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The map label for this gene is 148662451

Identifier: 148662451

GI number: 148662451

Start: 2950980

End: 2951930

Strand: Reverse

Name: 148662451

Synonym: MRA_2639

Alternate gene names: NA

Gene position: 2951930-2950980 (Counterclockwise)

Preceding gene: 148662452

Following gene: 148662450

Centisome position: 66.79

GC content: 67.93

Gene sequence:

>951_bases
GTGATTGCCGGCCTTAAGGGCTTGAAGCTGCCCAAAGATCCGCGCAGTTCCGTGACGCGCACCGCGACCGACTGGGCGTA
TGCGGCCGGCTGGATGGCCGTACGGGCGCTGCCAGAGTTCGCCGTACGCAACGCATTCGACACCGGAGCGCGCTACTTTG
CCCGCCACGGCGGGCCCGAGCAGCTGCGCAAGAACCTGGCCCGCGTCCTGGGTGTGCCGCCAGCCGCGGTGCCGGACCCG
CTGATGTGCGCCTCGCTGGAGTCCTACGGGCGCTACTGGCGTGAGGTGTTCCGGCTGCCGACGATAAACCACCGCAAGCT
GGCCCGCCAGCTCGACCGCGTGATCGGTGGACTGGATCACCTGGACGCGGCGCTGGCCGCGGGCCTCGGTGCCGTGCTGG
CGTTGCCGCACAGCGGCAACTGGGATATGGCCGGGATGTGGCTGGTGCAGCGGCACGGCACCTTCACCACCGTCGCCGAG
CGCCTAAAACCCGAATCGCTGTACCAGCGCTTTATCGACTACCGCGAAAGCCTGGGATTTGAGGTGCTGCCGCTGTCCGG
CGGCGAACGGCCGCCGTTCGAGGTGCTCTCTGAGCGGCTGAGGAACAACCGAGTGGTCTGCCTGATGGCCGAGCGCGATC
TCACCCGCACCGGTGTTGAGGTCGACTTCTTCGGCGAGCCCACCCGGATGCCGGTGGGGCCGGCGAAGCTGGCGGTCGAG
ACCGGTGCGGCATTGCTGCCCACACATTGCTGGTTCGAGGGCCGCGGCTGGGGTTTCCAGGTGTATCCGGCGCTGGATTG
CACCAGCGGTGACGTCGCTGCCATCACACAGGCGCTGGCCGACCGCTTCGCGCAGAACATTGCCGCCCATCCCGCGGATT
GGCACATGCTGCAGCCCCAGTGGCTGGCCGACTTATCCGAATCGCGGCGGGCGCAACTGAGGTCCAGATGA

Upstream 100 bases:

>100_bases
TGGCCGTCGCCAGCGTGATCACCTGCGTGCAGCGGTTGCACACGGTCTGGACTTCACCCGGAGCCATCGATCGGATGGCG
ATTCCTGGAAAGGGCGACCG

Downstream 100 bases:

>100_bases
GGAAAGCCTGATGCGGATCGGCATGATTTGTCCGTACTCGTTCGACGTCCCGGGCGGGGTGCAGTCGCATGTGCTACAGC
TTGCCGAGGTGATGCGCACC

Product: lipid A biosynthesis lauroyl acyltransferase

Products: NA

Alternate protein names: PIM acyltransferase

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDP
LMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAE
RLKPESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVE
TGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR

Sequences:

>Translated_316_residues
MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDP
LMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAE
RLKPESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVE
TGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR
>Mature_316_residues
MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDP
LMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAE
RLKPESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVE
TGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR

Specific function: Catalyzes the acylation to the position 6 of the alpha- 1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1)

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACYLT_MYCTU (O06203)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   B70571
- RefSeq:   NP_217127.1
- RefSeq:   NP_337188.1
- EnsemblBacteria:   EBMYCT00000002406
- EnsemblBacteria:   EBMYCT00000072533
- GeneID:   888618
- GeneID:   925621
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2686
- KEGG:   mtu:Rv2611c
- TIGR:   MT2686
- TubercuList:   Rv2611c
- GeneTree:   EBGT00050000017147
- HOGENOM:   HBG430965
- OMA:   DWHMLQR
- ProtClustDB:   PRK07920
- GO:   GO:0040007
- InterPro:   IPR004960

Pfam domain/function: PF03279 Lip_A_acyltrans

EC number: 2.3.1.-

Molecular weight: Translated: 35127; Mature: 35127

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20208704)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QLRKNLARVLGVPPAAVPDPLMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDH
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
LDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAERLKPESLYQRFIDYRESLGF
HHHHHHHCCHHEEECCCCCCCCHHHEEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCC
EVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVE
EEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHCCCEEEECCCCCCCCCCHHHHHHH
TGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQ
CCCHHCCCCCEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
WLADLSESRRAQLRSR
HHHHHHHHHHHHHCCH
>Mature Secondary Structure
MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QLRKNLARVLGVPPAAVPDPLMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDH
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
LDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAERLKPESLYQRFIDYRESLGF
HHHHHHHCCHHEEECCCCCCCCHHHEEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCC
EVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVE
EEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHCCCEEEECCCCCCCCCCHHHHHHH
TGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQ
CCCHHCCCCCEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
WLADLSESRRAQLRSR
HHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036