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The map label for this gene is 148661108

Identifier: 148661108

GI number: 148661108

Start: 1483824

End: 1485527

Strand: Reverse

Name: 148661108

Synonym: MRA_1328

Alternate gene names: NA

Gene position: 1485527-1483824 (Counterclockwise)

Preceding gene: 148661111

Following gene: 148661107

Centisome position: 33.61

GC content: 61.85

Gene sequence:

>1704_bases
ATGCCATCCGAGAAGGCCACCACTCGACACTTGCCAGGGGCCGTCGAGACTCTCAGCCCGCGCACTGGACGACGGCCAGA
GACGCCCGCATACGGCTCATGGCTGCTTGGGCGCGTGTCGGAGAGCCCACGGATGCGGCGGGTACGTATCCAGGGCATGC
TGACCGTCGCCATTTTGGTCACGAACGTGATCGGGCTCATTGTCGGTGCCATGCTACTGACGGTCGCCTTTCCGAAACCA
AGCGTGATTTTGGACGCCCCGCATTGGGTGTCGTTCGGGATCGTTCCGGGATACTGCGTGCTCGCCTTCATACTGGGCAC
CTACTGGCTCACCAGGCAAACGGCTCGAGCGTTGCGGTGGGCAATCGAGGAACGCACCCCCAGCCATGATGAGGCGCGCA
GCGCTTTCCTAGTCCCACTGCGAGTGGCGTTGGCAGTTCTTTTCCTGTGGGGCGCCGCCGCAGCGTTGTGGACGATAATC
TACGGCCTGGCCAACCGGTTGTTTATCCCGCGGTTCCTGTTTTCGATGGGCGTCATCGGCGTTGTCGCAGCCACCAGCTG
CTATCTGTTAACCGAGTTTGCGCTTCGCCCGATGGCCGCCCAGGCGCTCGAAGTGGGAGCAACACCACGATCGCTGGTGC
GAGGCATCGTGGGCCGAACCATGCTGGTGTGGCTGCTCTGTTCAGGCGTACCCAATGTCGGTGTCGCCCTCACCGCCATC
TTCGACGATACGTTTTGGGAACTCTCCAATGATCAATTCATGATCACAGTGCTGATCCTGTGGGCACCACTGTTGATCTT
CGGATTCATCCTGATGTGGATTCTCGCTTGGCTGACGGCCACGCCTGTGCGCGTGGTCCGCGAGGCGCTCAACCGCGTAG
AGCAGGGCGATCTAAGCGGCGATCTGGTCGTATTCGACGGGACCGAACTCGGTGAGCTACAGCGTGGTTTCAACAGAATG
GTCGAGGGCCTGCGCGAGCGCGAACGCGTACGCGATCTCTTCGGCCGCCACGTCGGTCGCGAGGTCGCCGCAGCAGCCGA
ACGCGAGCGACCAAAACTGGGCGGCGAAGAGCGCCATGTCGCCGTCGTCTTCGTCGACATCGTCGGTTCAACTCAATTGG
TCACCAGCCGGCCTGCGGCAGAGGTCGTGATGCTACTCAACCGGTTCTTCACGGTAATCGTCGATGAAGTGAACCATCAC
CGTGGACTTGTCAACAAGTTTCAGGGAGACGCCTCGCTGGCAGTCTTCGGGGCCCCCAACCGCCTGAGCCATCCCGAAGA
TGCCGCGCTGGCCACCGCACGAGCCATCGCCGACCGGCTAGCCAGCGAAATGCCGGAGTGCCAAGCCGGCATCGGGGTAG
CGGCAGGTCAGGTTGTCGCCGGCAATGTCGGCGCCCACGAACGGTTCGAATACACCGTGATCGGCGAACCGGTCAACGAG
GCTGCACGACTGTGCGAACTGGCAAAATCATACCCGAGCCGATTGTTGGCGTCGTCGCAAACGTTGCGCGGTGCCAGTGA
AAACGAATGTGCCCGTTGGTCTTTAGGCGAGACCGTGACACTTCGCGGGCACGACCAGCCCATCCGGCTGACGTCGCCAG
TTCAACAGCTGCAGATGCCTGCTCAGTCGGCCGACATAGTCGGCGGTGCACTGGGCGATCACCAGACCCACACGATTTAC
CGTGGGGCGCATCCGACAGATTAG

Upstream 100 bases:

>100_bases
GACAGTGCACTGGGCGATGACTAGACGCACCCGACTCACCTTAGAGCGCGCAACGACGTTGTTCCTTAGAGCGTGACCGA
CACACTACGCTGACGTCACC

Downstream 100 bases:

>100_bases
GCTGACGCCACCATGCCGGCGAAAAAGACCATGGCGCAACGCCTGGGCCAGGCACTCGAGACGATGACCCGTCAGTGCGG
CCAGCTGCCCGAGACCCCGG

Product: putative adenylate cyclase

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKP
SVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTII
YGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI
FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRM
VEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHH
RGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE
AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIY
RGAHPTD

Sequences:

>Translated_567_residues
MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKP
SVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTII
YGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI
FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRM
VEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHH
RGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE
AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIY
RGAHPTD
>Mature_566_residues
PSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPS
VILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIY
GLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIF
DDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMV
EGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHR
GLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEA
ARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYR
GAHPTD

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1320_MYCTU (Q10633)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   D70769
- RefSeq:   NP_215836.1
- RefSeq:   NP_335810.1
- ProteinModelPortal:   Q10633
- SMR:   Q10633
- EnsemblBacteria:   EBMYCT00000003788
- EnsemblBacteria:   EBMYCT00000069236
- GeneID:   886906
- GeneID:   924699
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1362
- KEGG:   mtu:Rv1320c
- TIGR:   MT1362
- TubercuList:   Rv1320c
- GeneTree:   EBGT00050000015402
- HOGENOM:   HBG571123
- OMA:   RRRIRVQ
- ProtClustDB:   CLSK791097
- GO:   GO:0005829
- InterPro:   IPR001054
- InterPro:   IPR003660
- Gene3D:   G3DSA:3.30.70.1230
- SMART:   SM00044
- SMART:   SM00304

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP; SSF55073 A/G_cyclase

EC number: 4.6.1.1

Molecular weight: Translated: 61966; Mature: 61834

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS50125 GUANYLATE_CYCLASE_2; PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1de06b14)-; HASH(0x1e102760)-; HASH(0x1d807870)-; HASH(0x1af60bd0)-; HASH(0x1afebc50)-; HASH(0x1dfcc640)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW
HHHHHHHHHHHHHHHCCCCCCEEEECCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG
HCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN
EEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEECCCCCCCCEEEEEECCCHHH
AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEECCCCEEEECCCCCCCEECCCHHHHHCC
AQSADIVGGALGDHQTHTIYRGAHPTD
CHHHHHHCCCCCCCCCCEEECCCCCCH
>Mature Secondary Structure 
PSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW
HHHHHHHHHHHHHHHCCCCCCEEEECCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG
HCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN
EEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEECCCCCCCCEEEEEECCCHHH
AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEECCCCEEEECCCCCCCEECCCHHHHHCC
AQSADIVGGALGDHQTHTIYRGAHPTD
CHHHHHHCCCCCCCCCCEEECCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036