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The map label for this gene is mmpL6

Identifier: 148661353

GI number: 148661353

Start: 1763261

End: 1764454

Strand: Direct

Name: mmpL6

Synonym: MRA_1569

Alternate gene names: 148661353

Gene position: 1763261-1764454 (Clockwise)

Preceding gene: 148661352

Following gene: 148661354

Centisome position: 39.89

GC content: 61.64

Gene sequence:

>1194_bases
GTGCAGGGGATTTCAGTGACTGGCCTGGTCAAACGCGGCTGGATGGTGAGATCCGTCTTTGACACGATCGACGGTATCGA
CCAACTCGGCGAGCAGCTGGCCAGCGTGACCGTAACCTTGGACAAGTTGGCTGCGATCCAGCCTCAATTGGTGGCGCTGC
TACCAGACGAGATCGCCAGCCAGCAGATCAATCGGGAACTGGCGCTGGCTAACTACGCCACCATGTCCGGGATCTATGCC
CAGACGGCGGCCTTGATCGAAAACGCTGCCGCCATGGGACAAGCCTTTGACGCCGCCAAGAACGACGACTCCTTCTATCT
GCCGCCGGAGGCTTTTGACAACCCAGATTTCCAGCGCGGCCTGAAATTGTTCCTGTCGGCAGACGGTAAGGCGGCTCGGA
TGATCATCTCCCATGAAGGCGATCCCGCCACCCCCGAAGGCATTTCGCATATCGACGCGATCAAGCAGGCGGCCCACGAG
GCCGTGAAGGGCACTCCCATGGCGGGTGCTGGGATCTATCTGGCCGGCACGGCCGCCACCTTCAAGGACATTCAAGACGG
CGCCACCTACGACCTCCTGATCGCCGGAATAGCCGCGCTGAGCTTGATTTTGCTCATCATGATGATCATTACCCGAAGCC
TGGTTGCGGCGCTGGTGATCGTGGGCACGGTGGCGCTGTCGTTGGGCGCTTCTTTTGGCCTGTCCGTGCTGGTGTGGCAG
CATCTTCTCGGTATCCAGTTGTACTGGATCGTGCTCGCGCTGGCCGTCATCCTGCTCCTGGCCGTGGGATCGGACTATAA
CTTGCTGCTGATTTCCCGATTCAAGGAGGAGATCGGTGCAGGTTTGAACACCGGCATCATCCGTGCGATGGCCGGCACCG
GCGGGGTGGTGACCGCTGCCGGCCTGGTGTTCGCCGCCACTATGTCTTCGTTCGTGTTCAGTGATTTGCGGGTCCTCGGT
CAGATCGGGACCACCATTGGTCTTGGGCTGCTGTTCGACACGCTGGTGGTGCGCGCGTTCATGACCCCGTCCATCGCGGT
GCTGCTCGGGCGCTGGTTCTGGTGGCCGCAACGAGTGCGCCCGCGCCCTGCCAGCAGGATGCTTCGGCCGTACGGCCCGC
GGCCCGTGGTTCGTGAATTGCTGCTGCGCGAGGGCAACGATGACCCGAGAACTCAGGTGGCTACCCACCGTTAA

Upstream 100 bases:

>100_bases
GGTCCCGTACCGTACTGTTGAATCCGCGGATCCCCGCCTGAGGTACGGGGCGTGGTCGCGCCCCGGGCAATAGCGTCGCC
GGTTATCGAAAGGCTAACGG

Downstream 100 bases:

>100_bases
GGTGGTGGGATGCCGCTTTCAGGGGAATATGCGCCGAGCCCGCTCGACTGGTCGCGCGAGCAAGCCGACACGTATATGAA
GTCCGGCGGAACCGAGGGCA

Product: transmembrane transport protein MmpL6

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIASQQINRELALANYATMSGIYA
QTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHE
AVKGTPMAGAGIYLAGTAATFKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQ
HLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLG
QIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR

Sequences:

>Translated_397_residues
MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIASQQINRELALANYATMSGIYA
QTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHE
AVKGTPMAGAGIYLAGTAATFKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQ
HLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLG
QIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR
>Mature_397_residues
MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIASQQINRELALANYATMSGIYA
QTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHE
AVKGTPMAGAGIYLAGTAATFKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQ
HLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLG
QIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mmpL family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MMPL6_MYCTU (Q10773)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   B70763
- RefSeq:   NP_216073.1
- RefSeq:   NP_336061.1
- ProteinModelPortal:   Q10773
- EnsemblBacteria:   EBMYCT00000001271
- EnsemblBacteria:   EBMYCT00000069185
- GeneID:   886033
- GeneID:   924338
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1608
- KEGG:   mtu:Rv1557
- TIGR:   MT1608
- TubercuList:   Rv1557
- GeneTree:   EBGT00050000015043
- HOGENOM:   HBG565409
- OMA:   FLWADFA
- ProtClustDB:   CLSK791247
- InterPro:   IPR004869

Pfam domain/function: PF03176 MMPL

EC number: NA

Molecular weight: Translated: 42422; Mature: 42422

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e89c828)-; HASH(0x1e8963c4)-; HASH(0x1e788928)-; HASH(0x1e87a1d4)-; HASH(0x1d0fa554)-; HASH(0x1c8243e0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIAS
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHH
QQINRELALANYATMSGIYAQTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHH
LKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAAT
HHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHH
FKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHH
GLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCC
PRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR
CCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure
MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIAS
CCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHH
QQINRELALANYATMSGIYAQTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHH
LKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAAT
HHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHH
FKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHH
GLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCC
PRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR
CCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036