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The map label for this gene is devR

Identifier: 148662987

GI number: 148662987

Start: 3511418

End: 3512071

Strand: Reverse

Name: devR

Synonym: MRA_3165

Alternate gene names: 148662987

Gene position: 3512071-3511418 (Counterclockwise)

Preceding gene: 148662988

Following gene: 148662986

Centisome position: 79.46

GC content: 63.15

Gene sequence:

>654_bases
GTGGTAAAGGTCTTCTTGGTCGATGACCACGAGGTGGTGCGTCGTGGTCTGGTTGACTTGCTTGGGGCCGATCCCGAGCT
TGACGTCGTAGGTGAGGCGGGTTCGGTCGCCGAGGCGATGGCCAGGGTTCCTGCCGCGCGCCCAGATGTCGCGGTGCTGG
ATGTCCGGTTGCCCGATGGCAACGGCATTGAACTGTGCCGCGATCTGTTGTCCCGCATGCCCGATCTGCGCTGTCTGATC
CTCACGTCCTACACCTCTGACGAGGCCATGCTAGATGCGATTCTCGCCGGTGCCAGCGGATATGTCGTCAAAGACATCAA
GGGAATGGAGTTGGCGCGCGCCGTCAAAGATGTGGGCGCTGGACGGTCGCTGCTGGACAATCGGGCCGCGGCCGCGCTGA
TGGCCAAGCTGCGCGGTGCCGCCGAGAAGCAGGACCCGCTATCAGGCCTTACCGACCAGGAGCGGACGCTACTGGGCCTG
CTTAGCGAGGGCCTGACCAACAAGCAGATCGCCGACCGAATGTTCCTAGCCGAAAAGACGGTGAAGAACTACGTGTCGCG
GTTGCTGGCCAAGCTGGGCATGGAACGTCGGACGCAAGCCGCGGTATTCGCGACGGAGTTGAAGCGCTCGCGGCCACCCG
GTGATGGACCATGA

Upstream 100 bases:

>100_bases
CTCCGCGCACGAATTGTGCGGTGCATACCAGCCCGGATGCGCCGTACTTACGGTACGCAGTGCCAACTTGTAGGGAGCGG
ATCTTGGGAGTGGTGCCCTG

Downstream 100 bases:

>100_bases
CAACAGGGGGCCTCGTCGACGAAAACGACGGCGCCGCAATGCGTCCACTGCGTCACACGCTCTCCCAACTACGCCTGCAC
GAGCTGCTGGTCGAGGTGCA

Product: two component transcriptional regulatory protein DevR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLI
LTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGL
LSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP

Sequences:

>Translated_217_residues
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLI
LTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGL
LSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
>Mature_217_residues
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLI
LTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGL
LSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=36.1386138613861, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=33.8308457711443, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788222, Length=195, Percent_Identity=27.1794871794872, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787473, Length=204, Percent_Identity=31.8627450980392, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786747, Length=192, Percent_Identity=25.5208333333333, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=27.0531400966184, Blast_Score=71, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEVR_MYCTU (P95193)

Other databases:

- EMBL:   U22037
- EMBL:   AE000516
- EMBL:   BX842582
- PIR:   F70645
- RefSeq:   NP_217649.1
- RefSeq:   NP_337743.1
- PDB:   1ZLJ
- PDB:   1ZLK
- PDB:   3C3W
- PDB:   3C57
- PDBsum:   1ZLJ
- PDBsum:   1ZLK
- PDBsum:   3C3W
- PDBsum:   3C57
- ProteinModelPortal:   P95193
- SMR:   P95193
- EnsemblBacteria:   EBMYCT00000000635
- EnsemblBacteria:   EBMYCT00000072450
- GeneID:   888842
- GeneID:   923420
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3219
- KEGG:   mtu:Rv3133c
- TIGR:   MT3219
- TubercuList:   Rv3133c
- GeneTree:   EBGT00050000014817
- HOGENOM:   HBG753323
- OMA:   LHCLILT
- ProtClustDB:   CLSK792301
- GO:   GO:0005829
- GO:   GO:0009405
- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.25.40.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00038
- SMART:   SM00421
- SMART:   SM00448

Pfam domain/function: PF00196 GerE; PF00072 Response_reg; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 23294; Mature: 23294

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00622 HTH_LUXR_1; PS50043 HTH_LUXR_2; PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDG
CEEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEEEECCCC
NGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGA
CCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHCC
GRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKT
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDG
CEEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEEEECCCC
NGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGA
CCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHCC
GRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKT
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036