Click here to switch to the map view.

The map label for this gene is moeA1

Identifier: 148660775

GI number: 148660775

Start: 1111577

End: 1112857

Strand: Direct

Name: moeA1

Synonym: MRA_1001

Alternate gene names: 148660775

Gene position: 1111577-1112857 (Clockwise)

Preceding gene: 148660774

Following gene: 148660776

Centisome position: 25.15

GC content: 68.15

Gene sequence:

>1281_bases
GTGCGTTCTGTGGAGGAGCAGCAGGCTCGGATATCGGCCGCTGCGGTAGCCCCGAGGCCGATACGCGTTGCGATCGCCGA
GGCGCAGGGATTGATGTGCGCCGAAGAAGTGGTCACCGAACGTCCAATGCCCGGTTTTGATCAGGCCGCCATCGACGGCT
ACGCGGTGCGCAGTGTCGATGTGGCCGGTGTCGGTGATACCGGTGGTGTCCAAGTCTTTGCCGACCACGGCGATCTTGAC
GGTCGCGACGTGCTGACCCTACCGGTGATGGGAACCATCGAAGCCGGAGCGCGCACCCTGAGCAGGTTGCAGCCTCGCCA
AGCGGTCCGGGTGCAGACCGGCGCGCCGCTTCCCACCCTGGCCGATGCGGTCCTGCCGTTGCGGTGGACCGATGGCGGAA
TGTCTCGGGTGCGGGTGCTGCGCGGGGCGCCGTCGGGCGCCTACGTGCGGCGTGCGGGCGACGACGTGCAGCCCGGTGAT
GTGGCGGTGCGCGCGGGGACGATCATCGGCGCAGCCCAGGTGGGGTTGCTGGCGGCGGTCGGCCGTGAACGGGTGCTGGT
GCACCCTCGTCCGCGGCTGTCGGTGATGGCCGTCGGGGGCGAGTTGGTCGACATCTCGCGGACCCCGGGCAACGGGCAGG
TTTATGACGTCAACTCCTATGCCTTGGCTGCGGCGGGCCGGGATGCCTGTGCGGAGGTGAACCGGGTTGGCATCGTCAGC
AACGACCCTACGGAACTTGGCGAAATCGTCGAGGGCCAGCTCAATCGGGCTGAGGTCGTGGTGATCGCCGGCGGGGTGGG
CGGTGCGGCGGCAGAAGCGGTCAGGTCGGTGCTTTCCGAGCTCGGTGAGATGGAGGTCGTGCGGGTCGCCATGCATCCGG
GATCCGTGCAGGGCTTCGGACAGCTCGGCCGTGATGGTGTACCGACCTTTCTGCTGCCGGCCAACCCGGTCAGCGCCCTG
GTGGTCTTCGAGGTGATGGTTCGGCCGCTGATCCGGCTGTCGCTGGGTAAACGGCATCCGATGCGACGGATCGTGTCGGC
GCGCACGCTGTCGCCGATCACGTCGGTGGCCGGGCGCAAGGGCTACCTGCGTGGCCAGTTGATGCGTGATCAGGACAGCG
GCGAGTACCTGGTGCAGGCGCTGGGCGGCGCTCCGGGGGCGTCATCGCACCTGCTCGCGACGCTTGCCGAAGCGAACTGT
CTGGTTGTGGTTCCCACCGGGGCCGAGCAGATTCGCACGGGTGAGATCGTGGATGTCGCCTTCCTGGCTCAGCACGGCTG
A

Upstream 100 bases:

>100_bases
CGACTGGGTCTGACAGAGCAGTAGCCTGGCGACGATACGGCACGGACGGTTCCGGGGTGGGGGATGCCCGGCCCCATGGC
TCGACGGAAAGGCGGGCGCT

Downstream 100 bases:

>100_bases
GCCGAACCACGGCGACTCTGGTGAACTTATGGCGCTCGAATCCCCGGCATCCGGGATGGCCGATGGCCGTCGGGCCGCTG
CGGGTCTCGGCAGGCGTGAT

Product: molybdopterin biosynthesis protein MoeA1

Products: NA

Alternate protein names: MPT Mo-transferase 1

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLD
GRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSAL
VVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG

Sequences:

>Translated_426_residues
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLD
GRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSAL
VVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG
>Mature_426_residues
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLD
GRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSAL
VVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family

Homologues:

Organism=Homo sapiens, GI10880983, Length=411, Percent_Identity=31.1435523114355, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI66932975, Length=411, Percent_Identity=31.1435523114355, Blast_Score=146, Evalue=4e-35,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=31.5926892950392, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=364, Percent_Identity=28.021978021978, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17136978, Length=303, Percent_Identity=27.0627062706271, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24638841, Length=303, Percent_Identity=27.0627062706271, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOEA1_MYCTU (O05577)

Other databases:

- EMBL:   BX842575
- EMBL:   AE000516
- PIR:   E70601
- RefSeq:   NP_335456.1
- RefSeq:   YP_177776.1
- ProteinModelPortal:   O05577
- EnsemblBacteria:   EBMYCT00000002028
- EnsemblBacteria:   EBMYCT00000072435
- GeneID:   885404
- GeneID:   925593
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1023
- KEGG:   mtu:Rv0994
- TIGR:   MT1023
- TubercuList:   Rv0994
- GeneTree:   EBGT00050000016425
- HOGENOM:   HBG731522
- OMA:   QGLLCAE
- ProtClustDB:   CLSK799347
- GO:   GO:0005829
- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453
- Gene3D:   G3DSA:3.40.980.10
- SMART:   SM00852
- TIGRFAMs:   TIGR00177

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N; SSF53218 MoCF_biosynth; SSF63867 MoeA_C; SSF63882 MoeA_N

EC number: NA

Molecular weight: Translated: 44338; Mature: 44338

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTL
EECCCCCCCEEEEEECCCCCCCEEEEECCEECHHHHHHHHHHCCCCCEEEEECCCCCCHH
ADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAV
HHHEEEEEECCCCHHHHHEEECCCCCCEEECCCCCCCCCCEEEEECEEECHHHHHHHHHC
GRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS
CCCEEEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCEEEEECCCHHHHHCCCEEEEC
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFG
CCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHH
QLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRK
HCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCC
GYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVA
CCEECEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEE
FLAQHG
EEECCC
>Mature Secondary Structure
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTL
EECCCCCCCEEEEEECCCCCCCEEEEECCEECHHHHHHHHHHCCCCCEEEEECCCCCCHH
ADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAV
HHHEEEEEECCCCHHHHHEEECCCCCCEEECCCCCCCCCCEEEEECEEECHHHHHHHHHC
GRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS
CCCEEEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCEEEEECCCHHHHHCCCEEEEC
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFG
CCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHH
QLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRK
HCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCC
GYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVA
CCEECEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEE
FLAQHG
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036