The gene/protein map for NC_009525 is currently unavailable.
Definition Mycobacterium tuberculosis H37Ra, complete genome.
Accession NC_009525
Length 4,419,977

Click here to switch to the map view.

The map label for this gene is ligD [H]

Identifier: 148660628

GI number: 148660628

Start: 948947

End: 949774

Strand: Reverse

Name: ligD [H]

Synonym: MRA_0859

Alternate gene names: 148660628

Gene position: 949774-948947 (Counterclockwise)

Preceding gene: 148660630

Following gene: 148660623

Centisome position: 21.49

GC content: 66.06

Gene sequence:

>828_bases
GTGGACGGGTTTCCCGGGCGCGGTGCGGTCATCACTGGCGGTGCCAGTGGCATCGGGTTGGCTACCGGCACCGAGTTCGC
CCGCCGCGGAGCCAGAGTCGTGCTAGGGGACGTTGACAAGCCGGGACTTCGGCAGGCGGTGAACCACCTGCGTGCCGAGG
GGTTCGATGTGCACAGCGTGATGTGCGACGTCCGGCATCGAGAAGAGGTCACTCACCTCGCGGACGAGGCTTTCCGCCTG
CTCGGCCACGTCGATGTCGTATTCAGCAACGCCGGCATCGTTGTCGGCGGTCCGATCGTGGAGATGACGCACGACGACTG
GCGTTGGGTGATCGACGTCGACCTGTGGGGCTCGATCCATACGGTCGAAGCGTTCCTGCCGAGGTTGCTTGAGCAGGGCA
CGGGCGGGCATGTGGTGTTCACCGCGTCCTTTGCCGGGCTGGTGCCCAATGCCGGACTCGGCGCATACGGCGTTGCCAAG
TACGGGGTTGTCGGTCTGGCGGAGACGCTGGCCCGCGAGGTCACCGCCGACGGCATTGGGGTGTCGGTGCTCTGCCCGAT
GGTCGTCGAAACCAATCTGGTTGCCAACTCTGAACGAATCCGAGGCGCGGCTTGCGCGCAGTCCTCAACGACGGGATCGC
CCGGTCCACTCCCCCTGCAGGACGACAACCTGGGCGTCGACGATATCGCCCAGCTAACAGCCGATGCGATTCTGGCCAAC
CGCCTCTACGTCCTTCCGCATGCGGCCTCGCGCGCTTCGATCCGCCGCAGGTTCGAGCGCATTGACCGCACCTTCGACGA
ACAGGCCGCCGAGGGGTGGCGGCATTAG

Upstream 100 bases:

>100_bases
TTGTGAACACCGCGACGCAACATGCCGCTGTGGCGTCGCCAGAATCACGCTCGCCCGGCGCAGTCGACGCGGGTGACTGC
CTGAAATAGGGTTGCGTGCT

Downstream 100 bases:

>100_bases
CTTTGATTTTCCTTAAGGCTCGATGTCAGATGGTGCGTCATGTCGGCATGTCGTCGCGCATCCCATCTCTTGTCAGCATC
GGGTATGAGGGAAGAACCGT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEAFRL
LGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAK
YGVVGLAETLAREVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPLQDDNLGVDDIAQLTADAILAN
RLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH

Sequences:

>Translated_275_residues
MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEAFRL
LGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAK
YGVVGLAETLAREVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPLQDDNLGVDDIAQLTADAILAN
RLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH
>Mature_275_residues
MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEAFRL
LGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAK
YGVVGLAETLAREVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPLQDDNLGVDDIAQLTADAILAN
RLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH

Specific function: Catalyzes the C alpha dehydrogenation of arylglycerol- beta-aryl ether (C alpha alcohol type) (compound IV) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40807363, Length=243, Percent_Identity=30.0411522633745, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=31.0880829015544, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI142976729, Length=194, Percent_Identity=31.4432989690722, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI25282469, Length=224, Percent_Identity=32.1428571428571, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI210032110, Length=194, Percent_Identity=30.9278350515464, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=30.4347826086957, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310128830, Length=251, Percent_Identity=26.6932270916335, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI310115468, Length=251, Percent_Identity=26.6932270916335, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI5031737, Length=191, Percent_Identity=29.3193717277487, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=29.7872340425532, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40254992, Length=186, Percent_Identity=31.1827956989247, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4503817, Length=204, Percent_Identity=28.4313725490196, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI20149619, Length=239, Percent_Identity=26.3598326359833, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4504505, Length=192, Percent_Identity=31.7708333333333, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI66933014, Length=202, Percent_Identity=25.7425742574257, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI126723750, Length=196, Percent_Identity=27.0408163265306, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI15277342, Length=193, Percent_Identity=30.0518134715026, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758504, Length=199, Percent_Identity=30.6532663316583, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19923817, Length=193, Percent_Identity=26.4248704663212, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI31543615, Length=147, Percent_Identity=31.2925170068027, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=26.3681592039801, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI83715985, Length=182, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI223718074, Length=181, Percent_Identity=29.2817679558011, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI87082100, Length=236, Percent_Identity=29.2372881355932, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787335, Length=205, Percent_Identity=29.2682926829268, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1786701, Length=191, Percent_Identity=30.3664921465969, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789208, Length=198, Percent_Identity=25.2525252525253, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788459, Length=186, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787905, Length=188, Percent_Identity=28.1914893617021, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786812, Length=210, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=188, Percent_Identity=25, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367365, Length=194, Percent_Identity=30.4123711340206, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787820, Length=246, Percent_Identity=23.9837398373984, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=248, Percent_Identity=29.8387096774194, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193203117, Length=241, Percent_Identity=30.7053941908714, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI193203115, Length=241, Percent_Identity=30.7053941908714, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17567345, Length=197, Percent_Identity=32.48730964467, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17508895, Length=226, Percent_Identity=26.1061946902655, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=188, Percent_Identity=29.2553191489362, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=192, Percent_Identity=27.6041666666667, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=187, Percent_Identity=31.5508021390374, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=217, Percent_Identity=27.6497695852535, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=187, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=216, Percent_Identity=27.3148148148148, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=207, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=208, Percent_Identity=29.8076923076923, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=208, Percent_Identity=29.8076923076923, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=32.6424870466321, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320089, Length=193, Percent_Identity=25.9067357512953, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=195, Percent_Identity=31.7948717948718, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281364892, Length=198, Percent_Identity=32.8282828282828, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24640492, Length=200, Percent_Identity=28, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581726, Length=194, Percent_Identity=29.3814432989691, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859837, Length=197, Percent_Identity=34.5177664974619, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=31.1764705882353, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28571387, Length=210, Percent_Identity=29.5238095238095, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24644339, Length=191, Percent_Identity=29.3193717277487, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI23397609, Length=184, Percent_Identity=30.9782608695652, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358495, Length=221, Percent_Identity=25.3393665158371, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639444, Length=192, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24665243, Length=205, Percent_Identity=31.7073170731707, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24663911, Length=218, Percent_Identity=29.3577981651376, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221331218, Length=205, Percent_Identity=31.7073170731707, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510726, Length=196, Percent_Identity=28.0612244897959, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356301, Length=188, Percent_Identity=28.7234042553192, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24665247, Length=206, Percent_Identity=31.5533980582524, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221331216, Length=206, Percent_Identity=31.5533980582524, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737361, Length=207, Percent_Identity=27.0531400966184, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641388, Length=206, Percent_Identity=31.5533980582524, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=25.6410256410256, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641232, Length=213, Percent_Identity=28.169014084507, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571526, Length=194, Percent_Identity=24.2268041237113, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29249; Mature: 29249

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSV
CCCCCCCCEEEECCCCCCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHH
MCDVRHREEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIH
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEECCCEEEEECCCCEEEEEEECCCCHH
TVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIG
HHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
VSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPLQDDNLGVDDIAQLTADAILAN
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSV
CCCCCCCCEEEECCCCCCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHH
MCDVRHREEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIH
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEECCCEEEEECCCCEEEEEEECCCCHH
TVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIG
HHHHHHHHHHHCCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
VSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPLQDDNLGVDDIAQLTADAILAN
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1744051; 8495726; 7764263 [H]