Translated_166_residues
MSSSAGVLVAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGA
QLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRR
MSRLLK
>Mature_165_residues
SSSAGVLVAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGAQ
LTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRM
SRLLK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=144, Percent_Identity=34.0277777777778, Blast_Score=68, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 17196; Mature: 17065

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS51066 ZF_FPG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSAGVLVAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSD
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCHHH
EILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHA
HHEEHECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCEEEE
RTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSAGVLVAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSD
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCHHH
EILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHA
HHEEHECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCEEEE
RTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA