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The map label for this gene is mntH [H]

Identifier: 148660703

GI number: 148660703

Start: 1031886

End: 1033172

Strand: Reverse

Name: mntH [H]

Synonym: MRA_0932

Alternate gene names: 148660703

Gene position: 1033172-1031886 (Counterclockwise)

Preceding gene: 148660704

Following gene: 148660702

Centisome position: 23.38

GC content: 65.35

Gene sequence:

>1287_bases
GTGGCGGGCGAATTTCGGTTACTCTCGCATCTTTGTTCGCGTGGATCGAAAGTCGGTGAGTTGGCCCAGGACACCCGGAC
TTCCCTGAAGACGAGCTGGTATCTGCTCGGGCCAGCCTTTGTCGCGGCCATCGCCTACGTCGACCCCGGGAACGTGGCAG
CCAACGTCAGCTCCGGCGCCCAGTTCGGCTACCTGTTGTTATGGGTGATCGTCGCCGCCAACGTGATGGCCGCCCTGGTG
CAGTACCTGTCGGCAAAGCTCGGGCTGGTGACCGGACGCTCACTGCCGGAAGCGATCGGCAAGCGAATGGGACGCCCGGC
CCGGCTGGCCTACTGGGCACAGGCCGAGATCGTCGCGATGGCAACCGATGTGGCCGAAGTGATCGGCGGAGCTATCGCAT
TGCGGATCATGTTCAACCTGCCGCTGCCGATCGGCGGGATCATCACCGGGGTGGTCTCGCTGCTGCTGCTGACGATCCAG
GATCGGCGCGGTCAACGTTTGTTCGAGCGCGTCATCACCGCCTTGCTGCTGGTGATTGCCATCGGCTTCACCGCCAGTTT
CTTCGTCGTGACACCACCCCCCAATGCGGTCCTCGGCGGTTTGGCACCGCGCTTTCAGGGAACCGAGAGCGTTCTTTTGG
CCGCGGCGATCATGGGGGCGACCGTCATGCCGCACGCCGTCTACCTGCATTCAGGTCTCGCGCGCGACCGGCACGGGCAT
CCCGATCCGGGCCCTCAGCGGCGCCGGCTGCTGCGCGTCACCCGCTGGGATGTCGGCCTGGCGATGCTGATAGCCGGCGG
GGTAAACGCCGCGATGCTGCTGGTTGCCGCGCTGAACATGCGGGGCCGTGGGGACACCGCCTCGATCGAAGGCGCCTACC
ACGCCGTCCACGACACCTTGGGGGCGACGATCGCGGTGCTCTTCGCGGTCGGGTTGCTGGCGTCCGGCTTGGCGTCGTCG
TCGGTGGGTGCTTACGCCGGCGCGATGATCATGCAGGGGCTGCTGCACTGGAGCGTTCCCATGCTGGTGCGCCGCCTAAT
CACGCTGGGCCCCGCGTTGGCGATACTTACGCTGGGCTTCGACCCCACCCGCACATTGGTGCTCTCACAGGTGGTGCTGT
CGTTCGGTATTCCGTTTGCGGTACTTCCACTGGTCAAACTCACCGGCAGCCCCGCGGTGATGGGCGGCGACACCAACCAT
CGCGCCACGACTTGGGTTGGCTGGGTGGTCGCGGTGATGGTTAGTCTGCTCAACGTGATGCTGATCTATCTCACGGTGAC
CGGCTGA

Upstream 100 bases:

>100_bases
TACGGCAATCAACGCACCAAGTGGGACGCCGGCTGCCGGCCGGACTTCGCCAACCCCGACTACCGATAGCCAGCGGAGGT
CCCGAGTAGCCCGGTGGTTG

Downstream 100 bases:

>100_bases
ATGCCGGACCGCCGGCATCCCTACTTCGCCTACGGGTCCAACCTGTGCGCCCACCAGATGGCGTCGCGCTGTCCCGACGC
CGGTGCTCCGCGGCCGGCAG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: BRAMP [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALV
QYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQ
DRRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGH
PDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASS
SVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNH
RATTWVGWVVAVMVSLLNVMLIYLTVTG

Sequences:

>Translated_428_residues
MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALV
QYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQ
DRRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGH
PDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASS
SVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNH
RATTWVGWVVAVMVSLLNVMLIYLTVTG
>Mature_427_residues
AGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQ
YLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQD
RRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGHP
DPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASSS
VGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHR
ATTWVGWVVAVMVSLLNVMLIYLTVTG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=442, Percent_Identity=29.6380090497738, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI295293175, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI295293173, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI10835169, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI295293178, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI295293171, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI295293169, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI295293167, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1788736, Length=407, Percent_Identity=43.2432432432432, Blast_Score=315, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI193210616, Length=460, Percent_Identity=27.1739130434783, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17569473, Length=399, Percent_Identity=30.3258145363409, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71999499, Length=452, Percent_Identity=27.4336283185841, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71993856, Length=239, Percent_Identity=35.1464435146443, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323062, Length=391, Percent_Identity=33.7595907928389, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321841, Length=415, Percent_Identity=30.8433734939759, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324450, Length=415, Percent_Identity=28.9156626506024, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24648607, Length=447, Percent_Identity=29.3064876957494, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI281362176, Length=447, Percent_Identity=29.3064876957494, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24648609, Length=447, Percent_Identity=29.3064876957494, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI45553443, Length=418, Percent_Identity=30.3827751196172, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005025
- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF03358 FMN_red; PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45005; Mature: 44874

Theoretical pI: Translated: 10.73; Mature: 10.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHHEECCCCCEECCCCCC
QFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHHHHHHHHH
ATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIA
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGH
HHCCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCC
PDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
GATIAVLFAVGLLASGLASSSVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGF
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
DPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVM
CHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LIYLTVTG
HHHHEECC
>Mature Secondary Structure 
AGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECHHHHHHHHEECCCCCEECCCCCC
QFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHHHHHHHHH
ATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIA
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGH
HHCCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCC
PDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
GATIAVLFAVGLLASGLASSSVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGF
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
DPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVM
CHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LIYLTVTG
HHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972; 9632246 [H]