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The map label for this gene is hisI [H]

Identifier: 148654116

GI number: 148654116

Start: 2886828

End: 2887757

Strand: Direct

Name: hisI [H]

Synonym: PsycPRwf_2319

Alternate gene names: 148654116

Gene position: 2886828-2887757 (Clockwise)

Preceding gene: 148654110

Following gene: 148654117

Centisome position: 96.91

GC content: 48.92

Gene sequence:

>930_bases
ATGTCCTCTCACAATACGCAAACTGCCAAGCCACAACAGATGACAGATGCCAATACCGCTTGGTTAGAACAAGTAACTTT
TACCGCTGATGGCCTCATTCCCGCCATTGCACAAGACAAAGACAGCGGCGAAATCCTAATGATGGCTTGGATGAATAAAG
AGGCATTGCATCTGACTGCGCAGACCAAAACTGCCGTGTATTTTTCACGCTCGCGCGGTAAGCTGTGGCACAAGGGGGAG
AGCTCAGGGCACACTCAAATTGTGCATGACATTCATCTAGATTGTGACGCGGATGTGATTGTACTGACCGTGACCCAAAT
TGGGGATATTGCTTGTCACACAGGACGCAGATCGTGCTTTTATCGTAAGCTTGACCTATCCGGTGGGGCGCCAAGTTGGC
AGACCGTCGCTCCGGTATTAAAAGATCCTGACGCCATCTATGGCACTACTGCATCTGAGTCTGCCAATGATATAATAGCG
GCTCAGCATACTGCTCAAGATGACAGTACTGACACCTATGCGCAGCCAGCATCACAGACACAAGCTCACAGCGTATTACA
ACAGCTAGATGCGGTATTAGTGGCGCGCAAAAAGGCCGATGCCAACAGCTCTTATGTGGCAAGCCTTTATGCCAAAGGTC
TTAATAAGATTTTGGAAAAAGTAGGTGAAGAAGCAGTAGAGAGCATTATTGCGGCCAAAGACTTGGCTGCGCTAAGCCAG
GTGTCTGCACCTAATACCCAAAACTCTGAGCCGCTAGATGAGGTACAGCAAGCCTTAAGCGATGATTTGATCTATGAGAT
TGCTGATGTGTGGTTTCACACTTTGGTCACATTGGCATGGTTTAATATCGGGTCCGATCGCATACTGGCTGAGTTGGCGC
GCCGCTTTGGCCTCTCAGGCATCGAAGAGAAAAATAGCCGCCCCCATTAA

Upstream 100 bases:

>100_bases
GTTAAGCCTTTGATACGACTTGGCCGCCTGCTACCCTAGCATACCTTGAGCAGCAAAGACGTCAAGACAACTCATTTAAC
CAGATACAATAGGGTGCTTT

Downstream 100 bases:

>100_bases
GAGTTAAGTTAATATCTTTATCCCTTTTTTCTACCCTTGCTCGACACGTATAGCCATTTATAACACGGCGATTAAGGCAA
ACCATTAAGTTAAACCACTG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSSHNTQTAKPQQMTDANTAWLEQVTFTADGLIPAIAQDKDSGEILMMAWMNKEALHLTAQTKTAVYFSRSRGKLWHKGE
SSGHTQIVHDIHLDCDADVIVLTVTQIGDIACHTGRRSCFYRKLDLSGGAPSWQTVAPVLKDPDAIYGTTASESANDIIA
AQHTAQDDSTDTYAQPASQTQAHSVLQQLDAVLVARKKADANSSYVASLYAKGLNKILEKVGEEAVESIIAAKDLAALSQ
VSAPNTQNSEPLDEVQQALSDDLIYEIADVWFHTLVTLAWFNIGSDRILAELARRFGLSGIEEKNSRPH

Sequences:

>Translated_309_residues
MSSHNTQTAKPQQMTDANTAWLEQVTFTADGLIPAIAQDKDSGEILMMAWMNKEALHLTAQTKTAVYFSRSRGKLWHKGE
SSGHTQIVHDIHLDCDADVIVLTVTQIGDIACHTGRRSCFYRKLDLSGGAPSWQTVAPVLKDPDAIYGTTASESANDIIA
AQHTAQDDSTDTYAQPASQTQAHSVLQQLDAVLVARKKADANSSYVASLYAKGLNKILEKVGEEAVESIIAAKDLAALSQ
VSAPNTQNSEPLDEVQQALSDDLIYEIADVWFHTLVTLAWFNIGSDRILAELARRFGLSGIEEKNSRPH
>Mature_308_residues
SSHNTQTAKPQQMTDANTAWLEQVTFTADGLIPAIAQDKDSGEILMMAWMNKEALHLTAQTKTAVYFSRSRGKLWHKGES
SGHTQIVHDIHLDCDADVIVLTVTQIGDIACHTGRRSCFYRKLDLSGGAPSWQTVAPVLKDPDAIYGTTASESANDIIAA
QHTAQDDSTDTYAQPASQTQAHSVLQQLDAVLVARKKADANSSYVASLYAKGLNKILEKVGEEAVESIIAAKDLAALSQV
SAPNTQNSEPLDEVQQALSDDLIYEIADVWFHTLVTLAWFNIGSDRILAELARRFGLSGIEEKNSRPH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=45.0549450549451, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 33674; Mature: 33543

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHNTQTAKPQQMTDANTAWLEQVTFTADGLIPAIAQDKDSGEILMMAWMNKEALHLTA
CCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCEEEEEE
QTKTAVYFSRSRGKLWHKGESSGHTQIVHDIHLDCDADVIVLTVTQIGDIACHTGRRSCF
CCCEEEEEECCCCCEEECCCCCCCEEEEEEEECCCCCCEEEEEECHHCCHHHCCCCCHHE
YRKLDLSGGAPSWQTVAPVLKDPDAIYGTTASESANDIIAAQHTAQDDSTDTYAQPASQT
EEEEECCCCCCCHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHH
QAHSVLQQLDAVLVARKKADANSSYVASLYAKGLNKILEKVGEEAVESIIAAKDLAALSQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAPNTQNSEPLDEVQQALSDDLIYEIADVWFHTLVTLAWFNIGSDRILAELARRFGLSG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
IEEKNSRPH
CCCCCCCCC
>Mature Secondary Structure 
SSHNTQTAKPQQMTDANTAWLEQVTFTADGLIPAIAQDKDSGEILMMAWMNKEALHLTA
CCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCEEEEEE
QTKTAVYFSRSRGKLWHKGESSGHTQIVHDIHLDCDADVIVLTVTQIGDIACHTGRRSCF
CCCEEEEEECCCCCEEECCCCCCCEEEEEEEECCCCCCEEEEEECHHCCHHHCCCCCHHE
YRKLDLSGGAPSWQTVAPVLKDPDAIYGTTASESANDIIAAQHTAQDDSTDTYAQPASQT
EEEEECCCCCCCHHHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHH
QAHSVLQQLDAVLVARKKADANSSYVASLYAKGLNKILEKVGEEAVESIIAAKDLAALSQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAPNTQNSEPLDEVQQALSDDLIYEIADVWFHTLVTLAWFNIGSDRILAELARRFGLSG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
IEEKNSRPH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500908 [H]