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The map label for this gene is hpt [H]

Identifier: 148663487

GI number: 148663487

Start: 4071701

End: 4072351

Strand: Reverse

Name: hpt [H]

Synonym: MRA_3660

Alternate gene names: 148663487

Gene position: 4072351-4071701 (Counterclockwise)

Preceding gene: 148663488

Following gene: 148663485

Centisome position: 92.14

GC content: 64.67

Gene sequence:

>651_bases
TTGACGCCCGCGTTGGTCGTTGGTCCCGCGGCGTGGCACGCTGTGCACGTGACCCAGAGCTCCTCGGCGATCACCCCCGG
GCAGACGGCGGAGCTTTATCCGGGGGACATCAAGTCGGTGCTGCTCACGGCCGAGCAGATTCAGGCCCGCATCGCCGAGC
TCGGCGAGCAGATCGGCAACGACTACCGCGAGCTGTCCGCTACCACCGGCCAGGATCTGCTGCTGATCACCGTGCTGAAG
GGCGCGGTGCTCTTCGTCACCGACCTGGCGCGAGCGATTCCCGTGCCGACCCAGTTCGAGTTCATGGCGGTGAGTTCGTA
TGGGTCATCGACATCCTCGTCGGGCGTGGTGCGGATCCTCAAGGACCTCGACCGCGACATCCACGGCCGCGACGTGCTGA
TCGTCGAGGACGTCGTCGACTCCGGCCTTACGCTTTCGTGGTTGTCGCGGAACCTGACGAGCCGGAATCCGCGGTCATTG
CGGGTGTGCACGCTGCTGCGCAAGCCCGATGCGGTGCACGCCAACGTCGAAATCGCGTACGTGGGTTTCGACATTCCCAA
CGACTTCGTCGTGGGCTACGGCCTGGACTACGACGAACGCTACCGTGACCTGTCATACATCGGGACGCTGGACCCCAGGG
TCTATCAGTAG

Upstream 100 bases:

>100_bases
GGCGCGGTCAGGGCGGGGTAGCGGTTGGGTCCACGTTGCGCGGTCAGCGACTGGTCGCCGGGCGGCGCGACGGCGTACTT
GTGTTGCGGCGCGAGCCCGT

Downstream 100 bases:

>100_bases
GCGGCTAGGTCAGTTCCCAGACCACCGTGACCGAGAAGCCCACCGTCTGCTGGCCGGGTTCCAGCGGCACCGCGGATAGG
CCGCGCGGCGGCGCCGGCGC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTPALVVGPAAWHAVHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLK
GAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSL
RVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ

Sequences:

>Translated_216_residues
MTPALVVGPAAWHAVHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLK
GAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSL
RVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
>Mature_215_residues
TPALVVGPAAWHAVHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKG
AVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLR
VCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=188, Percent_Identity=33.5106382978723, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI4504483, Length=184, Percent_Identity=30.4347826086957, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=49.4186046511628, Blast_Score=177, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17510817, Length=193, Percent_Identity=31.6062176165803, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 23622; Mature: 23491

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPALVVGPAAWHAVHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGN
CCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRIL
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHH
KDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAY
HHHCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEEE
VGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
EEECCCCCEEEEECCCHHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure 
TPALVVGPAAWHAVHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGN
CCCEEECCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRIL
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHH
KDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAY
HHHCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEEE
VGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
EEECCCCCEEEEECCCHHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]