BacMap

Definition	Mycobacterium tuberculosis H37Ra, complete genome.
Accession	NC_009525
Length	4,419,977

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The map label for this gene is fixR [H]

Identifier: 148663412

GI number: 148663412

Start: 3996985

End: 3997764

Strand: Reverse

Name: fixR [H]

Synonym: MRA_3588

Alternate gene names: 148663412

Gene position: 3997764-3996985 (Counterclockwise)

Preceding gene: 148663418

Following gene: 148663411

Centisome position: 90.45

GC content: 66.67

Gene sequence:

>780_bases
GTGACTCTCGCCGAGGCAGCCGACGCCATCAATTTCGGGCTGGCCGGGCGGGTGGTTTTGGTCACCGGCGGTGTCCGCGG
GGTAGGCGCGGGCATCAGCTCGGTATTCGCCGAACAGGGCGCGACCGTGATCACCTGCGCGCGACGAGCGGTCGACGGCC
AACCGTATGAGTTCCACCGCTGCGACATCCGGGACGAGGACTCGGTCAAGCGCCTGGTCGGTGAGATCGGGGAGCGGCAC
GGCCGACTCGACATGCTGGTCAACAACGCGGGCGGCTCGCCATACGCGCTGGCCGCCGAGGCGACACACAACTTCCACCG
AAAGATCGTCGAGCTCAATGTGCTTGCACCGCTGCTGGTTTCCCAGCACGCCAACGTGCTGATGCAAGCGCAGCCCAACG
GTGGGTCGATCGTAAACATCTGTAGCGTCAGCGGTCGCCGTCCCACTCCCGGCACGGCGGCCTATGGCGCGGCCAAGGCA
GGCCTGGAAAACCTGACCACCACGCTGGCGGTGGAATGGGCACCCAAGGTTCGGGTCAACGCCGTGGTGGTCGGCATGGT
GGAAACCGAACGGTCCGAACTGTTCTACGGTGATGCCGAGTCGATCGCTCGCGTCGCCGCCACGGTGCCGTTGGGCCGGC
TGGCACGACCTGCCGACATTGGTTGGGCTGCAGCGTTTTTGGCGTCCGATGCGGCGTCATATATCAGCGGGGCGACGCTC
GAGGTGCACGGCGGCGGTGAGCCGCCGCCGTACCTGGGCGCCTCGAGTGCCAACAAGTGA

Upstream 100 bases:

>100_bases
TGACCGCGACGATGCCCGGTTCGGGCGTGGTGGAGGTGATCGGCATTGCACTCCTGCGGGTTCGCTACCTAAGCAAGCAC
TTGCTTGGTACGCTAGCACA

Downstream 100 bases:

>100_bases
CGAGCAAAGGAGCAATGGGGTCATGGGCTTGGTCGACGGCCGGGTGGTCATCGTCACCGGAGCGGGTGGCGGCATCGGCC
GCGCACATGCGTTGGCCTTC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDGQPYEFHRCDIRDEDSVKRLVGEIGERH
GRLDMLVNNAGGSPYALAAEATHNFHRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKA
GLENLTTTLAVEWAPKVRVNAVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGATL
EVHGGGEPPPYLGASSANK

Sequences:

>Translated_259_residues
MTLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDGQPYEFHRCDIRDEDSVKRLVGEIGERH
GRLDMLVNNAGGSPYALAAEATHNFHRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKA
GLENLTTTLAVEWAPKVRVNAVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGATL
EVHGGGEPPPYLGASSANK
>Mature_258_residues
TLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDGQPYEFHRCDIRDEDSVKRLVGEIGERHG
RLDMLVNNAGGSPYALAAEATHNFHRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKAG
LENLTTTLAVEWAPKVRVNAVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGATLE
VHGGGEPPPYLGASSANK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=33.4677419354839, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI59889578, Length=225, Percent_Identity=34.6666666666667, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=31.0204081632653, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=31.5352697095436, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=30.5555555555556, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=30.2788844621514, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=30.1255230125523, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=28.4552845528455, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI109715829, Length=237, Percent_Identity=29.1139240506329, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=31.3186813186813, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=31.7948717948718, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4503301, Length=197, Percent_Identity=29.4416243654822, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI32455239, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI5031765, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=28.3505154639175, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=35.2713178294574, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=34.6938775510204, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=30.327868852459, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=31.8181818181818, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=31.7460317460317, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=28.1632653061224, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=31.5789473684211, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=30.1652892561983, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=28, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=29.9610894941634, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=29.8755186721992, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787545, Length=250, Percent_Identity=25.6, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=26.5873015873016, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=32.9268292682927, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=30.952380952381, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=29.8804780876494, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=31.404958677686, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=29.7619047619048, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=31.4741035856574, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=29.4354838709677, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=27.3408239700375, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=30.8270676691729, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=30.5343511450382, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=29.3233082706767, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=26.7175572519084, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=25.2, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=28.7878787878788, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=29.8850574712644, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=27.0992366412214, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=27.8810408921933, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=189, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=26.3940520446097, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=26.9961977186312, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=196, Percent_Identity=31.1224489795918, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=26.2172284644195, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=26.5917602996255, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=25.4752851711027, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=185, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322227, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=222, Percent_Identity=29.2792792792793, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=186, Percent_Identity=30.1075268817204, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=34.375, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=30.4878048780488, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=32.2709163346614, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=32.9268292682927, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=32.9457364341085, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=32.2314049586777, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24644337, Length=252, Percent_Identity=31.3492063492063, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=29.5081967213115, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358495, Length=195, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26856; Mature: 26725

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDGQPYEFHR
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCEEEE
CDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSPYALAAEATHNFHRKIVELNVLAPLLV
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
SQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKAGLENLTTTLAVEWAPKVRVN
HCCCCEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCEEEE
AVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGATL
EEEEEEEECCCCCEEECCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCEE
EVHGGGEPPPYLGASSANK
EECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVITCARRAVDGQPYEFHR
CHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCEEEE
CDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSPYALAAEATHNFHRKIVELNVLAPLLV
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
SQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKAGLENLTTTLAVEWAPKVRVN
HCCCCEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCEEEE
AVVVGMVETERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGATL
EEEEEEEECCCCCEEECCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCEE
EVHGGGEPPPYLGASSANK
EECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3313281; 11157954; 12597275 [H]