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The map label for this gene is pgsA2

Identifier: 148661628

GI number: 148661628

Start: 2079012

End: 2079641

Strand: Direct

Name: pgsA2

Synonym: MRA_1834

Alternate gene names: 148661628

Gene position: 2079012-2079641 (Clockwise)

Preceding gene: 148661627

Following gene: 148661629

Centisome position: 47.04

GC content: 60.32

Gene sequence:

>630_bases
ATGGAGCCGGTGCTCACGCAGAATCGGGTGCTGACTGTCCCCAACATGTTGAGCGTTATTCGCCTCGCGCTCATCCCAGC
ATTCGTCTACGTCGTGCTCAGCGCGCACGCCAATGGCTGGGGGGTAGCGATCCTGGTGTTCAGTGGCGTTTCGGACTGGG
CTGATGGCAAGATTGCACGGCTACTAAACCAGTCATCGCGGCTGGGCGCGCTGCTGGACCCGGCCGTTGATCGCCTCTAC
ATGGTCACTGTTCCTATCGTGTTTGGCCTGAGCGGCATCGTGCCGTGGTGGTTTGTCCTTACGTTGCTGACCCGCGATGC
GCTGCTGGCTGGGACGCTGCCGCTGCTATGGAGCCGTGGACTGTCAGCGCTACCGGTGACCTACGTCGGTAAGGCAGCGA
CTTTCGGCTTCATGGTTGGCTTTCCGACCATTCTGTTGGGGCAATGCGATCCATTGTGGAGCCATGTGCTGCTGGCCTGT
GGTTGGGCATTCTTGATCTGGGGTATGTATGCCTACTTGTGGGCCTTCGTGCTGTATGCAGTGCAGATGACGATGGTGGT
GCGGCAGATGCCTAAGCTCAAGGGCAGGGCTCATCGGCCGGCGGCCCAGAACGCTGGTGAACGTGGCTGA

Upstream 100 bases:

>100_bases
CCGCCGTTTCGGCGCGCATCGTCGCCAGGCTAGATCCGATTGCCCGGCTCCTCAGCCCGCCGTTTCGGCGCGCATCGTCG
CCAGGCTAAGGTCACGGCTC

Downstream 100 bases:

>100_bases
GTCTGACCGGCTGCTCGGCGGCTACGACCCCAACGCCGGCTACAGCGCCCACGCAGGGGCGCAGCCACAACGCATCCCGG
TTCCGTCGTTGCTGCGCGCG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAILVFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLY
MVTVPIVFGLSGIVPWWFVLTLLTRDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLAC
GWAFLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG

Sequences:

>Translated_209_residues
MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAILVFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLY
MVTVPIVFGLSGIVPWWFVLTLLTRDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLAC
GWAFLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG
>Mature_209_residues
MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAILVFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLY
MVTVPIVFGLSGIVPWWFVLTLLTRDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLAC
GWAFLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

Organism=Escherichia coli, GI1788220, Length=141, Percent_Identity=31.9148936170213, Blast_Score=64, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24650130, Length=106, Percent_Identity=33.9622641509434, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650126, Length=106, Percent_Identity=33.9622641509434, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650128, Length=106, Percent_Identity=33.9622641509434, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA1_MYCTU (P63753)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   G70720
- RefSeq:   NP_216338.1
- RefSeq:   NP_336329.1
- EnsemblBacteria:   EBMYCT00000003265
- EnsemblBacteria:   EBMYCT00000071634
- GeneID:   885126
- GeneID:   923624
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1870
- KEGG:   mtu:Rv1822
- TIGR:   MT1870
- TubercuList:   Rv1822
- GeneTree:   EBGT00050000016087
- HOGENOM:   HBG686655
- OMA:   WLDGKLA
- ProtClustDB:   CLSK791412
- BRENDA:   2.7.8.5
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 22912; Mature: 22912

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1b2ebd40)-; HASH(0x1edbf610)-; HASH(0x1eed79cc)-; HASH(0x1ee2c2b8)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAILVFSGVSDWADGKIAR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHH
LLNQSSRLGALLDPAVDRLYMVTVPIVFGLSGIVPWWFVLTLLTRDALLAGTLPLLWSRG
HHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLACGWAFLIWGMYAYLWAFVLYA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMTMVVRQMPKLKGRAHRPAAQNAGERG
HHHHHHHHHHHHHCCCCCCCHHCCCCCCH
>Mature Secondary Structure
MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAILVFSGVSDWADGKIAR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHH
LLNQSSRLGALLDPAVDRLYMVTVPIVFGLSGIVPWWFVLTLLTRDALLAGTLPLLWSRG
HHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLACGWAFLIWGMYAYLWAFVLYA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMTMVVRQMPKLKGRAHRPAAQNAGERG
HHHHHHHHHHHHHCCCCCCCHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036