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The map label for this gene is fadA6 [H]

Identifier: 148663419

GI number: 148663419

Start: 4004470

End: 4005630

Strand: Reverse

Name: fadA6 [H]

Synonym: MRA_3595

Alternate gene names: 148663419

Gene position: 4005630-4004470 (Counterclockwise)

Preceding gene: 148663420

Following gene: 148663418

Centisome position: 90.63

GC content: 66.67

Gene sequence:

>1161_bases
ATGACAGAGGCGTACGTCATCGACGCCGTACGGACCGCGGTCGGCAAGCGGGGCGGCGCACTGGCCGGTATCCATCCCGT
CGACCTGGGTGCCCTGGCCTGGCGCGGACTGCTGGACCGGACCGACATCGACCCCGCCGCCGTCGACGACGTGATCGCCG
GATGTGTCGACGCCATCGGCGGACAGGCGGGCAACATCGCCCGACTGTCGTGGCTGGCCGCCGGCTATCCCGAAGAGGTC
CCCGGTGTCACCGTGGACCGCCAGTGCGGATCCAGCCAGCAGGCGATTTCCTTTGGCGCGCAGGCGATCATGTCCGGCAC
GGCGGATGTCATCGTGGCCGGCGGCGTGCAGAACATGAGCCAGATCCCGATCTCGTCGGCGATGACCGTGGGCGAACAGT
TCGGGTTCACCTCGCCGACCAACGAATCCAAGCAATGGTTACACCGGTATGGCGACCAGGAGATTTCACAGTTCCGTGGC
TCGGAGCTGATCGCCGAGAAGTGGAACCTGTCCCGTGAAGAGATGGAGCGGTACTCGCTGACCAGCCACGAACGCGCGTT
CGCGGCGATCCGCGCCGGCCACTTCGAAAACGAAATCATCACTGTGGAAACCGAATCCGGGCCGTTCCGGGTTGATGAGG
GCCCGCGGGAGTCGTCGCTGGAGAAGATGGCCGGCTTGCAGCCGCTGGTCGAGGGCGGCCGGCTGACGGCGGCGATGGCC
AGTCAGATCTCCGACGGCGCCAGTGCAGTGTTGCTGGCCTCCGAGCGGGCCGTCAAAGACCATGGACTTAGGCCCCGTGC
CCGCATCCACCACATCAGTGCGCGCGCCGCCGACCCGGTATTCATGCTGACCGGACCCATCCCCGCCACCCGGTACGCGC
TGGACAAGACCGGGCTTGCCATCGACGACATCGACACCGTCGAGATCAACGAGGCGTTCGCGCCGGTAGTTATGGCCTGG
CTCAAGGAAATCAAGGCCGACCCGGCGAAGGTCAACCCCAACGGCGGCGCGATCGCGCTGGGGCATCCGCTAGGCGCCAC
CGGCGCCAAACTGTTCACCACCATGCTGGGCGAGCTGGAGCGCATCGGTGGCCGCTACGGGCTGCAGACCATGTGCGAGG
GCGGCGGCACCGCCAACGTCACCATTATCGAGCGGCTGTAG

Upstream 100 bases:

>100_bases
ATCGTGCTTGGCGGGATCACCAAAGAGGGAGTCTGAAATGCCCCGTGTCGACGACGATGCGGTGGGGGTACCACTCACTG
GCAACGGGAGAGGAGCGGTT

Downstream 100 bases:

>100_bases
GCCTTCGTTGGCGCCGAGGGTGAATCTCACGACGGGTCGTCGGCGTGTCGCGTCGTGCGATTCACTGTCGGCGGGGTGTC
GGTGGGTGATGCCAGGATGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEV
PGVTVDRQCGSSQQAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRG
SELIAEKWNLSREEMERYSLTSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEKMAGLQPLVEGGRLTAAMA
SQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAW
LKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGLQTMCEGGGTANVTIIERL

Sequences:

>Translated_386_residues
MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEV
PGVTVDRQCGSSQQAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRG
SELIAEKWNLSREEMERYSLTSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEKMAGLQPLVEGGRLTAAMA
SQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAW
LKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGLQTMCEGGGTANVTIIERL
>Mature_385_residues
TEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDPAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVP
GVTVDRQCGSSQQAISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGS
ELIAEKWNLSREEMERYSLTSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEKMAGLQPLVEGGRLTAAMAS
QISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAWL
KEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGLQTMCEGGGTANVTIIERL

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=39.0745501285347, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=38.2278481012658, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=33.587786259542, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=33.2558139534884, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=34.9367088607595, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=27.6041666666667, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=38.7254901960784, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=38.8471177944862, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082165, Length=395, Percent_Identity=36.9620253164557, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1788554, Length=399, Percent_Identity=38.0952380952381, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1788683, Length=406, Percent_Identity=29.064039408867, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=37.5634517766497, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=32.2418136020151, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=30.2564102564103, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=30.4245283018868, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=28.1653746770026, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=35.264483627204, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=392, Percent_Identity=31.8877551020408, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=36.5239294710327, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=37.5321336760925, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=32.8282828282828, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=32.1596244131455, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40903; Mature: 40772

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDPAAVDDVIAGCVDAIG
CCCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
GQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADVIVAGGVQNMS
CCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHH
QIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSL
HCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCHHHHHHHCC
TSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEKMAGLQPLVEGGRLTAAMA
CHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHCCHHHHCCCCHHHHHH
SQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLA
HHHCCCCCEEEEECCHHHHHCCCCCHHHHEEHHHCCCCCEEEEECCCCHHHHHHHCCCCE
IDDIDTVEINEAFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELE
ECCCCEEEHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHH
RIGGRYGLQTMCEGGGTANVTIIERL
HHCCCCCHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
TEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDPAAVDDVIAGCVDAIG
CCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
GQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADVIVAGGVQNMS
CCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHH
QIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSL
HCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCHHHHHHHCC
TSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEKMAGLQPLVEGGRLTAAMA
CHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHCCHHHHCCCCHHHHHH
SQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLA
HHHCCCCCEEEEECCHHHHHCCCCCHHHHEEHHHCCCCCEEEEECCCCHHHHHHHCCCCE
IDDIDTVEINEAFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELE
ECCCCEEEHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHH
RIGGRYGLQTMCEGGGTANVTIIERL
HHCCCCCHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]