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The map label for this gene is purL [H]

Identifier: 148660581

GI number: 148660581

Start: 897126

End: 899390

Strand: Direct

Name: purL [H]

Synonym: MRA_0813

Alternate gene names: 148660581

Gene position: 897126-899390 (Clockwise)

Preceding gene: 148660579

Following gene: 148660582

Centisome position: 20.3

GC content: 67.68

Gene sequence:

>2265_bases
GTGCTGGACACCGTCGAACACGCCGCGACCACACCCGACCAACCACAACCGTATGGTGAGCTGGGCCTCAAAGACGACGA
GTACCGGCGGATTCGCCAGATCCTGGGCCGCCGGCCCACCGACACCGAGCTGGCCATGTACTCGGTGATGTGGAGCGAAC
ACTGTTCGTACAAGTCCTCCAAGGTGCACCTGCGCTACTTCGGTGAGACCACCTCCGACGAGATGCGCGCGGCCATGCTG
GCCGGCATCGGCGAGAACGCCGGCGTCGTCGACATCGGCGACGGCTGGGCGGTCACCTTCAAGGTGGAGTCACACAACCA
CCCGTCCTACGTCGAGCCCTACCAGGGCGCGGCCACCGGGGTGGGCGGCATCGTCCGCGACATCATGGCCATGGGCGCCC
GACCGGTCGCCGTGATGGACCAGCTTCGGTTCGGCGCCGCCGACGCCCCCGATACCCGCCGCGTGCTCGACGGCGTGGTC
CGCGGCATCGGCGGATACGGCAACTCCCTGGGCCTGCCCAACATTGGCGGAGAGACCGTCTTCGACCCGTGCTACGCCGG
CAACCCCTTAGTGAACGCGTTGTGTGTCGGCGTATTACGGCAGGAGGACCTGCATTTGGCGTTCGCCTCCGGCGCCGGCA
ACAAGATCATCCTGTTTGGCGCGCGCACCGGGCTCGACGGTATCGGCGGGGTGTCGGTGCTGGCGTCGGACACCTTCGAT
GCCGAGGGATCCCGCAAGAAGCTGCCCTCGGTGCAGGTCGGCGACCCGTTCATGGAGAAGGTGCTCATCGAATGCTGTCT
CGAGCTCTACGCGGGCGGCCTGGTGATCGGCATCCAAGACCTGGGCGGAGCCGGATTATCTTGTGCCACATCGGAGTTAG
CATCCGCCGGTGATGGCGGAATGACGATCCAGCTGGACAGCGTCCCGCTGCGGGCCAAGGAGATGACGCCCGCCGAGGTG
CTCTGCAGCGAATCGCAGGAGCGGATGTGCGCGGTGGTCTCCCCGAAGAACGTCGACGCATTCCTGGCGGTGTGCCGCAA
GTGGGAGGTGCTGGCGACGGTGATCGGCGAGGTCACCGACGGCGACCGGCTGCAGATCACCTGGCACGGCGAGACGGTGG
TCGACGTGCCGCCGCGCACCGTAGCTCACGAAGGTCCGGTATATCAGCGCCCGGTCGCCCGCCCCGATACGCAGGACGCG
CTGAACGCCGACCGCTCGGCCAAGCTGTCACGGCCGGTCACCGGCGACGAGCTGCGCGCGACTTTGCTTGCGTTACTTGG
CAGCCCGCACCTGTGCAGCCGCGCGTTCATCACCGAGCAGTACGACCGCTATGTGCGCGGCAACACGGTGCTCGCCGAGC
ACGCCGACGGCGGCATGCTGCGCATCGACGAGTCGACCGGCCGGGGCATCGCGGTATCGACCGACGCGTCGGGACGCTAC
ACGCTGCTGGATCCCTACGCTGGCGCGCAACTCGCGTTGGCCGAGGCGTACCGCAACGTCGCCGTCACCGGCGCCACCCC
GGTCGCGGTGACCAACTGCCTGAACTTCGGTTCCCCCGAGGACCCCGGCGTGATGTGGCAGTTCACGCAGGCGGTCCGCG
GTCTGGCCGATGGCTGTGCGGACCTCGGGATTCCGGTGACCGGTGGCAACGTGAGTTTCTACAACCAAACCGGTTCGGCG
GCAATCCTGCCCACGCCGGTGGTCGGGGTGCTCGGCGTCATCGACGATGTGCGTCGGCGCATCCCTACCGGCCTGGGCGC
CGAGCCCGGGGAAACGTTGATGCTGTTGGGCGACACCCGCGACGAGTTCGACGGTTCCGTGTGGGCGCAGGTGACCGCAG
ACCACCTGGGTGGATTGCCGCCGGTAGTCGATCTGGCGCGGGAGAAGCTGCTGGCCGCGGTGCTGAGCTCGGCGTCGCGG
GACGGGCTAGTGTCCGCGGCGCACGATCTGTCCGAGGGTGGGCTGGCCCAAGCCATCGTGGAATCGGCGTTAGCGGGTGA
AACCGGTTGCCGCATAGTGCTTCCCGAAGGGGCTGACCCGTTTGTGCTGCTGTTCTCCGAGTCGGCGGGTCGGGTGCTGG
TCGCGGTGCCACGCACCGAGGAGAGCCGGTTTCGCGGGATGTGTGAGGCGCGGGGACTTCCCGCGGTCCGCATCGGCGTC
GTCGATCAAGGTTCGGACGCGGTTGAGGTGCAGGGCTTGTTCGCGGTGTCGTTGGCCGAACTGCGTGCGACATCCGAGGC
GGTGTTGCCGCGATACTTCGGATGA

Upstream 100 bases:

>100_bases
TCCGTCGGCTTGTCCGTGTCAACGCGGCCGCAGCGCGATGGGGCCTAGCTAGACTGCCTCCGTGATGTCTCCGCTCGCCC
GGACCCCGCGCAAAACGTCG

Downstream 100 bases:

>100_bases
GTCGGCTTCGCGCCCTGTCTTTGGCCGCCGGCCTGGTCGGCTGGAGTCTGGTCAGCCCGCGGCTGCCGGCGCCGTGGCGG
ATTCCGTTGCAGGCGGGGCT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTSDEMRAAML
AGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFD
AEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEV
LCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDA
LNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRY
TLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSA
AILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASR
DGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGV
VDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG

Sequences:

>Translated_754_residues
MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTSDEMRAAML
AGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFD
AEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEV
LCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDA
LNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRY
TLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSA
AILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASR
DGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGV
VDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG
>Mature_754_residues
MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTSDEMRAAML
AGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFD
AEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEV
LCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDA
LNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRY
TLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSA
AILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASR
DGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGV
VDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=670, Percent_Identity=24.0298507462687, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI48994899, Length=776, Percent_Identity=26.9329896907216, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17553022, Length=684, Percent_Identity=23.6842105263158, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321498, Length=811, Percent_Identity=24.9075215782984, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24582111, Length=718, Percent_Identity=25.2089136490251, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24582109, Length=718, Percent_Identity=25.2089136490251, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17137292, Length=718, Percent_Identity=25.2089136490251, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79508; Mature: 79508

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSS
CCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
KVHLRYFGETTSDEMRAAMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATG
EEEEEECCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCCC
VGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETV
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
FDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFD
CCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCEEEEECCCCC
AEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGG
CCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
MTIQLDSVPLRAKEMTPAEVLCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTD
EEEEECCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
GDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDALNADRSAKLSRPVTGDELRA
CCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHH
TLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRY
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCE
TLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCA
EEECCCCCCHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DLGIPVTGGNVSFYNQTGSAAILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTR
HCCCEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
DEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIV
CCCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHH
ESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGV
HHHHCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEE
VDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG
EECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSS
CCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
KVHLRYFGETTSDEMRAAMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATG
EEEEEECCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCCC
VGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETV
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
FDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFD
CCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCEEEEECCCCC
AEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGG
CCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
MTIQLDSVPLRAKEMTPAEVLCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTD
EEEEECCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
GDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDALNADRSAKLSRPVTGDELRA
CCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHH
TLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRY
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCE
TLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCA
EEECCCCCCHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DLGIPVTGGNVSFYNQTGSAAILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTR
HCCCEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
DEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIV
CCCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHH
ESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGV
HHHHCCCCCCEEEECCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEE
VDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG
EECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA