Click here to switch to the map view.

The map label for this gene is ctaB [H]

Identifier: 148661243

GI number: 148661243

Start: 1636546

End: 1637472

Strand: Direct

Name: ctaB [H]

Synonym: MRA_1460

Alternate gene names: 148661243

Gene position: 1636546-1637472 (Clockwise)

Preceding gene: 148661235

Following gene: 148661245

Centisome position: 37.03

GC content: 66.13

Gene sequence:

>927_bases
GTGAACGTTCGCGGGCGCGTCGCGCCGCGCCGAGTGACTGGTAGGGCAATGAGCACCCTGCTGGCCTACCTGGCGTTAAC
CAAGCCGCGAGTCATCGAGCTGCTGTTGGTCACCGCGATACCGGCGATGCTGCTGGCCGACCGCGGCGCCATTCATCCGC
TGCTCATGCTCAACACGCTCGTCGGCGGGATGATGGCCGCCGCCGGCGCCAACACGCTCAACTGCGTCGCCGACGCCGAT
ATCGACAAGGTGATGAAGCGAACCGCGCGCCGGCCCTTGGCGCGGGAAGCGGTGCCGACCCGAAACGCGTTGGCACTCGG
GTTGACGTTGACGGTGATCTCGTTCTTCTGGCTATGGTGCGCCACGAACCTGCTGGCGGGGGTGCTGGCCCTGGTCACCG
TCGCGTTTTATGTGTTCGTCTACACGCTTTGGCTCAAGCGACGCACGTCACAGAACGTGGTGTGGGGTGGGGCGGCCGGC
TGTATGCCGGTGATGATCGGCTGGTCGGCCATCACCGGCACCATAGCCTGGCCGGCGCTGGCGATGTTCGCGATCATCTT
CTTCTGGACGCCGCCACACACCTGGGCATTGGCGATGCGCTACAAGCAGGACTACCAAGTGGCCGGGGTGCCGATGCTGC
CGGCGGTGGCGACCGAGCGTCAGGTCACCAAGCAGATCTTGATCTACACCTGGCTGACCGTGGCCGCGACGCTGGTGCTG
GCGTTGGCGACCAGTTGGCTTTACGGCGCGGTGGCCCTGGTGGCCGGTGGGTGGTTCCTGACGATGGCCCACCAGTTGTA
TGCCGGGGTGCGCGCCGGCGAGCCGGTCAGGCCGCTGCGGCTGTTTCTGCAGTCGAACAACTATCTGGCGGTGGTGTTCT
GCGCACTGGCCGTCGACTCGGTGATCGCGCTGCCCACGCTGCACTGA

Upstream 100 bases:

>100_bases
TCGTGTGAATCGACCCTGCGGCTCTGCTGCCACAGTTACCCGGTCTACCATCGTGCGTAGTAGAAGCTGCGCGCGGCTGC
GATTCCCGAGGAGTTAGTGC

Downstream 100 bases:

>100_bases
TTGGGGGCCCAGTTCCGCTGCGGTGCCGGCCCTGCTCGGCCAACGTAGTCAGATGGTTGGATCGCCACCGGCGCCACCGG
CGCCGCCCGCGCCACCAGCA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADAD
IDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH

Sequences:

>Translated_308_residues
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADAD
IDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH
>Mature_308_residues
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADAD
IDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=188, Percent_Identity=30.3191489361702, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1786631, Length=247, Percent_Identity=34.0080971659919, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325085, Length=277, Percent_Identity=24.9097472924188, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33539; Mature: 33539

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWC
HHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
AMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
VIALPTLH
HHHCCCCC
>Mature Secondary Structure
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWC
HHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
AMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
VIALPTLH
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]