| Definition | Mycobacterium tuberculosis H37Ra, complete genome. |
|---|---|
| Accession | NC_009525 |
| Length | 4,419,977 |
Click here to switch to the map view.
The map label for this gene is fabG [C]
Identifier: 148663411
GI number: 148663411
Start: 3996048
End: 3996962
Strand: Reverse
Name: fabG [C]
Synonym: MRA_3587
Alternate gene names: 148663411
Gene position: 3996962-3996048 (Counterclockwise)
Preceding gene: 148663412
Following gene: 148663408
Centisome position: 90.43
GC content: 68.63
Gene sequence:
>915_bases ATGGGCTTGGTCGACGGCCGGGTGGTCATCGTCACCGGAGCGGGTGGCGGCATCGGCCGCGCACATGCGTTGGCCTTCGC GGCCGAGGGTGCGCGCGTGGTGGTCAACGATATCGGTGTGGGCCTGGACGGTTCGCCGGCAAGCGGCGGCAGCGCAGCCC AAGACGTGGTCGACGAGATCCTTGCGGCCGGTGGCCAAGCCGTCGCCGACGGGTCGGACATCTCGGACTGGGACCAGGCG GCCAACCTGATCCAGGCCGCCGTCGAGACGTACGGTGGTGTGGACGTCCTGGTGAACAATGCCGGCATCGTGCGGGACCG GATGATCGCCAACACCAGCGAAGAGGAGTTCGACGCTGTCATCGCGGTGCACCTCAAGGGCCACTTCGCCACCATGCGGC ACGCCGCGTCCCATTGGCGGGGACTGTCCAAGGCGGGCAAAGCCCCGAAAGACATTGACGCGCGGATCATCAACACCAGC TCTGGCGCGGGCCTACAGGGCAGCGTGGGGCAGGGCAACTACAGCGCCGCCAAGGCCGGAATCGCGGCGCTGACGCTCGT CGGCGCCGCCGAAATGAGGCGGTACGGCGTGACCGTCAACGCGATCGCGCCGGCGGCGCGCACCCGCATGACCGAGACTG TGTTCGCGGAGATGATGGCCAAGCCGCAGGAGGGGTTCGACGCGATGGCCCCGGAGAACGTCTCACCCTTGGTGGTATGG CTGGGCAGTGCGGAGTCCCGCGATGTCACTGGGAAGGTATTCGAGGTCGAGGGCGGCATCATCCGGGTCGCCGAGGGCTG GGCGCATGGCCCGCAGGTGGACAAGGGCGTGAAATGGGATCCGGCCGAGCTGGGGCCCGTCGTCAGCGACCTGTTGGCCA AGTCGCGGCCGCCGGTTCCGGTCTATGGGGCCTAG
Upstream 100 bases:
>100_bases ATCAGCGGGGCGACGCTCGAGGTGCACGGCGGCGGTGAGCCGCCGCCGTACCTGGGCGCCTCGAGTGCCAACAAGTGACG AGCAAAGGAGCAATGGGGTC
Downstream 100 bases:
>100_bases TTATCTGCGCCGAGCGTGAACTCAGGGCGAGATTTCGGCCGTTTTCTCGCCCTGGCTTCACGTTCGGCGAAGTTGGGAAC GGTCAGGGTTCGCAAACCAC
Product: short chain dehydrogenase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 304; Mature: 303
Protein sequence:
>304_residues MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQAVADGSDISDWDQA ANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTS SGAGLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKPQEGFDAMAPENVSPLVVW LGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA
Sequences:
>Translated_304_residues MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQAVADGSDISDWDQA ANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTS SGAGLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKPQEGFDAMAPENVSPLVVW LGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA >Mature_303_residues GLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQAVADGSDISDWDQAA NLIQAAVETYGGVDVLVNNAGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTSS GAGLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKPQEGFDAMAPENVSPLVVWL GSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=44.5736434108527, Blast_Score=189, Evalue=3e-48, Organism=Homo sapiens, GI15277342, Length=273, Percent_Identity=33.6996336996337, Blast_Score=106, Evalue=3e-23, Organism=Homo sapiens, GI40254992, Length=257, Percent_Identity=30.7392996108949, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI4758504, Length=210, Percent_Identity=31.9047619047619, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI31542939, Length=217, Percent_Identity=29.4930875576037, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI66933014, Length=271, Percent_Identity=28.7822878228782, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI7705925, Length=263, Percent_Identity=30.0380228136882, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI40254986, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI19923817, Length=275, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI83715985, Length=203, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=267, Percent_Identity=31.4606741573034, Blast_Score=100, Evalue=2e-22, Organism=Escherichia coli, GI1789208, Length=263, Percent_Identity=28.1368821292776, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI87082100, Length=272, Percent_Identity=29.7794117647059, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI2367175, Length=269, Percent_Identity=31.2267657992565, Blast_Score=84, Evalue=9e-18, Organism=Escherichia coli, GI1789378, Length=265, Percent_Identity=31.6981132075472, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1790717, Length=269, Percent_Identity=28.2527881040892, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1788459, Length=271, Percent_Identity=27.6752767527675, Blast_Score=78, Evalue=9e-16, Organism=Escherichia coli, GI1787905, Length=99, Percent_Identity=45.4545454545455, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789057, Length=271, Percent_Identity=27.3062730627306, Blast_Score=72, Evalue=6e-14, Organism=Escherichia coli, GI87082160, Length=201, Percent_Identity=29.3532338308458, Blast_Score=68, Evalue=9e-13, Organism=Escherichia coli, GI1786812, Length=268, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17568967, Length=251, Percent_Identity=40.2390438247012, Blast_Score=171, Evalue=4e-43, Organism=Caenorhabditis elegans, GI25147288, Length=263, Percent_Identity=34.6007604562738, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17555706, Length=270, Percent_Identity=32.5925925925926, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17564282, Length=204, Percent_Identity=30.3921568627451, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI71982365, Length=202, Percent_Identity=29.7029702970297, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17508895, Length=201, Percent_Identity=29.3532338308458, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562908, Length=232, Percent_Identity=27.1551724137931, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI72000259, Length=280, Percent_Identity=25.3571428571429, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17559104, Length=282, Percent_Identity=26.9503546099291, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17558628, Length=209, Percent_Identity=29.1866028708134, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI193203117, Length=180, Percent_Identity=30, Blast_Score=72, Evalue=5e-13, Organism=Caenorhabditis elegans, GI193204405, Length=230, Percent_Identity=28.695652173913, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17560332, Length=301, Percent_Identity=25.2491694352159, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17562906, Length=230, Percent_Identity=26.9565217391304, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=25.7575757575758, Blast_Score=71, Evalue=9e-13, Organism=Caenorhabditis elegans, GI71994604, Length=266, Percent_Identity=25.9398496240602, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193203115, Length=180, Percent_Identity=30, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17555612, Length=227, Percent_Identity=29.0748898678414, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562910, Length=296, Percent_Identity=24.6621621621622, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562904, Length=292, Percent_Identity=23.972602739726, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17538182, Length=208, Percent_Identity=31.7307692307692, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=24.8091603053435, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17563726, Length=256, Percent_Identity=25.78125, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17531453, Length=286, Percent_Identity=25.8741258741259, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=255, Percent_Identity=44.7058823529412, Blast_Score=189, Evalue=3e-49, Organism=Saccharomyces cerevisiae, GI6324126, Length=280, Percent_Identity=27.8571428571429, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI18859837, Length=272, Percent_Identity=41.1764705882353, Blast_Score=177, Evalue=1e-44, Organism=Drosophila melanogaster, GI24639444, Length=266, Percent_Identity=31.203007518797, Blast_Score=101, Evalue=8e-22, Organism=Drosophila melanogaster, GI21357673, Length=255, Percent_Identity=27.843137254902, Blast_Score=84, Evalue=2e-16, Organism=Drosophila melanogaster, GI17737361, Length=237, Percent_Identity=29.1139240506329, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21357041, Length=201, Percent_Identity=30.3482587064677, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI23397609, Length=272, Percent_Identity=28.3088235294118, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24644339, Length=267, Percent_Identity=28.4644194756554, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI28571526, Length=272, Percent_Identity=27.2058823529412, Blast_Score=75, Evalue=7e-14, Organism=Drosophila melanogaster, GI24649181, Length=178, Percent_Identity=31.4606741573034, Blast_Score=73, Evalue=3e-13, Organism=Drosophila melanogaster, GI281364892, Length=215, Percent_Identity=29.3023255813954, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI21356301, Length=201, Percent_Identity=29.8507462686567, Blast_Score=69, Evalue=5e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 31070; Mature: 30939
Theoretical pI: Translated: 4.88; Mature: 4.88
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEI CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH LAAGGQAVADGSDISDWDQAANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSEEEFDAV HHCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEE IAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGAGLQGSVGQGNYSAAKAG EEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHH IAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKPQEGFDAMAPENVSPLVVW HHHHHHHHHHHHHHHCEEEEHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE LGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVP ECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC VYGA CCCC >Mature Secondary Structure GLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEI CCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH LAAGGQAVADGSDISDWDQAANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSEEEFDAV HHCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEE IAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTSSGAGLQGSVGQGNYSAAKAG EEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHH IAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEMMAKPQEGFDAMAPENVSPLVVW HHHHHHHHHHHHHHHCEEEEHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE LGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVP ECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC VYGA CCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9634230 [H]