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The map label for this gene is dinX [H]

Identifier: 148661333

GI number: 148661333

Start: 1741373

End: 1742764

Strand: Direct

Name: dinX [H]

Synonym: MRA_1549

Alternate gene names: 148661333

Gene position: 1741373-1742764 (Clockwise)

Preceding gene: 148661332

Following gene: 148661335

Centisome position: 39.4

GC content: 68.03

Gene sequence:

>1392_bases
GTGCTGCACCTGGACATGGATGCGTTTTTCGCCTCGGTCGAACAGCTCACCCGGCCGACCCTGCGGGGGCGGCCGGTGCT
GGTTGGCGGGCTGGGTGGGCGAGGTGTGGTGGCCGGCGCGAGCTATGAAGCGCGGGCCTACGGTGCCCGATCGGCCATGC
CGATGCATCAGGCCCGCAGGCTGATCGGGGTGACGGCCGTGGTGTTGCCGCCACGCGGGGTGGTGTACGGGATCGCCAGC
CGCCGGGTATTCGACACCGTGCGCGGCCTGGTGCCCGTCGTCGAACAGCTTTCTTTCGATGAAGCGTTCGCCGAACCGCC
CCAACTCGCCGGGGCAGTGGCCGAGGACGTCGAGACGTTCTGCGAACGGTTGCGGCGACGGGTGCGCGACGAGACCGGCC
TGATTGCCTCGGTCGGAGCGGGCTCGGGCAAGCAGATCGCCAAGATTGCTTCTGGTCTGGCCAAACCCGACGGCATTCGG
GTAGTCCGGCACGCTGAAGAGCAAGCGCTTCTCAGCGGATTGCCGGTACGACGGCTGTGGGGCATCGGCCCGGTCGCCGA
GGAAAAGCTGCATCGGCTCGGCATCGAGACGATCGGGCAGCTGGCCGCGCTGAGCGATGCCGAGGCGGCCAACATCCTAG
GCGCGACGATTGGGCCCGCGCTGCACCGGCTGGCCCGTGGCATCGACGACCGCCCAGTGGTGGAGCGCGCCGAAGCCAAG
CAAATCAGCGCCGAGTCCACGTTCGCCGTCGATCTGACCACCATGGAGCAATTGCACGAGGCGATCGACTCCATCGCTGA
GCACGCGCACCAACGCCTGCTGCGCGACGGCCGCGGCGCCCGCACCATCACGGTGAAGCTAAAGAAATCCGACATGAGCA
CGCTAACCCGCTCGGCGACGATGCCCTACCCGACGACCGACGCCGGCGCGCTGTTTACGGTGGCCCGCCGGCTGCTGCCG
GATCCACTGCAAATCGGGCCAATTCGTCTTCTGGGTGTTGGGTTTTCGGGTTTGAGCGACATTCGCCAGGAGTCGTTGTT
TGCCGACTCGGACTTGACGCAGGAAACGGCGGCAGCGCATTACGTCGAAACACCGGGAGCGGTCGTGCCGGCCGCGCACG
ACGCCACGATGTGGCGGGTCGGCGATGACGTCGCCCACCCTGAGCTTGGGCACGGCTGGGTGCAGGGAGCGGGCCACGGC
GTGGTCACCGTGCGGTTCGAAACGCGTGGTTCAGGCCCGGGCTCGGCGCGGACGTTCCCCGTCGACACCGGCGACATCAG
CAACGCCAGCCCGCTTGACAGCTTGGACTGGCCGGACTACATCGGCCAGCTATCGGTCGAGGGGTCCGCCGGCGCCTCAG
CCCCAACGGTCGATGACGTCGGCGACCGGTGA

Upstream 100 bases:

>100_bases
CCACGTCGGCCAAGGCCGATGGCAGCGGCTGAGGTTGATCGCCATAGCGAAAACTAGCTCGGTAGCCCCAAATAGCATCA
CGGGTGTGGAGTCCCGCTGG

Downstream 100 bases:

>100_bases
GTTGGCCGCCAGCGCGGCCATTAGCAGCACCCGGGCCTGGGACGGCGGCAGTCGCGGTACCATCACCGCGCCAGCCTCCA
CCAGGTCGTGCCCGGGACCA

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV 1 [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIAS
RRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIR
VVRHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAK
QISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLP
DPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHG
VVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR

Sequences:

>Translated_463_residues
MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIAS
RRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIR
VVRHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAK
QISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLP
DPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHG
VVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
>Mature_463_residues
MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIAS
RRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIR
VVRHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAK
QISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLP
DPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHG
VVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=339, Percent_Identity=27.4336283185841, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7706681, Length=340, Percent_Identity=27.3529411764706, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI7705344, Length=259, Percent_Identity=26.6409266409266, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI5729982, Length=193, Percent_Identity=29.5336787564767, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1786425, Length=327, Percent_Identity=31.4984709480122, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787432, Length=370, Percent_Identity=29.1891891891892, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193205700, Length=408, Percent_Identity=27.9411764705882, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537959, Length=319, Percent_Identity=25.3918495297806, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193205702, Length=226, Percent_Identity=31.858407079646, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324921, Length=387, Percent_Identity=21.7054263565891, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19923006, Length=414, Percent_Identity=27.0531400966184, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21355641, Length=326, Percent_Identity=23.9263803680982, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644984, Length=326, Percent_Identity=23.9263803680982, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 49108; Mature: 49108

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARR
CEECCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCHHHCCCCCCCCHHHHHH
LIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETF
HHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
CERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLW
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHH
GIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAK
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSAT
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCC
MPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAH
CCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHH
YVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFP
HCCCCCCEECCCCCCEEEECCCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCCCCEEC
VDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
CCCCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARR
CEECCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCHHHCCCCCCCCHHHHHH
LIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETF
HHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
CERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLW
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHH
GIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAK
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSAT
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCC
MPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAH
CCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHH
YVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFP
HCCCCCCEECCCCCCEEEECCCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCCCCEEC
VDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR
CCCCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]