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The map label for this gene is pstP [H]

Identifier: 148821209

GI number: 148821209

Start: 21738

End: 23282

Strand: Reverse

Name: pstP [H]

Synonym: TBFG_10018

Alternate gene names: 148821209

Gene position: 23282-21738 (Counterclockwise)

Preceding gene: 148821210

Following gene: 148821208

Centisome position: 0.53

GC content: 67.51

Gene sequence:

>1545_bases
GTGGCGCGCGTGACCCTGGTCCTGCGATACGCGGCGCGCAGCGATCGCGGCTTGGTACGCGCCAACAACGAAGACTCGGT
CTACGCTGGGGCACGGCTATTGGCCCTGGCCGACGGCATGGGTGGGCATGCGGCCGGCGAGGTGGCGTCCCAGTTGGTGA
TTGCCGCATTGGCCCATCTCGATGACGACGAGCCCGGTGGCGATCTGCTGGCCAAGCTGGATGCCGCGGTGCGCGCCGGC
AACTCGGCTATCGCAGCGCAAGTCGAGATGGAGCCCGATCTCGAAGGCATGGGTACCACGCTCACCGCAATCCTGTTCGC
GGGCAACCGGCTCGGCCTGGTGCATATCGGTGACTCGCGCGGTTACCTGCTGCGCGACGGTGAGCTGACGCAGATCACCA
AGGACGACACGTTTGTCCAAACGCTGGTCGACGAAGGCCGGATCACCCCGGAGGAGGCGCACAGCCACCCGCAACGCTCG
TTGATCATGCGGGCGTTGACCGGCCATGAGGTCGAACCGACGCTGACCATGCGAGAAGCCCGCGCCGGTGATCGTTACCT
GCTGTGCTCGGACGGGTTGTCCGATCCGGTTAGCGATGAAACTATCCTCGAGGCCCTGCAGATCCCCGAGGTTGCCGAGA
GCGCTCACCGCCTCATTGAACTGGCGCTGCGCGGCGGCGGCCCCGACAACGTCACTGTCGTCGTCGCCGACGTCGTCGAC
TACGACTACGGCCAGACCCAACCGATTCTGGCCGGGGCGGTCTCAGGCGACGACGACCAACTGACCCTGCCCAACACCGC
CGCCGGCCGGGCCTCTGCCATCAGCCAGCGCAAGGAGATCGTTAAACGCGTTCCGCCACAGGCCGATACATTCAGTCGGC
CACGGTGGTCGGGCCGACGGCTAGCATTCGTTGTCGCACTGGTGACCGTGCTGATGACTGCGGGCCTGCTCATTGGTCGC
GCGATCATCCGCAGCAACTACTACGTAGCGGACTACGCCGGCAGCGTGTCCATCATGCGGGGGATTCAAGGGTCGCTACT
GGGCATGTCCCTGCACCAGCCTTACCTGATGGGCTGCCTCAGCCCGCGTAACGAGCTGTCGCAGATCAGCTACGGACAGT
CTGGGGGCCCTCTCGACTGCCATCTGATGAAACTGGAGGATCTGCGACCGCCGGAGCGCGCACAGGTTCGGGCCGGTCTC
CCGGCCGGCACTCTCGATGACGCCATCGGGCAGTTGCGCGAACTGGCGGCCAACTCCCTGCTGCCGCCTTGCCCGGCGCC
GCGTGCCACGTCCCCGCCCGGGCGCCCGGCCCCACCCACCACCAGCGAGACAACCGAACCAAACGTCACCTCCTCGCCAG
CCTCTCCATCACCCACCACCTCCGCGTCGGCCCCCACCGGAACTACTCCTGCCATCCCCACGAGTGCCTCCCCGGCAGCG
CCCGCGTCGCCGCCGACGCCTTGGCCCGTCACCAGCTCGCCGACGATGGCCGCACTTCCGCCACCCCCGCCTCAGCCGGG
CATCGACTGCCGGGCGGCGGCATGA

Upstream 100 bases:

>100_bases
TTGCGCCCGTGACCCGCGCTGGCGACGATGCAGAGCGCAGAGAAGCGGTGGGGGCGCGCCCCCACAAGTGGGGGGTACCC
CCACCCGCTTGCGGGGGAGA

Downstream 100 bases:

>100_bases
CGACACGACTGCAAGCGCCGGTGGCCGTAACGCCCCCGTTGCCGACTCGGCGCAACGCTGAACTGCTGCTGCTGTGCTTT
GCCGCCGTAATCACGTTTGC

Product: serine/threonine phosphatase ppp

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAG
NSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGR
AIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGL
PAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSASAPTGTTPAIPTSASPAA
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA

Sequences:

>Translated_514_residues
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAG
NSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGR
AIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGL
PAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSASAPTGTTPAIPTSASPAA
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
>Mature_513_residues
ARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGN
SAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSL
IMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDY
DYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRA
IIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLP
AGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSASAPTGTTPAIPTSASPAAP
ASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 53802; Mature: 53671

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHL
CCEEEEEEEEHHCCCCCEEEECCCCCHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSR
CCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREA
CEEEECCCEEEEECCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEHHHH
RAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
CCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRR
CCCCCCCCEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
LAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCHHCCHHHCCHHHHHHC
SPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSL
CCHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
LPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSASAPTGTTPAIPTSASPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHL
CEEEEEEEEHHCCCCCEEEECCCCCHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSR
CCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREA
CEEEECCCEEEEECCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEHHHH
RAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVD
CCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
YDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRR
CCCCCCCCEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
LAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCHHCCHHHCCHHHHHHC
SPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSL
CCHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
LPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSASAPTGTTPAIPTSASPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]