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The map label for this gene is thrS

Identifier: 148653933

GI number: 148653933

Start: 2666956

End: 2668890

Strand: Direct

Name: thrS

Synonym: PsycPRwf_2136

Alternate gene names: 148653933

Gene position: 2666956-2668890 (Clockwise)

Preceding gene: 148653924

Following gene: 148653934

Centisome position: 89.53

GC content: 45.17

Gene sequence:

>1935_bases
ATGGTTGCAATTACTTTACCTGATGGCAATGTAAAAGAGTTTGACGGTGCGACAACAGTGATGGAAGTGGCTCAAAGTAT
TGGCCCAGGCCTTGCTAAAGCAACAATCGCTGGACGTGTGGATGGTAAGCTTGTGGACGCAAGTGATCCGATTACCCAAG
ACGCAAGTGTTGAAATTGTGACCGCAAAAGACAAAGATGGCGTCGATATTATTCGTCACTCTACCGCACACTTACTAGGT
CATGCGGTTAAGCAGTTGTATCCTAACGTAAAAATGGTTATTGGCCCTGTTATTGAAGATGGCTTTTATTACGACATTTT
TAGTGAAAAGCCCTTTACCCCAGAGGATATGGCCGCTATTGAAAAGCGTATGGCGGAGCTGATCAAGCAAAATTACGATG
TCATTAAGAAAATGACCCCACGTGAAGAAGCGATTAAAATCTTTGAAGAGCGCGGTGAAGATTATAAGCTCAAGCTAATC
GCAGATATGCCAGAGGAAAAAGAGCTGGGTCTGTATCATCATCAAGAATATGTGGATATGTGCCGCGGCCCACACGTACC
AAACACCCGCTTCTTAAAAGTATTTAAACTGATGAAAATGAGCGGTGCGTATTGGCGCGGTGATGCCAAAAATGAGCAGC
TCCAGCGTATCTATGGTACCGCTTGGGCAGATAAAAAAGATTTACAAGCTTATATCCAGCGTATTGAAGAAGCTGAAAAG
CGTGACCACCGTAAAATTGGTAAAGCGCTGAATTTATTCCATATGCAAGAGCAGTCGCCAGGTATGGTGTTCTGGCATCC
AAATGGCTGGACCATTTATCAAGTGCTTGAGCAATACATGCGTAAAGTACAAAAAGACAATGGTTATCAAGAGATCAAGA
CACCACAGATTGTTGACAGAAGCTTGTGGGAAAAATCAGGACACTGGGGTAACTATGCGACCAATATGTTCACTACCTCG
AGTGAAAGCCGTGATTATGCAGTAAAACCGATGAACTGCCCTTGCCACGTGCAAGTATTTAACCAAGGCCTAAAGTCTTA
TCGTGAATTGCCAATTCGTTTGGCAGAATTTGGCTCTTGCCACCGTAATGAGCCTTCAGGCTCTCTACATGGCTTGATGC
GGGTACGCGGCTTTACTCAAGATGATGCTCATATCTTCTGTACCCAAGCCCAAATTCAAGAGGAAGTAGCCAACTTTATT
AAGCTAACCTTGGATGTCTATAAAGACTTTGGCTTCGACCAAATTGAGATGAAACTCTCTACTCGCCCAGAAAAACGTGT
GGGTACTGACGAATCTTGGGACATCGCCGAAAAAGCCTTGGCCGATGCGTTAGACAGCTCAGGTCTTGAGTGGGAGTATC
TGCCTGGTGAAGGCGCATTTTATGGTCCAAAAATTGAATTTAGCCTAAAAGACAGCTTAGGCCGTGTGTGGCAGTGCGGT
ACCATTCAGGTAGACCCCAATATGCCTGAGCGCTTAGAGGCTGAGTTTGTCAATGAGAACAATGAGCGTGAAACACCCAT
TATGCTGCATCGTGCGATTCTAGGATCGTTTGAGCGCTTCTTGGGCATGCTAATTGAGCATTATGCCGGCTGGATGCCTG
TATGGCTTGCGCCGCAACAAGTGGTGGTCATGAACATCACTGACAAGCAGGCTGATGCCTGTCAAAATGTGGCCAGCGAG
CTACAAAATGCCGGTCTGCGCGCCATTACTGACTTGCGTAATGAAAAAATTGGATTTAAGATACGAGAAAGAACACTAGA
ACGTATTCCCTATATGCTAGTATTAGGGGATAAGGAAGTTGAGTCAGGACAGGTTAACGTACGTACTCGTGAAGGCGAAA
ACCTTGGCGTCATGTCTGTGGCCGACTTTATCGAATTAGTACAGAAAGCTGTCGCCCAAAAGGGTCGACTAACAACAAAA
ACTGATGAGGAGTAA

Upstream 100 bases:

>100_bases
GGTCAGTTTTTCTGTTTTAATGGTTGTGTTTATTATAATCATCACAATTATAGTGATGGTGTCCTTCTTATTTGCGTTAT
AGATTATTGGATTTAATATT

Downstream 100 bases:

>100_bases
TACCTATTAAACAGTCAAACCGTTTGAACATCAACGAAGAGATTCAGCAAAAAGAAGTTCGCTTAGTGAAAGAAGATGGC
GAACAGATGGGCGTTGTCGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MVAITLPDGNVKEFDGATTVMEVAQSIGPGLAKATIAGRVDGKLVDASDPITQDASVEIVTAKDKDGVDIIRHSTAHLLG
HAVKQLYPNVKMVIGPVIEDGFYYDIFSEKPFTPEDMAAIEKRMAELIKQNYDVIKKMTPREEAIKIFEERGEDYKLKLI
ADMPEEKELGLYHHQEYVDMCRGPHVPNTRFLKVFKLMKMSGAYWRGDAKNEQLQRIYGTAWADKKDLQAYIQRIEEAEK
RDHRKIGKALNLFHMQEQSPGMVFWHPNGWTIYQVLEQYMRKVQKDNGYQEIKTPQIVDRSLWEKSGHWGNYATNMFTTS
SESRDYAVKPMNCPCHVQVFNQGLKSYRELPIRLAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTQAQIQEEVANFI
KLTLDVYKDFGFDQIEMKLSTRPEKRVGTDESWDIAEKALADALDSSGLEWEYLPGEGAFYGPKIEFSLKDSLGRVWQCG
TIQVDPNMPERLEAEFVNENNERETPIMLHRAILGSFERFLGMLIEHYAGWMPVWLAPQQVVVMNITDKQADACQNVASE
LQNAGLRAITDLRNEKIGFKIRERTLERIPYMLVLGDKEVESGQVNVRTREGENLGVMSVADFIELVQKAVAQKGRLTTK
TDEE

Sequences:

>Translated_644_residues
MVAITLPDGNVKEFDGATTVMEVAQSIGPGLAKATIAGRVDGKLVDASDPITQDASVEIVTAKDKDGVDIIRHSTAHLLG
HAVKQLYPNVKMVIGPVIEDGFYYDIFSEKPFTPEDMAAIEKRMAELIKQNYDVIKKMTPREEAIKIFEERGEDYKLKLI
ADMPEEKELGLYHHQEYVDMCRGPHVPNTRFLKVFKLMKMSGAYWRGDAKNEQLQRIYGTAWADKKDLQAYIQRIEEAEK
RDHRKIGKALNLFHMQEQSPGMVFWHPNGWTIYQVLEQYMRKVQKDNGYQEIKTPQIVDRSLWEKSGHWGNYATNMFTTS
SESRDYAVKPMNCPCHVQVFNQGLKSYRELPIRLAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTQAQIQEEVANFI
KLTLDVYKDFGFDQIEMKLSTRPEKRVGTDESWDIAEKALADALDSSGLEWEYLPGEGAFYGPKIEFSLKDSLGRVWQCG
TIQVDPNMPERLEAEFVNENNERETPIMLHRAILGSFERFLGMLIEHYAGWMPVWLAPQQVVVMNITDKQADACQNVASE
LQNAGLRAITDLRNEKIGFKIRERTLERIPYMLVLGDKEVESGQVNVRTREGENLGVMSVADFIELVQKAVAQKGRLTTK
TDEE
>Mature_644_residues
MVAITLPDGNVKEFDGATTVMEVAQSIGPGLAKATIAGRVDGKLVDASDPITQDASVEIVTAKDKDGVDIIRHSTAHLLG
HAVKQLYPNVKMVIGPVIEDGFYYDIFSEKPFTPEDMAAIEKRMAELIKQNYDVIKKMTPREEAIKIFEERGEDYKLKLI
ADMPEEKELGLYHHQEYVDMCRGPHVPNTRFLKVFKLMKMSGAYWRGDAKNEQLQRIYGTAWADKKDLQAYIQRIEEAEK
RDHRKIGKALNLFHMQEQSPGMVFWHPNGWTIYQVLEQYMRKVQKDNGYQEIKTPQIVDRSLWEKSGHWGNYATNMFTTS
SESRDYAVKPMNCPCHVQVFNQGLKSYRELPIRLAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTQAQIQEEVANFI
KLTLDVYKDFGFDQIEMKLSTRPEKRVGTDESWDIAEKALADALDSSGLEWEYLPGEGAFYGPKIEFSLKDSLGRVWQCG
TIQVDPNMPERLEAEFVNENNERETPIMLHRAILGSFERFLGMLIEHYAGWMPVWLAPQQVVVMNITDKQADACQNVASE
LQNAGLRAITDLRNEKIGFKIRERTLERIPYMLVLGDKEVESGQVNVRTREGENLGVMSVADFIELVQKAVAQKGRLTTK
TDEE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=634, Percent_Identity=38.9589905362776, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI38570111, Length=629, Percent_Identity=38.4737678855326, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI20070344, Length=653, Percent_Identity=36.2940275650842, Blast_Score=396, Evalue=1e-110,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=62.992125984252, Blast_Score=865, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=646, Percent_Identity=37.6160990712074, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=646, Percent_Identity=37.6160990712074, Blast_Score=475, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322112, Length=630, Percent_Identity=40, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322654, Length=416, Percent_Identity=38.9423076923077, Blast_Score=306, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24583842, Length=633, Percent_Identity=39.0205371248025, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI28574141, Length=633, Percent_Identity=39.0205371248025, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24583839, Length=633, Percent_Identity=39.0205371248025, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PSYWF (A5WHD5)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001281026.1
- ProteinModelPortal:   A5WHD5
- SMR:   A5WHD5
- STRING:   A5WHD5
- GeneID:   5205054
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_2136
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK00413
- BioCyc:   PSP56811:PSYCPRWF_2136-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73461; Mature: 73461

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAITLPDGNVKEFDGATTVMEVAQSIGPGLAKATIAGRVDGKLVDASDPITQDASVEIV
CEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCCCCEEEE
TAKDKDGVDIIRHSTAHLLGHAVKQLYPNVKMVIGPVIEDGFYYDIFSEKPFTPEDMAAI
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCEEEEECCCCCCCHHHHHHH
EKRMAELIKQNYDVIKKMTPREEAIKIFEERGEDYKLKLIADMPEEKELGLYHHQEYVDM
HHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
CRGPHVPNTRFLKVFKLMKMSGAYWRGDAKNEQLQRIYGTAWADKKDLQAYIQRIEEAEK
HCCCCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RDHRKIGKALNLFHMQEQSPGMVFWHPNGWTIYQVLEQYMRKVQKDNGYQEIKTPQIVDR
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHH
SLWEKSGHWGNYATNMFTTSSESRDYAVKPMNCPCHVQVFNQGLKSYRELPIRLAEFGSC
HHHHCCCCCCCCCCCEEECCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCC
HRNEPSGSLHGLMRVRGFTQDDAHIFCTQAQIQEEVANFIKLTLDVYKDFGFDQIEMKLS
CCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
TRPEKRVGTDESWDIAEKALADALDSSGLEWEYLPGEGAFYGPKIEFSLKDSLGRVWQCG
CCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEEEEEHHCCCCEEECC
TIQVDPNMPERLEAEFVNENNERETPIMLHRAILGSFERFLGMLIEHYAGWMPVWLAPQQ
EEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCE
VVVMNITDKQADACQNVASELQNAGLRAITDLRNEKIGFKIRERTLERIPYMLVLGDKEV
EEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCC
ESGQVNVRTREGENLGVMSVADFIELVQKAVAQKGRLTTKTDEE
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVAITLPDGNVKEFDGATTVMEVAQSIGPGLAKATIAGRVDGKLVDASDPITQDASVEIV
CEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCCCCEEEE
TAKDKDGVDIIRHSTAHLLGHAVKQLYPNVKMVIGPVIEDGFYYDIFSEKPFTPEDMAAI
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCEEEEECCCCCCCHHHHHHH
EKRMAELIKQNYDVIKKMTPREEAIKIFEERGEDYKLKLIADMPEEKELGLYHHQEYVDM
HHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
CRGPHVPNTRFLKVFKLMKMSGAYWRGDAKNEQLQRIYGTAWADKKDLQAYIQRIEEAEK
HCCCCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RDHRKIGKALNLFHMQEQSPGMVFWHPNGWTIYQVLEQYMRKVQKDNGYQEIKTPQIVDR
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHH
SLWEKSGHWGNYATNMFTTSSESRDYAVKPMNCPCHVQVFNQGLKSYRELPIRLAEFGSC
HHHHCCCCCCCCCCCEEECCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCC
HRNEPSGSLHGLMRVRGFTQDDAHIFCTQAQIQEEVANFIKLTLDVYKDFGFDQIEMKLS
CCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
TRPEKRVGTDESWDIAEKALADALDSSGLEWEYLPGEGAFYGPKIEFSLKDSLGRVWQCG
CCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEEEEEHHCCCCEEECC
TIQVDPNMPERLEAEFVNENNERETPIMLHRAILGSFERFLGMLIEHYAGWMPVWLAPQQ
EEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCE
VVVMNITDKQADACQNVASELQNAGLRAITDLRNEKIGFKIRERTLERIPYMLVLGDKEV
EEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCC
ESGQVNVRTREGENLGVMSVADFIELVQKAVAQKGRLTTKTDEE
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA