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The map label for this gene is glmS

Identifier: 148663301

GI number: 148663301

Start: 3863693

End: 3865567

Strand: Reverse

Name: glmS

Synonym: MRA_3477

Alternate gene names: 148663301

Gene position: 3865567-3863693 (Counterclockwise)

Preceding gene: 148663304

Following gene: 148663300

Centisome position: 87.46

GC content: 66.72

Gene sequence:

>1875_bases
GTGTGCGGAATTGTCGGTTACGTCGGGCGGCGCCCCGCCTACGTCGTCGTCATGGACGCGCTGCGCCGGATGGAGTACCG
CGGCTACGACTCGTCGGGCATCGCGCTGGTCGACGGTGGCACACTCACCGTGCGCCGGCGTGCGGGCCGGCTGGCCAACC
TCGAGGAAGCCGTGGCGGAAATGCCGTCCACGGCGCTGTCCGGTACTACCGGCCTGGGCCACACCCGCTGGGCCACCCAC
GGTCGTCCCACCGACCGCAACGCGCACCCGCACCGCGACGCTGCCGGCAAGATCGCCGTCGTCCACAACGGCATCATCGA
GAACTTCGCCGTCTTGCGCCGGGAGCTGGAGACTGCCGGTGTCGAGTTTGCCAGCGACACCGATACCGAGGTCGCGGCGC
ACCTGGTGGCGCGGGCGTATCGGCACGGCGAGACGGCCGATGACTTCGTCGGCTCCGTACTTGCCGTGCTGCGCCGGCTT
GAGGGGCATTTCACGCTCGTGTTCGCCAATGCCGACGACCCCGGCACCCTCGTGGCGGCCCGCCGTTCCACGCCCCTGGT
GCTGGGCATCGGCGACAACGAGATGTTCGTCGGTTCCGACGTGGCCGCGTTTATCGAGCACACCCGGGAAGCGGTCGAGC
TCGGCCAGGACCAGGCGGTGGTGATCACCGCCGACGGCTACCGGATCAGCGATTTCGACGGCAACGATGGCCTACAAGCT
GGGCGCGATTTCCGCCCCTTCCACATCGACTGGGATCTGGCTGCCGCCGAAAAGGGCGGCTACGAGTACTTCATGCTCAA
GGAGATCGCCGAGCAGCCCGCCGCGGTGGCCGACACCTTGCTCGGACACTTCGTGGGTGGCCGGATCGTGCTCGACGAGC
AGCGGTTGAGCGACCAGGAACTGCGCGAGATCGACAAGGTGTTCGTGGTGGCCTGCGGTACCGCATATCACTCCGGGCTG
CTGGCCAAGTACGCGATCGAGCACTGGACGCGGCTGCCCGTGGAAGTGGAACTCGCCAGCGAGTTTCGGTATCGGGATCC
GGTGTTGGACCGTAGCACCTTGGTGGTGGCGATCTCGCAGTCCGGGGAAACCGCCGACACGCTGGAAGCGGTCCGACACG
CCAAGGAGCAGAAAGCCAAGGTGCTGGCGATCTGCAACACCAACGGCTCGCAGATCCCGCGCGAGTGCGACGCGGTGCTC
TACACCCGCGCCGGCCCGGAGATCGGTGTGGCGTCCACAAAAACGTTTCTGGCGCAGATTGCTGCCAACTATCTGCTCGG
CCTTGCCTTGGCGCAGGCCCGCGGCACCAAATACCCCGACGAGGTCGAGCGCGAGTACCACGAACTGGAAGCGATGCCGG
ACCTGGTGGCCCGGGTGATCGCGGCGACCGGACCGGTGGCCGAGCTGGCCCACCGGTTCGCCCAGTCGTCGACCGTGCTG
TTCCTGGGTCGCCATGTCGGCTATCCGGTGGCGCTGGAGGGTGCACTCAAACTCAAGGAGTTGGCCTACATGCACGCCGA
GGGTTTCGCGGCCGGCGAGCTCAAGCACGGCCCGATCGCGCTGATCGAAGACGGCCTACCGGTCATCGTCGTCATGCCCT
CACCCAAGGGGTCGGCCACGCTGCACGCCAAGCTGCTGTCCAACATCCGTGAAATCCAGACCCGCGGTGCGGTGACCATC
GTGATCGCCGAGGAGGGCGACGAAACGGTGCGCCCCTACGCCGATCACCTGATCGAAATCCCAGCGGTGTCAACGCTATT
GCAGCCGCTGCTATCAACCATTCCGCTTCAGGTGTTCGCGGCTTCGGTGGCGCGCGCCCGCGGCTACGATGTCGACAAGC
CGCGGAATCTGGCCAAGTCCGTCACCGTCGAATAG

Upstream 100 bases:

>100_bases
ACAAGTGTTGGCCTTTCGTGCGCGGTGGCCAAACTCGACGATAGCGTCGGTTGGGCGACGGGACTGCCCTACCGACCATG
CTGCACTACCCTGGTCTGCT

Downstream 100 bases:

>100_bases
TCGAGGTGGCTCACGGTACGGGACCTGGCGGCCCAAGACACTCGACGCGATCCACGTGGCGACCGCGGAGACGTTGGGTG
CGGAGTTGACGGCGATGATC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATH
GRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRL
EGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQA
GRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGL
LAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVL
YTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVL
FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTI
VIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE

Sequences:

>Translated_624_residues
MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATH
GRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRL
EGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQA
GRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGL
LAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVL
YTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVL
FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTI
VIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE
>Mature_624_residues
MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATH
GRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRL
EGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQA
GRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGL
LAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVL
YTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVL
FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTI
VIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=36.4028776978417, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=35.3623188405797, Blast_Score=394, Evalue=1e-109,
Organism=Escherichia coli, GI1790167, Length=627, Percent_Identity=43.859649122807, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=29.3103448275862, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532899, Length=441, Percent_Identity=36.9614512471655, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17539970, Length=441, Percent_Identity=36.9614512471655, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17532897, Length=441, Percent_Identity=36.9614512471655, Blast_Score=269, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=438, Percent_Identity=35.8447488584475, Blast_Score=249, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6323731, Length=444, Percent_Identity=28.3783783783784, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323730, Length=235, Percent_Identity=33.1914893617021, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=35.5907780979827, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_MYCBO (P0A589)

Other databases:

- EMBL:   BX248346
- RefSeq:   NP_857106.1
- ProteinModelPortal:   P0A589
- SMR:   P0A589
- EnsemblBacteria:   EBMYCT00000014757
- GeneID:   1091058
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3466c
- GeneTree:   EBGT00050000016850
- HOGENOM:   HBG645312
- OMA:   ITIVIAE
- ProtClustDB:   PRK00331
- BioCyc:   MBOV233413:MB3466C-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67573; Mature: 67573

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 619-619

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAE
CCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCEEEEECCEEEEEHHCCCCCCHHHHHHH
MPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAG
CCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHC
VEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAA
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEE
RRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQA
CCCCCEEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCCCCC
GRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQE
CCCCCCEEEECCHHHHCCCCCEEHHHHHHHHCCHHHHHHHHHHHHCCEEEEEHHHCCHHH
LREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQ
HHHHHHEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCEEEEEEEC
SGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQI
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHCEEEEECCCCCCCCCHHHHHHHHH
AANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEE
FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSAT
EEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHH
LHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASVARARGYDVDKPRNLAKSVTVE
HHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAE
CCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCEEEEECCEEEEEHHCCCCCCHHHHHHH
MPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAG
CCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHC
VEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAA
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEE
RRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQA
CCCCCEEEEECCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCCCCC
GRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQE
CCCCCCEEEECCHHHHCCCCCEEHHHHHHHHCCHHHHHHHHHHHHCCEEEEEHHHCCHHH
LREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQ
HHHHHHEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCEEEEEEEC
SGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQI
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHCEEEEECCCCCCCCCHHHHHHHHH
AANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEE
FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSAT
EEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHH
LHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASVARARGYDVDKPRNLAKSVTVE
HHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972