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The map label for this gene is iniA

Identifier: 148660108

GI number: 148660108

Start: 412200

End: 414122

Strand: Direct

Name: iniA

Synonym: MRA_0351

Alternate gene names: 148660108

Gene position: 412200-414122 (Clockwise)

Preceding gene: 148660107

Following gene: 148660109

Centisome position: 9.33

GC content: 63.49

Gene sequence:

>1923_bases
ATGGTCCCCGCCGGTTTGTGCGCATACCGTGATCTGAGGCGTAAACGAGCGAGAAAGTGGGGCGACACGGTGACCCAGCC
CGATGACCCACGTCGGGTCGGTGTGATCGTCGAACTGATCGATCACACTATCGCCATCGCCAAACTGAACGAGCGTGGTG
ATCTAGTACAGCGGTTGACGCGGGCTCGCCAGCGGATCACCGACCCGCAGGTCCGTGTGGTGATCGCCGGGCTGCTCAAA
CAGGGCAAGAGTCAATTGCTCAATTCGTTGCTCAACCTGCCCGCGGCGCGAGTAGGCGATGACGAGGCCACCGTGGTGAT
CACCGTCGTAAGCTACAGCGCCCAACCGTCGGCCCGGCTTGTGCTGGCCGCCGGGCCCGACGGGACAACCGCAGCGGTTG
ACATTCCCGTCGATGACATCAGCACCGATGTGCGTCGGGCTCCGCACGCCGGTGGCCGCGAGGTGTTGCGGGTCGAGGTC
GGCGCGCCCAGCCCGCTGCTGCGGGGCGGGCTGGCGTTTATCGATACTCCGGGTGTGGGCGGCCTCGGACAGCCCCACCT
GTCGGCGACGCTGGGGCTGCTACCCGAGGCCGATGCCGTCTTGGTGGTCAGCGACACCAGCCAGGAATTCACCGAACCCG
AGATGTGGTTCGTGCGGCAGGCCCACCAGATCTGTCCGGTCGGGGCGGTCGTGGCCACCAAGACCGACCTGTATCCGCGC
TGGCGGGAGATCGTCAATGCCAATGCAGCACATCTGCAGCGGGCCCGGGTTCCGATGCCGATCATCGCAGTCTCATCACT
GTTGCGCAGCCACGCGGTCACGCTTAACGACAAAGAGCTCAACGAAGAGTCCAACTTTCCGGCGATCGTCAAGTTTCTCA
GCGAGCAGGTGCTTTCCCGCGCGACGGAGCGAGTGCGTGCTGGGGTACTCGGCGAAATACGTTCGGCAACAGAGCAATTG
GCGGTGTCTCTAGGTTCCGAACTATCGGTGGTCAACGACCCGAACCTCCGTGACCGACTTGCTTCGGATTTGGAGCGGCG
CAAACGGGAAGCCCAGCAGGCGGTGCAACAGACAGCGCTGTGGCAGCAGGTGCTGGGCGACGGGTTCAACGACCTGACTG
CTGACGTGGACCACGACCTACGAACCCGCTTCCGCACCGTCACCGAAGACGCCGAGCGCCAGATCGACTCCTGTGACCCG
ACTGCGCATTGGGCCGAGATTGGCAACGACGTCGAGAATGCGATCGCCACAGCGGTCGGCGACAACTTCGTGTGGGCATA
CCAGCGTTCCGAAGCGTTGGCCGACGACGTCGCTCGCTCCTTTGCCGACGCGGGGTTGGACTCGGTCCTGTCAGCAGAGC
TGAGCCCCCACGTCATGGGCACCGACTTCGGCCGGCTCAAAGCGCTGGGCCGGATGGAATCGAAACCGCTGCGCCGGGGC
CATAAAATGATTATCGGCATGCGGGGTTCCTATGGCGGCGTGGTCATGATTGGCATGCTGTCGTCGGTGGTCGGACTTGG
GTTGTTCAACCCGCTATCGGTGGGGGCCGGGTTGATCCTCGGCCGGATGGCATATAAAGAGGACAAACAAAACCGGTTGC
TGCGGGTGCGCAGCGAGGCCAAGGCCAATGTGCGGCGCTTCGTCGACGACATTTCGTTCGTCGTCAGCAAACAATCACGG
GATCGGCTCAAGATGATCCAGCGTCTGCTGCGCGACCACTACCGCGAGATCGCCGAAGAGATCACCCGGTCGCTCACCGA
GTCCCTGCAGGCGACCATCGCGGCGGCGCAGGTGGCGGAAACCGAGCGGGACAATCGAATTCGGGAACTTCAGCGGCAAT
TGGGTATCCTGAGCCAGGTCAACGACAACCTTGCCGGCTTGGAGCCAACCTTGACGCCCCGGGCGAGCTTGGGACGAGCG
TGA

Upstream 100 bases:

>100_bases
GCACACGCCGCCGGCGCCCATCGAACTGCCGTCGTACGGCCTTTTCGGACTACCCGGGTTCTGATTCGCGAGCCGATTTC
ACGAACCGGTGGGGACGTTC

Downstream 100 bases:

>100_bases
GCACCAGCGACCGGGTCCGCGCGATTCTGCACGCAACCATCCAGGCCTACCGGGGTGCGCCGGCCTATCGTCAGCGTGGC
GACGTTTTTTGCCAGCTGGA

Product: isoniazid inductible gene protein IniA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLK
QGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEV
GAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQL
AVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDP
TAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSR
DRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA

Sequences:

>Translated_640_residues
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLK
QGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEV
GAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQL
AVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDP
TAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSR
DRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA
>Mature_640_residues
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLK
QGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEV
GAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQL
AVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDP
TAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSR
DRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA

Specific function: Participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell

COG id: COG0699

COG function: function code R; Predicted GTPases (dynamin-related)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): INIA_MYCTU (O06293)

Other databases:

- EMBL:   BX842573
- EMBL:   AE000516
- PIR:   G70573
- RefSeq:   NP_214856.1
- RefSeq:   NP_334765.1
- ProteinModelPortal:   O06293
- EnsemblBacteria:   EBMYCT00000000711
- EnsemblBacteria:   EBMYCT00000070315
- GeneID:   886510
- GeneID:   923505
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0357
- KEGG:   mtu:Rv0342
- TIGR:   MT0357
- TubercuList:   Rv0342
- GeneTree:   EBGT00050000017104
- HOGENOM:   HBG322664
- OMA:   VGMRGSY
- ProtClustDB:   CLSK871791
- InterPro:   IPR001401

Pfam domain/function: PF00350 Dynamin_N

EC number: NA

Molecular weight: Translated: 70084; Mature: 70084

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1af95ba4)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLT
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECHHHHHHHHHH
RARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEE
VLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVG
EEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCEEEEECCCCC
GLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
CCCCCHHHHHHCCCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHCCCCHHHHCCCCCCHH
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSR
HHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHH
ATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVG
HHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHC
DNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
CCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHCC
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEA
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLT
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECHHHHHHHHHH
RARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEE
VLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVG
EEEECCCCCEEEEECCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCEEEEECCCCC
GLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
CCCCCHHHHHHCCCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHCCCCHHHHCCCCCCHH
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSR
HHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHH
ATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVG
HHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHC
DNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
CCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHCC
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEA
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036