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The map label for this gene is moaX [H]

Identifier: 148663187

GI number: 148663187

Start: 3719890

End: 3720555

Strand: Reverse

Name: moaX [H]

Synonym: MRA_3365

Alternate gene names: 148663187

Gene position: 3720555-3719890 (Counterclockwise)

Preceding gene: 148663188

Following gene: 148663186

Centisome position: 84.18

GC content: 59.16

Gene sequence:

>666_bases
ATGATTACTGTCAATGTGCTCTACTTTGGCGCGGTTCGCGAAGCGTGCAAGGTCGCTCACGAGAAGATCTCACTCGAAAG
CGGCACCACCGTCGACGGCTTAGTCGACCAATTGCAAATCGACTATCCGCCACTTGCTGATTTTCGCAAGCGAGTGCGGA
TGGCCGTTAACGAATCCATAGCGCCAGCATCAACGATTCTCGACGATGGCGACACGGTGGCGTTCATACCGCAGGTTGCC
GGGGGCTCCGATGTCTACTGCCGGCTCACCGATGAGCCGCTGAGCGTCGATGAAGTGCTCAACGCGATATCTGGACCTTC
CCAGGGCGGCGCCGTCATCTTCGTGGGTACCGTGCGTAACAACAACAACGGCCACGAAGTGACCAAGTTGTACTACGAGG
CCTATCCGGCCATGGTGCACCGCACGCTGATGGACATCATCGAAGAGTGTGAACGACAGGCCGACGGTGTGCGAGTTGCC
GTGGCACACCGGACCGGTGAATTGCGCATCGGTGATGCGGCGGTTGTCATCGGTGCTTCGGCTCCTCACCGCGCGGCCGC
GTTCGACGCCGCTCGCATGTGCATCGAGCGGCTCAAACAGGATGTGCCGATATGGAAGAAGGAGTTCGCACTCGACGGTG
TTGAGTGGGTGGCCAATCGGCCATGA

Upstream 100 bases:

>100_bases
CAGATTGGACGAAAAAAGCGGTGGCCGATCGGGTCATTACCGGCGGCACGACGCGGACGTCAAACCCAGCGATGGTGGCT
CCACCGAGGATGGATGTTGA

Downstream 100 bases:

>100_bases
GCGTGCAGACGGATCCGGCGCTGCGGGAGCACCCCAACCGCGTCGACTGGAACGCGCGATACGAACGCGCGGGTTCGGCG
CACGCGCCGTTTGCCCCGGT

Product: MoaD-MoaE fusion protein MoaX

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 1; Molybdopterin-converting factor large subunit 1; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVA
GGSDVYCRLTDEPLSVDEVLNAISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVA
VAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP

Sequences:

>Translated_221_residues
MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVA
GGSDVYCRLTDEPLSVDEVLNAISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVA
VAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP
>Mature_221_residues
MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVA
GGSDVYCRLTDEPLSVDEVLNAISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVA
VAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=132, Percent_Identity=38.6363636363636, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1787003, Length=130, Percent_Identity=38.4615384615385, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17509279, Length=141, Percent_Identity=36.1702127659575, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356259, Length=139, Percent_Identity=33.8129496402878, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 24051; Mature: 24051

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRKRVRMAVNESI
CEEEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
APASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVLNAISGPSQGGAVIFVGTVRN
CCHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEEEEC
NNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVAVAHRTGELRIGDAAVVIGAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCEEEEEECC
APHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRKRVRMAVNESI
CEEEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
APASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVLNAISGPSQGGAVIFVGTVRN
CCHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEEEEC
NNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVAVAHRTGELRIGDAAVVIGAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCEEEEEECC
APHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]