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The map label for this gene is pepD [H]

Identifier: 148660764

GI number: 148660764

Start: 1100374

End: 1101768

Strand: Direct

Name: pepD [H]

Synonym: MRA_0990

Alternate gene names: 148660764

Gene position: 1100374-1101768 (Clockwise)

Preceding gene: 148660763

Following gene: 148660765

Centisome position: 24.9

GC content: 66.67

Gene sequence:

>1395_bases
ATGGCCAAGTTGGCCCGAGTAGTGGGCCTAGTACAGGAAGAGCAACCTAGCGACATGACGAATCACCCACGGTATTCGCC
ACCGCCGCAGCAGCCGGGAACCCCAGGTTATGCTCAGGGGCAGCAGCAAACGTACAGCCAGCAGTTCGACTGGCGTTACC
CACCGTCCCCGCCCCCGCAGCCAACCCAGTACCGTCAACCCTACGAGGCGTTGGGTGGTACCCGGCCGGGTCTGATACCT
GGCGTGATTCCGACCATGACGCCCCCTCCTGGGATGGTTCGCCAACGCCCTCGTGCAGGCATGTTGGCCATCGGCGCGGT
GACGATAGCGGTGGTGTCCGCCGGCATCGGCGGCGCGGCCGCATCCCTGGTCGGGTTCAACCGGGCACCCGCCGGCCCCA
GCGGCGGCCCAGTGGCTGCCAGCGCGGCGCCAAGCATCCCCGCAGCAAACATGCCGCCGGGGTCGGTCGAACAGGTGGCG
GCCAAGGTGGTGCCCAGTGTCGTCATGTTGGAAACCGATCTGGGCCGCCAGTCGGAGGAGGGCTCCGGCATCATTCTGTC
TGCCGAGGGGCTGATCTTGACCAACAACCACGTGATCGCGGCGGCCGCCAAGCCTCCCCTGGGCAGTCCGCCGCCGAAAA
CGACGGTAACCTTCTCTGACGGGCGGACCGCACCCTTCACGGTGGTGGGGGCTGACCCCACCAGTGATATCGCCGTCGTC
CGTGTTCAGGGCGTCTCCGGGCTCACCCCGATCTCCCTGGGTTCCTCCTCGGACCTGAGGGTCGGTCAGCCGGTGCTGGC
GATCGGGTCGCCGCTCGGTTTGGAGGGCACCGTGACCACGGGGATCGTCAGCGCTCTCAACCGTCCAGTGTCGACGACCG
GCGAGGCCGGCAACCAGAACACCGTGCTGGACGCCATTCAGACCGACGCCGCGATCAACCCCGGTAACTCCGGGGGCGCG
CTGGTGAACATGAACGCTCAACTCGTCGGAGTCAACTCGGCCATTGCCACGCTGGGCGCGGACTCAGCCGATGCGCAGAG
CGGCTCGATCGGTCTCGGTTTTGCGATTCCAGTCGACCAGGCCAAGCGCATCGCCGACGAGTTGATCAGCACCGGCAAGG
CGTCACATGCCTCCCTGGGTGTGCAGGTGACCAATGACAAAGACACCCTGGGCGCCAAGATCGTCGAAGTAGTGGCCGGT
GGTGCTGCCGCGAACGCTGGAGTGCCGAAGGGCGTCGTTGTCACCAAGGTCGACGACCGCCCGATCAACAGCGCGGACGC
GTTGGTTGCCGCCGTGCGGTCCAAAGCGCCGGGCGCCACGGTGGCGCTAACCTTTCAGGATCCCTCGGGCGGTAGCCGCA
CAGTGCAAGTCACCCTCGGCAAGGCGGAGCAGTGA

Upstream 100 bases:

>100_bases
TCTCGGGGTTCGGCGAACGTTATCTCAGTGGAATCTCAGTCCACGCGCGCAACCTAGTTGTGCAGTTACTGTTGAAAGCC
ACACCCATGCCAGTCCACGC

Downstream 100 bases:

>100_bases
TGAAGGTCGCCGCGCAGTGTTCAAAGCTCGGATATACGGTGGCACCCATGGAACAGCGTGCGGAGTTGGTGGTTGGCCGG
GCACTTGTCGTCGTCGTTGA

Product: serine protease PepD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIP
GVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVA
AKVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVV
RVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGA
LVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAG
GAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ

Sequences:

>Translated_464_residues
MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIP
GVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVA
AKVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVV
RVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGA
LVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAG
GAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ
>Mature_463_residues
AKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPG
VIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAA
KVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVVR
VQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGAL
VNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGG
AAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=309, Percent_Identity=33.0097087378641, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4506141, Length=219, Percent_Identity=36.986301369863, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=31.5286624203822, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI24308541, Length=307, Percent_Identity=31.9218241042345, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1789629, Length=290, Percent_Identity=39.3103448275862, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1786356, Length=274, Percent_Identity=39.7810218978102, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1789630, Length=337, Percent_Identity=32.6409495548961, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646839, Length=325, Percent_Identity=33.8461538461538, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 46453; Mature: 46322

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQ
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
PTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAA
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHCCCCHHH
ASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEE
HHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCC
GSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVV
CCEEEEEECCEEEECCEEEEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCEEEE
RVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQN
EEECCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
TVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQ
HHHHHHHCCCCCCCCCCCCEEEECCEEEEECCHHHHHCCCCCCCCCCCCEEEEEECCHHH
AKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGGAAANAGVPKGVVVTKVDDR
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
PINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ
CCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
AKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQ
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
PTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAA
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHCCCCHHH
ASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEE
HHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCC
GSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVV
CCEEEEEECCEEEECCEEEEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCCCCEEEE
RVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQN
EEECCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
TVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQ
HHHHHHHCCCCCCCCCCCCEEEECCEEEEECCHHHHHCCCCCCCCCCCCEEEEEECCHHH
AKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGGAAANAGVPKGVVVTKVDDR
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
PINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ
CCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]