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The map label for this gene is ispA [H]

Identifier: 148653898

GI number: 148653898

Start: 2621901

End: 2622836

Strand: Direct

Name: ispA [H]

Synonym: PsycPRwf_2101

Alternate gene names: 148653898

Gene position: 2621901-2622836 (Clockwise)

Preceding gene: 148653892

Following gene: 148653899

Centisome position: 88.01

GC content: 49.47

Gene sequence:

>936_bases
ATGACTAATCAGCACCTCAACTTTGACACTCTCAGCCAACAGGTCATCTCTACCTTACAAGCGGATATCGAGACCCTGCT
TAATCATGCCAATCTGCCTAGCCCCTTACATGAGGCCTGCCACTATGCCATGACTGGGCAAGGCAAAAAAGTGCGTCCAT
TGCTAGTGGCCAGCAGCTATCTTACCGTGCTTGCCAGTAGTCAGGCGGCCACAATCGACACCTTACCCCTCTTTGATGAC
AACTGTCGCCGTGCCATGTTAGCGGTTGAATTCTTGCACACCTACTCACTAATTCATGATGATCTGCCTTGTATGGATGA
CGATGACTTGCGCCGTGGCCGTCCCACTTGCCATATTAAGTTTGGTGAGGCGACAGCCCTGCTGGCCGGCGATGTGTTGC
AGACCTTGGCTTTTGAAGCTTTAAGCGCTGACTTGCCTGGTTTTGCGCCCATATCCAATGACAAAGCGGCCAGCTTACTT
ACCCTTTTTGCACCCCGTGCCCGCCGTATGGTGTCAGGTCAGATGCTGGACTTAAATGCTGAGAACAAACAAGTGAGTCA
GCCTCAGCTTGAGGCCATTCACCGCGATAAAACTGGGGCGTTAATTGAGGCTGCGGTGTTAATGGGCGCCGCCTGCGCTG
ATGCCAATGACACTCAATACCAAGCCATTACTTCATTTGCCAGTAATGTGGGCTTAGCATTTCAGGTCCAAGACGATATC
TTGGATGTCACCTCAAGTACCGATACTTTAGGCAAGCCTACTGGCAGTGATGAGGGACTTAACAAATCGACTTATGTCAA
ATTGATGGGCGTAGAGGCTGCCACCGACTATGCCAAGTCATTATTTTTGGCGGCAACTCAAGCCATCGATGATAATTTTG
ATAAAAATAGCAGCTTAATCGACTTAGCACAGTGGTTGTGGCAGCGTCAAAAATAA

Upstream 100 bases:

>100_bases
GGTAAAGGCCAGCGGCTACGCTAAATTTCTCCCTCTCATGGTAAACTACGCCTCCTAATCTTCTCTTATCGTCCTAATTT
TGTTTATCGGGTCCGCTTTT

Downstream 100 bases:

>100_bases
CAAGCTTGATACGCTATCGATACTATTAGCCCCTATCATATTTGATTATAATAGATAACTTATACTGTCAGCTGTTGGGC
AGGCTTAGCTTAATCAATAA

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTNQHLNFDTLSQQVISTLQADIETLLNHANLPSPLHEACHYAMTGQGKKVRPLLVASSYLTVLASSQAATIDTLPLFDD
NCRRAMLAVEFLHTYSLIHDDLPCMDDDDLRRGRPTCHIKFGEATALLAGDVLQTLAFEALSADLPGFAPISNDKAASLL
TLFAPRARRMVSGQMLDLNAENKQVSQPQLEAIHRDKTGALIEAAVLMGAACADANDTQYQAITSFASNVGLAFQVQDDI
LDVTSSTDTLGKPTGSDEGLNKSTYVKLMGVEAATDYAKSLFLAATQAIDDNFDKNSSLIDLAQWLWQRQK

Sequences:

>Translated_311_residues
MTNQHLNFDTLSQQVISTLQADIETLLNHANLPSPLHEACHYAMTGQGKKVRPLLVASSYLTVLASSQAATIDTLPLFDD
NCRRAMLAVEFLHTYSLIHDDLPCMDDDDLRRGRPTCHIKFGEATALLAGDVLQTLAFEALSADLPGFAPISNDKAASLL
TLFAPRARRMVSGQMLDLNAENKQVSQPQLEAIHRDKTGALIEAAVLMGAACADANDTQYQAITSFASNVGLAFQVQDDI
LDVTSSTDTLGKPTGSDEGLNKSTYVKLMGVEAATDYAKSLFLAATQAIDDNFDKNSSLIDLAQWLWQRQK
>Mature_310_residues
TNQHLNFDTLSQQVISTLQADIETLLNHANLPSPLHEACHYAMTGQGKKVRPLLVASSYLTVLASSQAATIDTLPLFDDN
CRRAMLAVEFLHTYSLIHDDLPCMDDDDLRRGRPTCHIKFGEATALLAGDVLQTLAFEALSADLPGFAPISNDKAASLLT
LFAPRARRMVSGQMLDLNAENKQVSQPQLEAIHRDKTGALIEAAVLMGAACADANDTQYQAITSFASNVGLAFQVQDDIL
DVTSSTDTLGKPTGSDEGLNKSTYVKLMGVEAATDYAKSLFLAATQAIDDNFDKNSSLIDLAQWLWQRQK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=238, Percent_Identity=33.6134453781513, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786623, Length=293, Percent_Identity=45.7337883959044, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1789578, Length=231, Percent_Identity=26.4069264069264, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17505681, Length=264, Percent_Identity=25.3787878787879, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651612, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33788; Mature: 33657

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQHLNFDTLSQQVISTLQADIETLLNHANLPSPLHEACHYAMTGQGKKVRPLLVASSY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
LTVLASSQAATIDTLPLFDDNCRRAMLAVEFLHTYSLIHDDLPCMDDDDLRRGRPTCHIK
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEE
FGEATALLAGDVLQTLAFEALSADLPGFAPISNDKAASLLTLFAPRARRMVSGQMLDLNA
ECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCC
ENKQVSQPQLEAIHRDKTGALIEAAVLMGAACADANDTQYQAITSFASNVGLAFQVQDDI
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHH
LDVTSSTDTLGKPTGSDEGLNKSTYVKLMGVEAATDYAKSLFLAATQAIDDNFDKNSSLI
HHHCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
DLAQWLWQRQK
HHHHHHHHCCC
>Mature Secondary Structure 
TNQHLNFDTLSQQVISTLQADIETLLNHANLPSPLHEACHYAMTGQGKKVRPLLVASSY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
LTVLASSQAATIDTLPLFDDNCRRAMLAVEFLHTYSLIHDDLPCMDDDDLRRGRPTCHIK
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEE
FGEATALLAGDVLQTLAFEALSADLPGFAPISNDKAASLLTLFAPRARRMVSGQMLDLNA
ECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCC
ENKQVSQPQLEAIHRDKTGALIEAAVLMGAACADANDTQYQAITSFASNVGLAFQVQDDI
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHH
LDVTSSTDTLGKPTGSDEGLNKSTYVKLMGVEAATDYAKSLFLAATQAIDDNFDKNSSLI
HHHCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
DLAQWLWQRQK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]