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The map label for this gene is parC [H]

Identifier: 148653991

GI number: 148653991

Start: 2732430

End: 2734718

Strand: Direct

Name: parC [H]

Synonym: PsycPRwf_2194

Alternate gene names: 148653991

Gene position: 2732430-2734718 (Clockwise)

Preceding gene: 148653985

Following gene: 148653992

Centisome position: 91.72

GC content: 48.67

Gene sequence:

>2289_bases
ATGTCTGATATTACAACTCCCGCGTCTGTAATTCCAAACGAAGCGATGGATACCCGCTCTGTGGCTGAATTCACCGAGCA
AGCTTATCTTAACTACGCCATGTACGTGATTATGGATCGTGCGCTGCCACACATCGCTGATGGTCTAAAGCCGGTGCAAC
GCCGTATTATCTACGCCATGAGCGAGCTTGGACTTAAGTCTACGACCAAACCCAAAAAATCTGCACGTACAGTTGGTGAT
GTGTTAGGTAAATACCATCCTCATGGTGACACGGCCTGTTATGAAGCCATGGTATTGATGGCTCAGCCGTTTAGTTATCG
CTATCCACTGATCAGCGGTCAAGGCAACTGGGGTAGTCCAGATGACCCAAAATCCTTTGCTGCGATGCGTTATACCGAGG
CCAAAATGTCAGCCTATGCCAACACCTTATTGGCTGAGCTGGGGCAAGGCACAGTCGACTGGCAGGACAACTTCGACGGT
TCGATGCAAGAGCCGGTCACCTTACCTGCCCGCTTGCCCAACATCTTATTAAATGGCACCACAGGTATCGCTGTGGGTAT
GGCAACGGATATCCCGCCGCACAACTTAAATGAAGTGGTGCGTGCCGCCATTCGGCTGCTAAAAAACCCCGATTTATCGG
TCAAGCAATTAACCCAGTCTATTCCTGCACCCGACCTGCCCACTGCTGCTGAGATCATCACCTCTAAAAAAGACTTACAG
GCGATGTATGAAACAGGGCGCGGTAGCTATAAGATGCGCGCGGTTTATCATGTCGATCAACAAGAGAAAAATCTGGTCAT
TATCGATGCCTTGCCGTATCAAGTCTCAGGCAATAAAGTACAAGAACAAATTGCCAAGCTTATGATGGATAAGAAGCTGC
CATGGGTGGTGGATATCCATGACGAATCAGACCACGAAAACGCTTGCCGTATTGTGCTTGAGCTGCGCTCTACTCGTGTC
GATGTGGCGCGCGTGATGAGCCATTTATTTGCCAGTACTGACCTTGAGAGCAGCTACCGGGTCAATATGAACATGATTGG
CTTAAATGGTAAACCGCAGGTCAAAAACCTCAAAGAAGTGCTAGAGGAATGGCTGATCAGCCGCCGCCAAGTGGTTACTC
GCCGGGTACAATTTAGATTGGATAAAATTGACAAGCGCTTACACATTTTAGCTGGTCTACTTATCGCCTATCTTAATATC
GATGAGGTGATTCGCATCATTCGTGAAGAAGACGACCCCAAACAAGAGCTAATGGGCAAATATGACCTCAGTGACATCCA
AGCCAATGCCATTTTAGACATTCGTCTACGTCAATTAGCACGCTTAGAGGAGATTGAACTTCGCTCTGAAAAGGACGCAT
TAGAGGCTGAGCGTGCCACGCTACAAGAGCTATTAGATAATCCTGAGAGCTTAACTCAGCTTATGATTGAAGAGCTTGAA
GCGGATATGAAAGAGCATGGCAATGATCGTATGTCCTCTGTGGTTGAGCGTGAGGAAGCCACCGCATTAAAAGAGTCTGA
CTTGGTGCCAAGCGAGCCGATTACCGCCGTATTGTCTAAAGCAGGTTGGATTCGTGCTGCCAAAGGTCACGACGTTGATG
CTAAAGGCATGAGCTACCGCTCAGGTGACAGCTATCAAGCGCATGTGCACAGCAAATCCAATGAGAAGATTTATATCATG
GACAGTACCGGTCGCAGCTATAGTATAGAGGCACATACCCTAGCCTCGGCGCGAGGTCAAGGTGACCCACTCACCAGCGT
GTTAAAACCGCCTGCCGGTGCCAGCTTCGAGCAGCTGTTGGCCGGTGCTGATGATCAGCGCATTATCCTTGCCAGCTCAC
AAGGCTATGGCTTTATTAATACCCTAGGCAATCTTGAGACCAATCAAAAAGCGGGTAAAAATGTCATTAACTTTGATGCC
GATGCTAAGCTGTTAACGGTTGCAACCATTGATAAAACAGACTCAGAGACGCCAGATGACGCACAGGCGTTAACTCAAAA
CCAAATCGCTGTGGTGACGTCAGCGGGCTATTTGCTTATCTTTGGGGTCGATGAACTGCCCGAGCAGCAGCGTGGCAAAG
GCAATAAGCTGATTAACCTAAAGGCAGGCGAGGAAGTATTGGCCGTGATTGCTTTAAACAGCCATGACAGCTTAACCATC
ACCGCCGGCAAACGCCATGTAACACTAAAACCGATGGACTTGGCCAATTACACCAGCAAACGTGGCAACCGTGGCGGTCA
ATTACCGCGTGGTTTTCAGAATGTGACCCAAATCGAAGTGACTCAATAG

Upstream 100 bases:

>100_bases
ATAGGCAACCTTAAACTTAAAGGTTTAATGTCTATAATCGAAACCATGACCCCCTTTGTTCTTAAAAACTTTTATATGAA
ATAAGGCAGAAGCTTTTATT

Downstream 100 bases:

>100_bases
CTTGTGACAGCAGCTATTTTATAAGGACATACCCCCTAACTAAGGACACAACCATGGTTTTTCAGACTTTATTTAACCGG
GCATTTAGCGCTCACAGCGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MSDITTPASVIPNEAMDTRSVAEFTEQAYLNYAMYVIMDRALPHIADGLKPVQRRIIYAMSELGLKSTTKPKKSARTVGD
VLGKYHPHGDTACYEAMVLMAQPFSYRYPLISGQGNWGSPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDG
SMQEPVTLPARLPNILLNGTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPDLSVKQLTQSIPAPDLPTAAEIITSKKDLQ
AMYETGRGSYKMRAVYHVDQQEKNLVIIDALPYQVSGNKVQEQIAKLMMDKKLPWVVDIHDESDHENACRIVLELRSTRV
DVARVMSHLFASTDLESSYRVNMNMIGLNGKPQVKNLKEVLEEWLISRRQVVTRRVQFRLDKIDKRLHILAGLLIAYLNI
DEVIRIIREEDDPKQELMGKYDLSDIQANAILDIRLRQLARLEEIELRSEKDALEAERATLQELLDNPESLTQLMIEELE
ADMKEHGNDRMSSVVEREEATALKESDLVPSEPITAVLSKAGWIRAAKGHDVDAKGMSYRSGDSYQAHVHSKSNEKIYIM
DSTGRSYSIEAHTLASARGQGDPLTSVLKPPAGASFEQLLAGADDQRIILASSQGYGFINTLGNLETNQKAGKNVINFDA
DAKLLTVATIDKTDSETPDDAQALTQNQIAVVTSAGYLLIFGVDELPEQQRGKGNKLINLKAGEEVLAVIALNSHDSLTI
TAGKRHVTLKPMDLANYTSKRGNRGGQLPRGFQNVTQIEVTQ

Sequences:

>Translated_762_residues
MSDITTPASVIPNEAMDTRSVAEFTEQAYLNYAMYVIMDRALPHIADGLKPVQRRIIYAMSELGLKSTTKPKKSARTVGD
VLGKYHPHGDTACYEAMVLMAQPFSYRYPLISGQGNWGSPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDG
SMQEPVTLPARLPNILLNGTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPDLSVKQLTQSIPAPDLPTAAEIITSKKDLQ
AMYETGRGSYKMRAVYHVDQQEKNLVIIDALPYQVSGNKVQEQIAKLMMDKKLPWVVDIHDESDHENACRIVLELRSTRV
DVARVMSHLFASTDLESSYRVNMNMIGLNGKPQVKNLKEVLEEWLISRRQVVTRRVQFRLDKIDKRLHILAGLLIAYLNI
DEVIRIIREEDDPKQELMGKYDLSDIQANAILDIRLRQLARLEEIELRSEKDALEAERATLQELLDNPESLTQLMIEELE
ADMKEHGNDRMSSVVEREEATALKESDLVPSEPITAVLSKAGWIRAAKGHDVDAKGMSYRSGDSYQAHVHSKSNEKIYIM
DSTGRSYSIEAHTLASARGQGDPLTSVLKPPAGASFEQLLAGADDQRIILASSQGYGFINTLGNLETNQKAGKNVINFDA
DAKLLTVATIDKTDSETPDDAQALTQNQIAVVTSAGYLLIFGVDELPEQQRGKGNKLINLKAGEEVLAVIALNSHDSLTI
TAGKRHVTLKPMDLANYTSKRGNRGGQLPRGFQNVTQIEVTQ
>Mature_761_residues
SDITTPASVIPNEAMDTRSVAEFTEQAYLNYAMYVIMDRALPHIADGLKPVQRRIIYAMSELGLKSTTKPKKSARTVGDV
LGKYHPHGDTACYEAMVLMAQPFSYRYPLISGQGNWGSPDDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDGS
MQEPVTLPARLPNILLNGTTGIAVGMATDIPPHNLNEVVRAAIRLLKNPDLSVKQLTQSIPAPDLPTAAEIITSKKDLQA
MYETGRGSYKMRAVYHVDQQEKNLVIIDALPYQVSGNKVQEQIAKLMMDKKLPWVVDIHDESDHENACRIVLELRSTRVD
VARVMSHLFASTDLESSYRVNMNMIGLNGKPQVKNLKEVLEEWLISRRQVVTRRVQFRLDKIDKRLHILAGLLIAYLNID
EVIRIIREEDDPKQELMGKYDLSDIQANAILDIRLRQLARLEEIELRSEKDALEAERATLQELLDNPESLTQLMIEELEA
DMKEHGNDRMSSVVEREEATALKESDLVPSEPITAVLSKAGWIRAAKGHDVDAKGMSYRSGDSYQAHVHSKSNEKIYIMD
STGRSYSIEAHTLASARGQGDPLTSVLKPPAGASFEQLLAGADDQRIILASSQGYGFINTLGNLETNQKAGKNVINFDAD
AKLLTVATIDKTDSETPDDAQALTQNQIAVVTSAGYLLIFGVDELPEQQRGKGNKLINLKAGEEVLAVIALNSHDSLTIT
AGKRHVTLKPMDLANYTSKRGNRGGQLPRGFQNVTQIEVTQ

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=408, Percent_Identity=22.7941176470588, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1789396, Length=747, Percent_Identity=56.6265060240964, Blast_Score=872, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=620, Percent_Identity=37.741935483871, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=382, Percent_Identity=23.2984293193717, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=358, Percent_Identity=23.7430167597765, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=211, Percent_Identity=25.1184834123223, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84446; Mature: 84315

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDITTPASVIPNEAMDTRSVAEFTEQAYLNYAMYVIMDRALPHIADGLKPVQRRIIYAM
CCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SELGLKSTTKPKKSARTVGDVLGKYHPHGDTACYEAMVLMAQPFSYRYPLISGQGNWGSP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCC
DDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDGSMQEPVTLPARLPNILLNGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECC
TGIAVGMATDIPPHNLNEVVRAAIRLLKNPDLSVKQLTQSIPAPDLPTAAEIITSKKDLQ
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHCHHHHH
AMYETGRGSYKMRAVYHVDQQEKNLVIIDALPYQVSGNKVQEQIAKLMMDKKLPWVVDIH
HHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
DESDHENACRIVLELRSTRVDVARVMSHLFASTDLESSYRVNMNMIGLNGKPQVKNLKEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHH
LEEWLISRRQVVTRRVQFRLDKIDKRLHILAGLLIAYLNIDEVIRIIREEDDPKQELMGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHCCC
YDLSDIQANAILDIRLRQLARLEEIELRSEKDALEAERATLQELLDNPESLTQLMIEELE
CCCCHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ADMKEHGNDRMSSVVEREEATALKESDLVPSEPITAVLSKAGWIRAAKGHDVDAKGMSYR
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCC
SGDSYQAHVHSKSNEKIYIMDSTGRSYSIEAHTLASARGQGDPLTSVLKPPAGASFEQLL
CCCCEEEEEECCCCCEEEEEECCCCEEEEEHHHHHHCCCCCCCHHHHHCCCCCCCHHHHH
AGADDQRIILASSQGYGFINTLGNLETNQKAGKNVINFDADAKLLTVATIDKTDSETPDD
CCCCCCEEEEECCCCCEEHHHHCCCCCCHHHCCCEEEECCCCEEEEEEEECCCCCCCCCH
AQALTQNQIAVVTSAGYLLIFGVDELPEQQRGKGNKLINLKAGEEVLAVIALNSHDSLTI
HHHHCCCCEEEEEECCEEEEECCHHCCHHHCCCCCEEEEEECCCEEEEEEEECCCCCEEE
TAGKRHVTLKPMDLANYTSKRGNRGGQLPRGFQNVTQIEVTQ
EECCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SDITTPASVIPNEAMDTRSVAEFTEQAYLNYAMYVIMDRALPHIADGLKPVQRRIIYAM
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SELGLKSTTKPKKSARTVGDVLGKYHPHGDTACYEAMVLMAQPFSYRYPLISGQGNWGSP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCC
DDPKSFAAMRYTEAKMSAYANTLLAELGQGTVDWQDNFDGSMQEPVTLPARLPNILLNGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECC
TGIAVGMATDIPPHNLNEVVRAAIRLLKNPDLSVKQLTQSIPAPDLPTAAEIITSKKDLQ
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHCHHHHH
AMYETGRGSYKMRAVYHVDQQEKNLVIIDALPYQVSGNKVQEQIAKLMMDKKLPWVVDIH
HHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
DESDHENACRIVLELRSTRVDVARVMSHLFASTDLESSYRVNMNMIGLNGKPQVKNLKEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHH
LEEWLISRRQVVTRRVQFRLDKIDKRLHILAGLLIAYLNIDEVIRIIREEDDPKQELMGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHCCC
YDLSDIQANAILDIRLRQLARLEEIELRSEKDALEAERATLQELLDNPESLTQLMIEELE
CCCCHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ADMKEHGNDRMSSVVEREEATALKESDLVPSEPITAVLSKAGWIRAAKGHDVDAKGMSYR
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCC
SGDSYQAHVHSKSNEKIYIMDSTGRSYSIEAHTLASARGQGDPLTSVLKPPAGASFEQLL
CCCCEEEEEECCCCCEEEEEECCCCEEEEEHHHHHHCCCCCCCHHHHHCCCCCCCHHHHH
AGADDQRIILASSQGYGFINTLGNLETNQKAGKNVINFDADAKLLTVATIDKTDSETPDD
CCCCCCEEEEECCCCCEEHHHHCCCCCCHHHCCCEEEECCCCEEEEEEEECCCCCCCCCH
AQALTQNQIAVVTSAGYLLIFGVDELPEQQRGKGNKLINLKAGEEVLAVIALNSHDSLTI
HHHHCCCCEEEEEECCEEEEECCHHCCHHHCCCCCEEEEEECCCEEEEEEEECCCCCEEE
TAGKRHVTLKPMDLANYTSKRGNRGGQLPRGFQNVTQIEVTQ
EECCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]