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The map label for this gene is mazG [H]

Identifier: 148660803

GI number: 148660803

Start: 1143979

End: 1144956

Strand: Direct

Name: mazG [H]

Synonym: MRA_1029

Alternate gene names: 148660803

Gene position: 1143979-1144956 (Clockwise)

Preceding gene: 148660802

Following gene: 148660804

Centisome position: 25.88

GC content: 62.07

Gene sequence:

>978_bases
ATGATTGTCGTCCTGGTCGACCCCCGGCGTCCGACACTGGTGCCTGTTGAAGCGATCGAGTTCCTGCGCGGCGAGGTGCA
ATACACCGAGGAAATGCCGGTCGCGGTGCCCTGGTCGCTACCAGCGGCTCGTTCGGCGCACGCCGGAAACGACGCGCCGG
TGTTGCTGTCGTCTGACCCCAACCATCCTGCTGTCATTACTCGACTGGCCGCCGGTGCCCGGCTGATCTCGGCACCGGAT
TCTCAGCGTGGCGAACGACTCGTCGACGCCGTCGCGATGATGGACAAGCTGCGCACCGCCGGACCGTGGGAAAGTGAGCA
GACTCACGACTCGCTGCGCAGATACCTGCTGGAGGAGACCTACGAGCTGTTGGACGCGGTCCGCAGCGGCAGTGTTGACC
AGCTGCGCGAAGAGCTTGGTGATCTCTTGCTGCAGGTCCTCTTTCACGCCCGGATCGCTGAGGATGCGTCGCAATCGCCG
TTCACCATCGACGACGTCGCCGACACACTGATGCGAAAGCTCGGCAATCGGGCGCCAGGAGTACTTGCGGGCGAATCGAT
TTCGCTCGAAGATCAACTGGCGCAATGGGAGGCAGCCAAGGCCTCGGAAAAGGCGCGAAAGTCGGTAGCCGACGATGTCC
ATACGGGCCAGCCGGAATTAGCGCTGGCGCAGAAGGTTATTCAGCGTGCCCAAAAGGCTGGGCTGCCCGCTCACCTGATC
CCCGATGAGATCACTTCTGTTTCGGTTTCAGCTGACGTAGATGCGGAAAACACGCTGCGCACTGCCGTTTTGGACTTTAT
TGACAGGCTGCGCTGTGCCGAGCGGGCAATTGCCGTCGCACGCCGGGGCAGCAACGTTGCCGAGCAGCTCGATGTGACGC
CGCTGGGTGTGATCACCGAGCAGGAGTGGCTCGCGCATTGGCCAACTGCTGTCAACGATTCCCGCGGCGGGTCCAAGAAA
CGTAAAGGCATGCGATAA

Upstream 100 bases:

>100_bases
TCGCTGGGAAACCGCGCCAGCATATTGGTATAACGAACCCTAGCCCGCCAGGCGAAGACGGCCGTGGTCGCAACACGACG
ATTAAGGAGCGACAACCGTG

Downstream 100 bases:

>100_bases
CCGCCCCGAGTGCGACGGGGTAGTCAACAAACCCATGGGACGATGATCGTGACGGAAGCCGGTATAGGTGCCCTACGAGG
GAGAGTTGTGTCGCCGAGAC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPD
SQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPELALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKK
RKGMR

Sequences:

>Translated_325_residues
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPD
SQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPELALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKK
RKGMR
>Mature_325_residues
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPD
SQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPELALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKK
RKGMR

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=152, Percent_Identity=38.8157894736842, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 35472; Mature: 35472

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDP
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEEEECCC
NHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEET
CCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
VLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPELALAQKVIQRAQKAGLPAHLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITE
CHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEECC
QEWLAHWPTAVNDSRGGSKKRKGMR
HHHHHHCCCCCCCCCCCCHHCCCCC
>Mature Secondary Structure
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDP
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEEEECCC
NHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEET
CCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
VLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPELALAQKVIQRAQKAGLPAHLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITE
CHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEECC
QEWLAHWPTAVNDSRGGSKKRKGMR
HHHHHHCCCCCCCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]