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The map label for this gene is cusS [C]

Identifier: 148821803

GI number: 148821803

Start: 701132

End: 702265

Strand: Reverse

Name: cusS [C]

Synonym: TBFG_10612

Alternate gene names: 148821803

Gene position: 702265-701132 (Counterclockwise)

Preceding gene: 148821804

Following gene: 148821802

Centisome position: 15.87

GC content: 69.75

Gene sequence:

>1134_bases
GTGGCCCATCCGATGGCGACTCACCCTCGTCTTCAGCGCCGCCATGGCGCTCGTTCTGGCAGCAGCCGGTGCCGTCACCG
TCGTCCAGTTCCGCGACGCCGCTCACGAAGCCGACCCCGATGGCGCGCTGCGCGGGCTCACCGACGACATCACCGCCGAT
CTGGTCCGGGAATTGGTGACCATCCTGCCGATCGTGCTCGTCATCGCCGCGGTGGCCGCCTACCTGCTCAGCCGCGCCGC
GCTGCGGCCCGTCGACCGGATCCGCGCGGCGGCGCAAACACTGACCACCACGCCGCACCCCGACACCGACGCGCCGCTGC
CGGTACCTCCCACCGACGACGAGATCGCTTGGCTAGCAACGACTCTCAACACCATGCTCACCCGACTGCAACGGGCCCTC
GCCCACGAACAACAGTTCGTCGCCGACGCCAGCCACGAATTACGCACCCCGTTGGCACTGCTGACCACCGAACTCGAACT
GCGCTGCGCCGGCCCAGACCCGCCGACCAGCTGAGCGCCGCCCTGCGCTCCGCGCTCGAAGAAACCCGCCGGCTCAGCGG
ACTGGCCGACCAACTGCTCACCCTGGCCCGCGCCGACCGCCCCGAATCCCACCCCTCCGCCAAAGCGGTGCCGATCACTC
CCCTGCTGCACGAGAGCGTGGCCCGCTTCGCCGCTACTGGAGCGGACATCACCACACGCGCGGAACCGGACCTGTTCGTC
TCGATCGATCCGGACCACCTGCGCCGAATCCTCACCGCCGTGCTCGACAACGCCATCACCCACGGGGACGGTGAAATCGC
TGTCACCGCGCACGCCCGCGACGGTGCAGTCGACATCGGCGTCCGCGACCACGGCCCCGGATTCGCCGACCACTTTCTTC
CCGTCGCCTTCGACCGATTCACCCGCGCCGACACCGCCCGCGGCGGTCGCGGCAGCGGCCTCGGCCTGGCCATCGTCGCC
GCCCTCACCACCACCCACGGCGGACATGCCAACGCCACCAACCACCCCGACGGCGGGGCCGAACTCCGCATCACCCTCCC
CACACCGCGGCCGCCCTTCCACGAGGAGCTTCCGCGGATCACGTCATCAGATACAAAGGACCCGAATCGGGAGCACGACA
CTAGCGACCAATAG

Upstream 100 bases:

>100_bases
CAAGATCGACCGGCCCTTCGGCGTCACCTCGCTGGAAACCATTCGCGGTGCCGGATACCGGCTGCGCAAGGACGGAGGAC
GGCATGCGCTCCCCCGCTGA

Downstream 100 bases:

>100_bases
TCGCCACGCCGCGCCGCAGCTGACGGTGTGGTCGTCGGGGTCGTGGTAACGGCGGTGAGTCGACTTCCGCACCTGAGTGG
GAAGCCATTGGTATCGTATT

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAHPMATHPRLQRRHGARSGSSRCRHRRPVPRRRSRSRPRWRAARAHRRHHRRSGPGIGDHPADRARHRRGGRLPAQPRR
AAARRPDPRGGANTDHHAAPRHRRAAAGTSHRRRDRLASNDSQHHAHPTATGPRPRTTVRRRRQPRITHPVGTADHRTRT
ALRRPRPADQLSAALRSALEETRRLSGLADQLLTLARADRPESHPSAKAVPITPLLHESVARFAATGADITTRAEPDLFV
SIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVA
ALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ

Sequences:

>Translated_377_residues
MAHPMATHPRLQRRHGARSGSSRCRHRRPVPRRRSRSRPRWRAARAHRRHHRRSGPGIGDHPADRARHRRGGRLPAQPRR
AAARRPDPRGGANTDHHAAPRHRRAAAGTSHRRRDRLASNDSQHHAHPTATGPRPRTTVRRRRQPRITHPVGTADHRTRT
ALRRPRPADQLSAALRSALEETRRLSGLADQLLTLARADRPESHPSAKAVPITPLLHESVARFAATGADITTRAEPDLFV
SIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVA
ALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ
>Mature_376_residues
AHPMATHPRLQRRHGARSGSSRCRHRRPVPRRRSRSRPRWRAARAHRRHHRRSGPGIGDHPADRARHRRGGRLPAQPRRA
AARRPDPRGGANTDHHAAPRHRRAAAGTSHRRRDRLASNDSQHHAHPTATGPRPRTTVRRRRQPRITHPVGTADHRTRTA
LRRPRPADQLSAALRSALEETRRLSGLADQLLTLARADRPESHPSAKAVPITPLLHESVARFAATGADITTRAEPDLFVS
IDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVAA
LTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ

Specific function: Member of the two-component system HK/tcrA. Phosphorylates tcrA

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786783, Length=206, Percent_Identity=33.9805825242718, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=129, Percent_Identity=35.6589147286822, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788393, Length=178, Percent_Identity=30.3370786516854, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=30.8035714285714, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=182, Percent_Identity=31.8681318681319, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=204, Percent_Identity=27.9411764705882, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HK12_MYCTU (Q7D9K1)

Other databases:

- EMBL:   AE000516
- RefSeq:   NP_335040.1
- ProteinModelPortal:   Q7D9K1
- EnsemblBacteria:   EBMYCT00000069938
- GeneID:   925027
- GenomeReviews:   AE000516_GR
- KEGG:   mtc:MT0630
- TIGR:   MT0630
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG571207
- ProtClustDB:   CLSK799725
- GO:   GO:0016020
- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF02518 HATPase_c; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 41548; Mature: 41417

Theoretical pI: Translated: 12.37; Mature: 12.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHPMATHPRLQRRHGARSGSSRCRHRRPVPRRRSRSRPRWRAARAHRRHHRRSGPGIGD
CCCCCCCCHHHHHHHCCCCCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
HPADRARHRRGGRLPAQPRRAAARRPDPRGGANTDHHAAPRHRRAAAGTSHRRRDRLASN
CCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCC
DSQHHAHPTATGPRPRTTVRRRRQPRITHPVGTADHRTRTALRRPRPADQLSAALRSALE
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
ETRRLSGLADQLLTLARADRPESHPSAKAVPITPLLHESVARFAATGADITTRAEPDLFV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCEEE
SIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRF
EECHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHH
TRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRI
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCC
TSSDTKDPNREHDTSDQ
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AHPMATHPRLQRRHGARSGSSRCRHRRPVPRRRSRSRPRWRAARAHRRHHRRSGPGIGD
CCCCCCCHHHHHHHCCCCCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
HPADRARHRRGGRLPAQPRRAAARRPDPRGGANTDHHAAPRHRRAAAGTSHRRRDRLASN
CCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCC
DSQHHAHPTATGPRPRTTVRRRRQPRITHPVGTADHRTRTALRRPRPADQLSAALRSALE
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
ETRRLSGLADQLLTLARADRPESHPSAKAVPITPLLHESVARFAATGADITTRAEPDLFV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCEEE
SIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRF
EECHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHH
TRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRI
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCC
TSSDTKDPNREHDTSDQ
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12218036