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The map label for this gene is cyp141

Identifier: 148662975

GI number: 148662975

Start: 3498665

End: 3499867

Strand: Direct

Name: cyp141

Synonym: MRA_3153

Alternate gene names: 148662975

Gene position: 3498665-3499867 (Clockwise)

Preceding gene: 148662974

Following gene: 148662976

Centisome position: 79.16

GC content: 59.68

Gene sequence:

>1203_bases
ATGACAAGCACCTCGATTCCGACGTTCCCGTTCGACCGGCCGGTCCCGACGGAGCCGTCCCCAATGCTGTCGGAACTGAG
AAACAGCTGTCCGGTAGCCCCGATAGAGTTGCCCTCGGGGCACACAGCATGGCTCGTCACTCGCTTTGACGATGTAAAGG
GAGTGCTGTCCGACAAGCGTTTCAGCTGCAGGGCGGCAGCGCACCCGTCGTCGCCCCCGTTCGTGCCGTTCGTGCAGCTT
TGCCCCAGCTTGTTGAGCATCGATGGGCCCCAACACACCGCGGCCCGCCGTCTGCTCGCGCAGGGCCTAAATCCCGGCTT
CATCGCACGCATGCGGCCCGTTGTCCAACAGATCGTCGACAATGCGCTCGACGATCTGGCAGCCGCGGAACCACCGGTGG
ACTTCCAGGAAATAGTAAGTGTCCCTATCGGAGAACAGCTCATGGCCAAGCTACTCGGGGTCGAGCCCAAAACCGTGCAC
GAGCTCGCGGCGCACGTGGATGCGGCGATGTCCGTGTGTGAGATCGGCGACGAGGAGGTGAGCCGGCGGTGGTCAGCACT
GTGCACGATGGTCATCGACATACTGCACCGCAAGCTCGCCGAACCGGGTGATGACCTACTTAGCACGATCGCCCAGGCGA
ACCGGCAACAGTCCACCATGACCGACGAGCAGGTTGTCGGCATGCTCCTCACCGTCGTGATCGGAGGAGTCGACACACCG
ATCGCCGTGATCACAAACGGGCTGGCGAGCCTGCTGCACCACCGCGATCAATATGAACGGCTCGTTGAAGACCCAGGCCG
TGTCGCTCGTGCGGTTGAAGAAATAGTCCGGTTTAATCCGGCAACTGAAATTGAGCACTTGCGAGTTGTCACCGAGGATG
TCGTCATTGCCGGAACCGCGCTATCGGCGGGGAGCCCAGCATTTACCTCTATCACTTCGGCTAACCGCGACTCCGACCAA
TTCCTGGACCCCGATGAGTTTGATGTCGAACGTAATCCGAACGAACACATAGCATTTGGATATGGTCCACATGCTTGCCC
GGCCTCAGCGTATTCACGCATGTGCTTGACGACGTTCTTCACCTCGCTTACCCAGCGATTTCCGCAACTTCAACTCGCAA
GACCGTTTGAGGATTTGGAACGACGGGGTAAGGGCCTACATTCGGTGGGGATCAAGGAACTCCTTGTTACCTGGCCGACG
TGA

Upstream 100 bases:

>100_bases
TCCCGTTTGAGGATCTCGCCCCAGGGCGATGGGTTGGCGGGATGTCGATGTACCCGGAAGAGCAAAACGTGGCATGCGAT
AACGATCCGAGAGGAGTGCG

Downstream 100 bases:

>100_bases
CCCCGCGTGCCAGCAAGGGACTGTTGACTTCTCCGACGGATGAAAGCCGCCCTGGAATATCCAACCGCTCCTGCTCCTCG
GTCAACTCAAGCCGAAACCG

Product: putative cytochrome p450 141 CYP141

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQL
CPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH
ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP
IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQ
FLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT

Sequences:

>Translated_400_residues
MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQL
CPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH
ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP
IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQ
FLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
>Mature_399_residues
TSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLC
PSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHE
LAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPI
AVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQF
LDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CP141_MYCTU (O08362)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   H70921
- RefSeq:   NP_217637.1
- RefSeq:   NP_337729.1
- ProteinModelPortal:   O08362
- SMR:   O08362
- EnsemblBacteria:   EBMYCT00000002001
- EnsemblBacteria:   EBMYCT00000072120
- GeneID:   887409
- GeneID:   923483
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3203
- KEGG:   mtu:Rv3121
- TIGR:   MT3203
- TubercuList:   Rv3121
- GeneTree:   EBGT00050000015568
- HOGENOM:   HBG131184
- OMA:   IPHRNAV
- ProtClustDB:   CLSK792294
- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972
- Gene3D:   G3DSA:1.10.630.10
- PANTHER:   PTHR19383
- PRINTS:   PR00359

Pfam domain/function: PF00067 p450; SSF48264 Cytochrome_P450

EC number: NA

Molecular weight: Translated: 43731; Mature: 43600

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2073c7e4)-; HASH(0x1f9608f8)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCEEEEEEHHHHHHHHHCCC
FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV
HHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHH
SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCH
IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECC
LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHH
TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
HHHHHHCCCCHHCCCHHHHHHHCCCCHHHHHHHHHHCCCH
>Mature Secondary Structure 
TSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKR
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCEEEEEEHHHHHHHHHCCC
FSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVD
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEV
HHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHH
SRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCH
IAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECC
LSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFF
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHH
TSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
HHHHHHCCCCHHCCCHHHHHHHCCCCHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036