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The map label for this gene is mprB [H]

Identifier: 148660763

GI number: 148660763

Start: 1098816

End: 1100330

Strand: Direct

Name: mprB [H]

Synonym: MRA_0989

Alternate gene names: 148660763

Gene position: 1098816-1100330 (Clockwise)

Preceding gene: 148660762

Following gene: 148660764

Centisome position: 24.86

GC content: 65.08

Gene sequence:

>1515_bases
ATGTGGTGGTTCCGCCGCCGAGACCGGGCGCCGCTGCGCGCCACCAGCTCATTATCCCTGCGGTGGCGGGTCATGCTGCT
GGCGATGTCCATGGTCGCGATGGTGGTTGTGCTGATGTCGTTCGCCGTCTATGCGGTGATCTCGGCCGCGCTCTACAGCG
ACATCGACAACCAACTGCAGAGCCGGGCGCAACTGCTCATCGCCAGTGGCTCGCTGGCAGCTGATCCGGGTAAGGCAATC
GAGGGTACCGCCTATTCGGATGTCAACGCGATGCTGGTCAACCCCGGCCAGTCCATCTACACCGCTCAACAGCCGGGCCA
GACGCTGCCGGTCGGTGCTGCCGAGAAGGCGGTGATCCGTGGCGAGTTGTTCATGTCGCGGCGCACCACCGCCGACCAAC
GGGTGCTTGCCATCCGTCTGACCAACGGTAGTTCGCTGCTGATCTCCAAAAGTCTCAAGCCCACCGAAGCAGTCATGAAC
AAGCTGCGTTGGGTGCTATTGATCGTGGGTGGGATCGGGGTGGCGGTCGCCGCGGTGGCCGGGGGGATGGTCACCCGGGC
CGGGCTGAGGCCGGTGGGCCGCCTCACCGAAGCGGCCGAGCGGGTGGCGCGAACCGACGACCTGCGGCCCATCCCCGTCT
TCGGCAGCGACGAATTGGCCAGGCTGACAGAGGCATTCAATTTAATGCTGCGGGCGCTGGCCGAGTCACGGGAACGGCAG
GCAAGGCTGGTTACCGACGCCGGACATGAATTGCGTACCCCGCTAACGTCGCTGCGCACCAATGTCGAACTCTTGATGGC
CTCGATGGCCCCGGGGGCTCCGCGGCTACCCAAGCAGGAGATGGTCGACCTGCGTGCCGATGTGCTGGCTCAAATCGAGG
AATTGTCCACACTGGTAGGCGATTTGGTGGACCTGTCCCGAGGCGACGCCGGAGAAGTGGTGCACGAGCCGGTCGACATG
GCTGACGTCGTCGACCGCAGCCTGGAGCGGGTCAGGCGGCGGCGCAACGATATCCTTTTCGACGTCGAGGTGATTGGGTG
GCAGGTTTATGGCGATACCGCTGGATTGTCGCGGATGGCGCTTAACCTGATGGACAACGCCGCGAAGTGGAGCCCGCCGG
GCGGCCACGTGGGTGTCAGGCTGAGCCAGCTCGACGCGTCGCACGCTGAGCTGGTGGTTTCCGACCGCGGCCCGGGCATT
CCCGTGCAGGAGCGCCGTCTGGTGTTTGAACGGTTTTACCGGTCGGCATCGGCACGGGCGTTGCCGGGTTCGGGCCTCGG
GTTGGCGATCGTCAAACAGGTGGTGCTCAACCACGGCGGATTGCTGCGCATCGAAGACACCGACCCAGGCGGCCAGCCCC
CTGGAACGTCGATTTACGTGCTGCTCCCCGGCCGTCGGATGCCGATTCCGCAGCTTCCCGGTGCGACGGCTGGCGCTCGG
AGCACGGACATCGAGAACTCTCGGGGTTCGGCGAACGTTATCTCAGTGGAATCTCAGTCCACGCGCGCAACCTAG

Upstream 100 bases:

>100_bases
ACGTCGGGTATCTACGCCGCAAGACCGAGGCCGACGGCGAGCCGCGGCTGATCCACACTGTGCGCGGAGTGGGTTACGTG
CTACGTGAAACACCACCCTG

Downstream 100 bases:

>100_bases
TTGTGCAGTTACTGTTGAAAGCCACACCCATGCCAGTCCACGCATGGCCAAGTTGGCCCGAGTAGTGGGCCTAGTACAGG
AAGAGCAACCTAGCGACATG

Product: putative two component sensor kinase MprB

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDM
ADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGI
PVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT

Sequences:

>Translated_504_residues
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDM
ADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGI
PVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT
>Mature_504_residues
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDM
ADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGI
PVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=31.4878892733564, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=27.8688524590164, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=27.9569892473118, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=34.4339622641509, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=29.1512915129151, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=27.741935483871, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=30.8474576271186, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=27.6752767527675, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=458, Percent_Identity=23.5807860262009, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=27.4305555555556, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=25.6410256410256, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=230, Percent_Identity=26.9565217391304, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=276, Percent_Identity=26.4492753623188, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=25.4681647940075, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=26.3888888888889, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54409; Mature: 54409

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIR
HHHHEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCHHHHHHH
GELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVA
HHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVG
HHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMA
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCCCHHHHH
LNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARA
HHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
LPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
STDIENSRGSANVISVESQSTRAT
CCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIR
HHHHEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCHHHHHHH
GELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVA
HHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVG
HHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMA
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCCCHHHHH
LNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARA
HHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
LPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
STDIENSRGSANVISVESQSTRAT
CCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14638785; 12788972 [H]