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The map label for this gene is PE_PGRS35

Identifier: 148661793

GI number: 148661793

Start: 2236144

End: 2237820

Strand: Direct

Name: PE_PGRS35

Synonym: MRA_1995

Alternate gene names: 148661793

Gene position: 2236144-2237820 (Clockwise)

Preceding gene: 148661787

Following gene: 148661795

Centisome position: 50.59

GC content: 64.88

Gene sequence:

>1677_bases
GTGTCATTTCTGGTCGTGGTTCCCGAGTTCTTGACGTCCGCGGCAGCGGATGTGGAGAACATAGGTTCCACACTGCGCGC
GGCGAATGCCGCGGCTGCCGCCTCGACCACCGCGCTTGCGGCCGCTGGCGCTGATGAGGTATCGGCGGCGGTGGCAGCGC
TGTTTGCCAGGTTCGGTCAGGAATATCAAGCGGTCAGCGCGCAGGCGAGCGCTTTCCATCAACAGTTCGTGCAGACGCTG
AACTCGGCGTCAGGATCGTATGCGGCCGCGGAGGCCACCATCGCGTCACAGTTGCAGACCGCGCAGCACGATCTGCTGGG
CGCGGTCAATGCACCAACCGAAACGTTGTTGGGGCGTCCGCTAATCGGCGACGGAGCACCCGGGACGGCAACGAGTCCGA
ATGGCGGGGCGGGTGGGCTGCTGTACGGCAACGGCGGCAACGGTTATTCCGCGACGGCGTCGGGGGTCGGCGGCGGGGCC
GGCGGTTCCGCGGGGTTGATCGGCAATGGCGGCGCCGGGGGAGCCGGCGGACCCAACGCCCCCGGGGGAGCCGGCGGCAA
CGGTGGCTGGCTGCTCGGCAACGGCGGGATCGGCGGGCCCGGGGGCGCGTCGAGCATCCCCGGCATGAGTGGTGGAGCCG
GCGGAACCGGCGGTGCCGCAGGACTTTTGGGCTGGGGAGCGAACGGCGGAGCCGGCGGCCTCGGTGATGGAGTCGGTGTC
GATCGTGGCACGGGCGGCGCCGGAGGCCGCGGCGGCCTGTTGTATGGCGGATACGGCGTCAGTGGGCCAGGCGGCGACGG
CAGAACCGTCCCGCTGGAGATAATTCATGTCACAGAGCCGACGGTACATGCCAACGTCAACGGCGGACCGACGTCAACCA
TTCTGGTCGACACCGGATCCGCTGGTCTTGTTGTCTCGCCTGAGGATGTCGGGGGAATCCTGGGAGTGCTTCACATGGGC
CTCCCAACCGGATTGAGCATCAGCGGTTACAGCGGGGGGCTGTACTACATCTTCGCCACGTATACCACGACGGTGGACTT
CGGGAATGGCATCGTCACCGCGCCGACCGCCGTTAATGTCGTCCTCTTGTCCATCCCAACGTCCCCCTTCGCCATTTCGA
CCTACTTCAGCGCCTTGCTGGCCGATCCGACAACAACTCCGTTCGAAGCCTATTTCGGTGCCGTCGGCGTGGACGGCGTT
CTGGGAGTTGGGCCCAATGCGGTGGGACCAGGCCCCAGCATTCCGACGATGGCGTTACCGGGTGACCTCAACCAGGGAGT
GCTCATCGACGCACCCGCAGGTGAGCTCGTGTTCGGTCCCAACCCGCTACCTGCGCCCAACGTCGAGGTCGTCGGATCGC
CGATCACCACCCTGTACGTAAAGATCGATGGTGGGACTCCCATACCCGTCCCCTCGATCATCGATTCCGGTGGGGTAACG
GGAACCATCCCGTCATATGTCATCGGATCCGGAACCCTGCCGGCGAACACAAACATTGAGGTCTACACCAGCCCCGGCGG
TGATCGGCTCTACGCGTTCAACACAAACGATTACCGCCCGACCGTCATTTCATCCGGCCTGATGAATACCGGGTTCTTGC
CCTTCAGATTCCAGCCGGTGTACATCGACTACAGCCCCAGCGGTATAGGGACAACAGTCTTTGATCATCCGGCGTGA

Upstream 100 bases:

>100_bases
TGCTGTGCCGTGCGGTAGCTACTGAAAATCCGAGATGTCAAAGGCAGCGTCTGGATACGCTGTATGCGCGCAGGGATGGT
GATCGAGGCGGAGGGGCGGC

Downstream 100 bases:

>100_bases
TCGAGCCTGTTCGCCGCGAATGTCGCCGCCTGGCTTGTCATCCCCGACTGAACATACGAAACATGCGCCATAATATTGCC
GCCTCCGGTGCATATTGGAT

Product: PE-PGRS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGADEVSAAVAALFARFGQEYQAVSAQASAFHQQFVQTL
NSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGA
GGSAGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGAAGLLGWGANGGAGGLGDGVGV
DRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPTVHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMG
LPTGLSISGYSGGLYYIFATYTTTVDFGNGIVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDGV
LGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVT
GTIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA

Sequences:

>Translated_558_residues
MSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGADEVSAAVAALFARFGQEYQAVSAQASAFHQQFVQTL
NSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGA
GGSAGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGAAGLLGWGANGGAGGLGDGVGV
DRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPTVHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMG
LPTGLSISGYSGGLYYIFATYTTTVDFGNGIVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDGV
LGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVT
GTIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA
>Mature_557_residues
SFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGADEVSAAVAALFARFGQEYQAVSAQASAFHQQFVQTLN
SASGSYAAAEATIASQLQTAQHDLLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGAG
GSAGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGAAGLLGWGANGGAGGLGDGVGVD
RGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPTVHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGL
PTGLSISGYSGGLYYIFATYTTTVDFGNGIVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDGVL
GVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVTG
TIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PE family. PGRS subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PG35_MYCTU (Q10873)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   E70756
- RefSeq:   NP_336497.1
- RefSeq:   YP_177854.1
- ProteinModelPortal:   Q10873
- EnsemblBacteria:   EBMYCT00000000604
- EnsemblBacteria:   EBMYCT00000070740
- GeneID:   885921
- GeneID:   924380
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2036
- KEGG:   mtu:Rv1983
- TIGR:   MT2036
- TubercuList:   Rv1983
- GeneTree:   EBGT00070000031715
- HOGENOM:   HBG569197
- OMA:   NSSAGSY
- ProtClustDB:   CLSK799857
- InterPro:   IPR000084

Pfam domain/function: PF00934 PE

EC number: NA

Molecular weight: Translated: 53738; Mature: 53607

Theoretical pI: Translated: 3.97; Mature: 3.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ed1932c)-; HASH(0x1eef5eb4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGADEVSAAVAALFARFGQ
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCH
EYQAVSAQASAFHQQFVQTLNSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETLLGRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
LIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGAGGSAGLIGNGGAGGAGGPNA
CCCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCC
PGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGAAGLLGWGANGGAGGLGDGVGV
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPTVHANVNGGPTSTILVDTGS
CCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCCEEEEEECCC
AGLVVSPEDVGGILGVLHMGLPTGLSISGYSGGLYYIFATYTTTVDFGNGIVTAPTAVNV
CCEEECCHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEEEEEEEEECCCCEEECCCEEEE
VLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDGVLGVGPNAVGPGPSIPTMALP
EEEEECCCCEEHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCCCCCCEECC
GDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVT
CCCCCCEEEECCCCCEEECCCCCCCCCCEEECCCEEEEEEEECCCCCCCCCHHHCCCCCC
GTIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQPV
CCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCCHHEECCCCCCCCCCEEEEEE
YIDYSPSGIGTTVFDHPA
EEEECCCCCCCCCCCCCH
>Mature Secondary Structure 
SFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGADEVSAAVAALFARFGQ
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCH
EYQAVSAQASAFHQQFVQTLNSASGSYAAAEATIASQLQTAQHDLLGAVNAPTETLLGRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
LIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGAGGSAGLIGNGGAGGAGGPNA
CCCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCC
PGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGGAAGLLGWGANGGAGGLGDGVGV
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIHVTEPTVHANVNGGPTSTILVDTGS
CCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCCEEEEEECCC
AGLVVSPEDVGGILGVLHMGLPTGLSISGYSGGLYYIFATYTTTVDFGNGIVTAPTAVNV
CCEEECCHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEEEEEEEEECCCCEEECCCEEEE
VLLSIPTSPFAISTYFSALLADPTTTPFEAYFGAVGVDGVLGVGPNAVGPGPSIPTMALP
EEEEECCCCEEHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCCCCCCEECC
GDLNQGVLIDAPAGELVFGPNPLPAPNVEVVGSPITTLYVKIDGGTPIPVPSIIDSGGVT
CCCCCCEEEECCCCCEEECCCCCCCCCCEEECCCEEEEEEEECCCCCCCCCHHHCCCCCC
GTIPSYVIGSGTLPANTNIEVYTSPGGDRLYAFNTNDYRPTVISSGLMNTGFLPFRFQPV
CCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCCHHEECCCCCCCCCCEEEEEE
YIDYSPSGIGTTVFDHPA
EEEECCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036