| Definition | Mycobacterium tuberculosis H37Ra, complete genome. |
|---|---|
| Accession | NC_009525 |
| Length | 4,419,977 |
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The map label for this gene is dnaJ1
Identifier: 148660118
GI number: 148660118
Start: 423814
End: 425001
Strand: Direct
Name: dnaJ1
Synonym: MRA_0361
Alternate gene names: 148660118
Gene position: 423814-425001 (Clockwise)
Preceding gene: 148660117
Following gene: 148660119
Centisome position: 9.59
GC content: 67.51
Gene sequence:
>1188_bases ATGGCCCAAAGGGAATGGGTCGAAAAAGACTTCTACCAGGAGCTGGGCGTCTCCTCTGATGCCAGTCCTGAAGAGATCAA ACGTGCCTATCGGAAGTTGGCGCGCGACCTGCATCCGGACGCGAACCCGGGCAACCCGGCCGCCGGCGAACGGTTCAAGG CGGTTTCGGAGGCGCATAACGTGCTGTCGGATCCGGCCAAGCGCAAGGAGTACGACGAAACCCGCCGCCTGTTCGCCGGC GGCGGGTTCGGCGGCCGTCGGTTCGACAGCGGCTTTGGGGGCGGGTTCGGCGGTTTCGGGGTCGGTGGAGACGGCGCCGA GTTCAACCTCAACGACTTGTTCGACGCCGCCAGCCGAACCGGCGGTACCACCATCGGTGACTTGTTCGGTGGCTTGTTCG GACGCGGTGGCAGCGCCCGTCCCAGCCGCCCGCGACGCGGCAACGACCTGGAGACCGAGACCGAGTTGGATTTCGTGGAG GCCGCCAAGGGCGTGGCGATGCCGCTGCGATTAACCAGCCCGGCGCCGTGCACCAACTGCCATGGCAGCGGGGCCCGGCC AGGCACCAGCCCAAAGGTGTGTCCCACTTGCAACGGGTCGGGCGTGATCAACCGCAATCAGGGCGCGTTCGGCTTCTCCG AGCCGTGCACCGACTGCCGAGGTAGCGGCTCGATCATCGAGCACCCCTGCGAGGAGTGCAAAGGCACCGGCGTGACCACC CGCACCCGAACCATCAACGTGCGGATCCCGCCCGGTGTCGAGGATGGGCAGCGCATCCGGCTAGCCGGTCAGGGCGAGGC CGGGTTGCGCGGCGCTCCCTCGGGGGATCTCTACGTGACGGTGCATGTGCGGCCCGACAAGATCTTCGGCCGCGACGGCG ACGACCTCACCGTCACCGTTCCGGTCAGCTTCACCGAATTGGCTTTGGGCTCGACGCTGTCGGTGCCTACCCTGGACGGC ACGGTCGGGGTCCGGGTGCCCAAAGGCACCGCTGACGGCCGCATTCTGCGTGTGCGCGGACGCGGTGTGCCCAAGCGCAG TGGGGGTAGCGGCGACCTACTTGTCACCGTGAAGGTGGCCGTGCCGCCCAATTTGGCAGGCGCCGCTCAGGAAGCTCTGG AAGCCTATGCGGCGGCGGAGCGGTCCAGTGGTTTCAACCCGCGGGCCGGATGGGCAGGTAATCGCTGA
Upstream 100 bases:
>100_bases CTGACCAGGGCAATAGCGCCGACACCTCGGGCGAACAGGCAGAATCAGAACCGTCGGGCAGTTAACAACAAAAGAGGAAG GCGAGAGGGGGTGACGCGAC
Downstream 100 bases:
>100_bases TGGCGAAGAACCCAAAGGACGGGGAATCCCGGACGTTTTTGATCTCGGTAGCCGCCGAGCTAGCCGGCATGCATGCACAG ACCCTGCGTACCTACGATCG
Product: chaperone protein DnaJ
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 395; Mature: 394
Protein sequence:
>395_residues MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAG GGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDG TVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
Sequences:
>Translated_395_residues MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAG GGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDG TVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR >Mature_394_residues AQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGG GFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEA AKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTTR TRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGT VGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon
COG id: COG0484
COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 J domain
Homologues:
Organism=Homo sapiens, GI205360838, Length=376, Percent_Identity=33.5106382978723, Blast_Score=198, Evalue=6e-51, Organism=Homo sapiens, GI205360840, Length=376, Percent_Identity=33.5106382978723, Blast_Score=198, Evalue=9e-51, Organism=Homo sapiens, GI194328758, Length=367, Percent_Identity=30.5177111716621, Blast_Score=155, Evalue=6e-38, Organism=Homo sapiens, GI194328760, Length=367, Percent_Identity=30.5177111716621, Blast_Score=155, Evalue=7e-38, Organism=Homo sapiens, GI4504511, Length=369, Percent_Identity=29.5392953929539, Blast_Score=141, Evalue=1e-33, Organism=Homo sapiens, GI5031741, Length=367, Percent_Identity=30.2452316076294, Blast_Score=135, Evalue=6e-32, Organism=Homo sapiens, GI7706495, Length=377, Percent_Identity=29.4429708222812, Blast_Score=125, Evalue=7e-29, Organism=Homo sapiens, GI194328762, Length=333, Percent_Identity=27.027027027027, Blast_Score=114, Evalue=1e-25, Organism=Homo sapiens, GI68077168, Length=103, Percent_Identity=44.6601941747573, Blast_Score=79, Evalue=7e-15, Organism=Homo sapiens, GI68077166, Length=103, Percent_Identity=44.6601941747573, Blast_Score=79, Evalue=7e-15, Organism=Homo sapiens, GI4885495, Length=65, Percent_Identity=58.4615384615385, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI29126218, Length=84, Percent_Identity=44.047619047619, Blast_Score=77, Evalue=4e-14, Organism=Homo sapiens, GI23503241, Length=64, Percent_Identity=57.8125, Blast_Score=76, Evalue=7e-14, Organism=Homo sapiens, GI17388799, Length=65, Percent_Identity=58.4615384615385, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI194306642, Length=108, Percent_Identity=43.5185185185185, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI194306640, Length=108, Percent_Identity=43.5185185185185, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI45504382, Length=84, Percent_Identity=39.2857142857143, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI201862587, Length=65, Percent_Identity=53.8461538461538, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI201862518, Length=65, Percent_Identity=53.8461538461538, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI56549115, Length=65, Percent_Identity=53.8461538461538, Blast_Score=74, Evalue=3e-13, Organism=Homo sapiens, GI5453690, Length=64, Percent_Identity=56.25, Blast_Score=73, Evalue=5e-13, Organism=Homo sapiens, GI6631085, Length=65, Percent_Identity=55.3846153846154, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI24308127, Length=132, Percent_Identity=34.0909090909091, Blast_Score=72, Evalue=1e-12, Organism=Homo sapiens, GI47777312, Length=89, Percent_Identity=50.561797752809, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI72534740, Length=66, Percent_Identity=51.5151515151515, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI8922563, Length=87, Percent_Identity=37.9310344827586, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI22749377, Length=65, Percent_Identity=55.3846153846154, Blast_Score=70, Evalue=4e-12, Organism=Homo sapiens, GI21553335, Length=65, Percent_Identity=52.3076923076923, Blast_Score=69, Evalue=6e-12, Organism=Escherichia coli, GI1786197, Length=370, Percent_Identity=42.4324324324324, Blast_Score=281, Evalue=7e-77, Organism=Escherichia coli, GI1787235, Length=390, Percent_Identity=33.5897435897436, Blast_Score=172, Evalue=4e-44, Organism=Caenorhabditis elegans, GI17553096, Length=383, Percent_Identity=30.2872062663185, Blast_Score=183, Evalue=1e-46, Organism=Caenorhabditis elegans, GI17553098, Length=383, Percent_Identity=30.5483028720627, Blast_Score=183, Evalue=2e-46, Organism=Caenorhabditis elegans, GI17507263, Length=374, Percent_Identity=31.283422459893, Blast_Score=127, Evalue=7e-30, Organism=Caenorhabditis elegans, GI17554644, Length=136, Percent_Identity=41.1764705882353, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17563890, Length=200, Percent_Identity=30, Blast_Score=78, Evalue=8e-15, Organism=Caenorhabditis elegans, GI212645553, Length=64, Percent_Identity=51.5625, Blast_Score=75, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17534355, Length=65, Percent_Identity=49.2307692307692, Blast_Score=68, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17538236, Length=130, Percent_Identity=37.6923076923077, Blast_Score=68, Evalue=1e-11, Organism=Caenorhabditis elegans, GI115532378, Length=157, Percent_Identity=26.7515923566879, Blast_Score=67, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324265, Length=367, Percent_Identity=32.425068119891, Blast_Score=169, Evalue=1e-42, Organism=Saccharomyces cerevisiae, GI6321094, Length=395, Percent_Identity=32.9113924050633, Blast_Score=139, Evalue=1e-33, Organism=Saccharomyces cerevisiae, GI6323870, Length=369, Percent_Identity=31.7073170731707, Blast_Score=134, Evalue=2e-32, Organism=Saccharomyces cerevisiae, GI6323119, Length=391, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=1e-23, Organism=Saccharomyces cerevisiae, GI6324252, Length=446, Percent_Identity=23.3183856502242, Blast_Score=81, Evalue=3e-16, Organism=Saccharomyces cerevisiae, GI6322194, Length=98, Percent_Identity=45.9183673469388, Blast_Score=78, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6320888, Length=115, Percent_Identity=38.2608695652174, Blast_Score=74, Evalue=3e-14, Organism=Saccharomyces cerevisiae, GI6323813, Length=140, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=6e-14, Organism=Drosophila melanogaster, GI45552813, Length=390, Percent_Identity=32.5641025641026, Blast_Score=178, Evalue=5e-45, Organism=Drosophila melanogaster, GI45549272, Length=390, Percent_Identity=32.5641025641026, Blast_Score=178, Evalue=5e-45, Organism=Drosophila melanogaster, GI45552811, Length=390, Percent_Identity=32.8205128205128, Blast_Score=177, Evalue=1e-44, Organism=Drosophila melanogaster, GI24646562, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28, Organism=Drosophila melanogaster, GI24646560, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28, Organism=Drosophila melanogaster, GI24646558, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28, Organism=Drosophila melanogaster, GI24646556, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28, Organism=Drosophila melanogaster, GI21357547, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28, Organism=Drosophila melanogaster, GI20129487, Length=376, Percent_Identity=29.5212765957447, Blast_Score=122, Evalue=4e-28, Organism=Drosophila melanogaster, GI24584014, Length=376, Percent_Identity=29.5212765957447, Blast_Score=122, Evalue=4e-28, Organism=Drosophila melanogaster, GI28574949, Length=378, Percent_Identity=26.1904761904762, Blast_Score=117, Evalue=1e-26, Organism=Drosophila melanogaster, GI19920464, Length=149, Percent_Identity=32.8859060402685, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI24658562, Length=64, Percent_Identity=56.25, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24658555, Length=64, Percent_Identity=56.25, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24654066, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24654070, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24654068, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24654072, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI24645889, Length=89, Percent_Identity=37.0786516853933, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24641698, Length=125, Percent_Identity=33.6, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24641696, Length=125, Percent_Identity=33.6, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI161077138, Length=64, Percent_Identity=53.125, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI17737735, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI28574723, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI21358273, Length=64, Percent_Identity=56.25, Blast_Score=69, Evalue=6e-12, Organism=Drosophila melanogaster, GI24668523, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=6e-12, Organism=Drosophila melanogaster, GI85726398, Length=65, Percent_Identity=50.7692307692308, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): DNAJ1_MYCBO (P0A549)
Other databases:
- EMBL: BX248335 - RefSeq: NP_854023.1 - ProteinModelPortal: P0A549 - EnsemblBacteria: EBMYCT00000017308 - GeneID: 1091255 - GenomeReviews: BX248333_GR - KEGG: mbo:Mb0360 - GeneTree: EBGT00050000015762 - HOGENOM: HBG635315 - OMA: ENHPDRN - ProtClustDB: PRK14279 - BioCyc: MBOV233413:MB0360-MONOMER - GO: GO:0005737 - HAMAP: MF_01152 - InterPro: IPR012724 - InterPro: IPR002939 - InterPro: IPR001623 - InterPro: IPR018253 - InterPro: IPR008971 - InterPro: IPR015609 - InterPro: IPR003095 - InterPro: IPR001305 - Gene3D: G3DSA:1.10.287.110 - Gene3D: G3DSA:2.10.230.10 - PANTHER: PTHR11821 - PRINTS: PR00625 - SMART: SM00271 - TIGRFAMs: TIGR02349
Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG; SSF46565 DnaJ_N; SSF49493 HSP40_DnaJ_pep; SSF57938 HSP_DnaJ_cys-rich
EC number: NA
Molecular weight: Translated: 41345; Mature: 41214
Theoretical pI: Translated: 8.21; Mature: 8.21
Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2; PS51188 ZF_CR; PS00637 DNAJ_CXXCXGXG
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.0 %Cys (Translated Protein) 0.5 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 2.0 %Cys (Mature Protein) 0.3 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHN CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH VLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRT HHCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC GGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNC CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC HGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTV EEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCEECCCCCCEEEEE PVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVA ECCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEE VPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC >Mature Secondary Structure AQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHN CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH VLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRT HHCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC GGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNC CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC HGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRDGDDLTVTV EEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCEECCCCCCEEEEE PVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVA ECCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEE VPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972