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The map label for this gene is betT [H]

Identifier: 148653716

GI number: 148653716

Start: 2383299

End: 2385551

Strand: Direct

Name: betT [H]

Synonym: PsycPRwf_1919

Alternate gene names: 148653716

Gene position: 2383299-2385551 (Clockwise)

Preceding gene: 148653714

Following gene: 148653719

Centisome position: 80.0

GC content: 50.16

Gene sequence:

>2253_bases
GTGGCCAAAGATCCAAATGAGCCTCAACAAACAAAAGAGCCATTGGCAACCGACTCATCCAATCATCAGCACTCTGAATC
GAGCGCTCAGTCTGAACCCAAAACGCCTACCAAAGCCTCACGCACCCCCTTTGAGCGCAGCCAATTTGGTGGCACTCAGC
GCACAGCCAAACCCAGTGACGATGATCGCCCCCTCTCCCGTAGCGACCTAAAAAAAGGCGCACAAGAGATGTCCACGCAC
AGCGTTGCACACGTGAATTGGAGTGTGCTCATCATCTCCTCACTGATTATTACTATGTTTTCATTATGGGCTATCTTTTT
ACCCAAAATAGCTAGCACCACAATGAAAATGGTTGTGGGCTGGATTGCCACCAATTTAGGCTGGTATTACGTCATCACCA
TGGTGCTGGTGATTGGCTTTGTGATTTGGGTGGCTTTGTCAAAAAATGGCAGTGTACGCCTTGGCCCAGATGACTCTCGT
CCGCAATATAAGCTAGGCACTTGGGCGGCCATGCTATTTGCTGCTGGCGTCGGCATCGATATGCTCTTCTTCTCCGTGAC
CGGTCCAGTGGTTCAATATCTCACACCACCAACCGGCGAGGGCGCAAGCGCAGAGGCGATGCAAAACGCTGTCGTCTGGA
CCATGTTCCATTACGGTATTGCTGGGTGGTCAGTGTATGCGCTGCTTGGTATGGCCATGGGCTACTTTGCTTATCGCTGG
AACATGCCTTTGTCACTGAGAGCTGCGTTATACCCGCTGCTGGGCAAACGGGTGAATGGTCCGATTGGGCATGCAATTAG
TACCATCTCATTAGTAGGTACCGTATTTGGGGTGGCCACCACCATGGGCATCGGTGTGGTGCTATTAAATGTTGGCTTCT
CTAAACTATTTGGGCTACCAGAGGGACTGGCTTTACAAATATCGTTAGTCATTGGCGCGGTGATATTGACGATTCTGTCG
ACCACTTCTGGCGTTGATCGCGGCGTACGCTGGATATCTGAGCTCAATTTGTGGAGCGCGGTAGCAATGATGGTGTTTAT
CCTATTTGCCGGTCAGACCGCCTTCTTGCTAAATGGCCTGGTCGAAAACTTGGGCCAATTCTTTGTCACCTTGCCAGCAC
GCATGTTCCAAACCTTTGTCTATGAGCCTGGCAGCAGCGATTGGATGGGCAGCTGGACCTTATTCTTTTGGGCGTTTTGG
TTGGCTTGGGGGCCGTTTGTTGGCGTGTTCTTAGCCCGTATCTCACGCGGCCGAACTTTACGTGAGTTTGTGATAGCTGC
CATTACCATTCCTGTGTTATGCGACTTTATTATTGTCTCATTCTTCGGCAACTCAGCCCTTTATGAGGTGGTGTTCAATG
GCAATACCGAGTTTGCCGCACTGGCTGTCGCAAATCCAGAACAGGGCTGGTATGCCCTACTCGAGCTGTTTCCCGGCGCG
CCTTTTTTGGTTGCCTTAGCCACCTTATCAGGCCTACTGTTTTATATCACCAGCGCCAACTCAGGTGCGATGGTGATGTC
AAACTTCTCGACCTCTATTCCCGACCCTGCCGAAGATGGGCCAAAATGGCTGCGTATATTCTGGGCGGTGTTGACCGCGG
TATCAACCATCTCAATGCTAATTGCTGGCGGTGTCATCACGATGGAATACGCCACCTTAATATTCGCCTTACCGGTGACC
ATTATTGCTTATTTGGTCATGTTCTCGTTTTATAAAGCACTCAAAATTGAGCGTGCTGAAAACGAAGGTAAAGTATTAAG
ACGCCCAACTGTCGCACCCAGTGGCAGCACCATTCCTGAGCGCTCTTGGAAACAACGCTTGGGACAGATGCTCACCTATC
CCTCTAAGCGTGAGGCTATGCAGTTTTTGGATCGTGTGGTTCGTCCTGCGCTGTCTGATGTGGCCAATGAGTTTGAGCGT
CAAGGCTATCAGGTTGACCGTCATAGCATCCCAAATGTGGGTAACAGCGATGACTCTGAGCTTGCCGGCCCTATTCTTAG
TGTCTTCACTGACGCACAAGACAAGTTCTTCTATCAAGTCACCGCGGTGAAGATACCGGCACCAACATTTAGTGGTAAAG
TTGCGCCCAATACGGATACCTATTATCGCTTGGAGGTGACTACTCAAACGGGATCTGGTGGTTACGATCTGATGGGACTG
ACCAAACAGCAGGTGATTGATGATGTGCTTGAACAATATGAGGCGTATTTGACGTTCTTGAGTACGCCAGCTTCTGATAG
CCATCATTTATAG

Upstream 100 bases:

>100_bases
ATGATTCAATTACTACGGCATTTTAGCCCCCAAAGCCGCTTAGATAATTAGTCTAAGCAGGGTCACCCGCTGCAATGCCG
TCACTCTAAGGAGAGATACC

Downstream 100 bases:

>100_bases
CGCTTCATTGAATGACAGATTATGGCTTAACTAAAATAAGCCCCTTTGATAGGGGCTTGTTTGTTATCTGACTAAATAAA
GGGTTTATTCCTGAATGAGA

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MAKDPNEPQQTKEPLATDSSNHQHSESSAQSEPKTPTKASRTPFERSQFGGTQRTAKPSDDDRPLSRSDLKKGAQEMSTH
SVAHVNWSVLIISSLIITMFSLWAIFLPKIASTTMKMVVGWIATNLGWYYVITMVLVIGFVIWVALSKNGSVRLGPDDSR
PQYKLGTWAAMLFAAGVGIDMLFFSVTGPVVQYLTPPTGEGASAEAMQNAVVWTMFHYGIAGWSVYALLGMAMGYFAYRW
NMPLSLRAALYPLLGKRVNGPIGHAISTISLVGTVFGVATTMGIGVVLLNVGFSKLFGLPEGLALQISLVIGAVILTILS
TTSGVDRGVRWISELNLWSAVAMMVFILFAGQTAFLLNGLVENLGQFFVTLPARMFQTFVYEPGSSDWMGSWTLFFWAFW
LAWGPFVGVFLARISRGRTLREFVIAAITIPVLCDFIIVSFFGNSALYEVVFNGNTEFAALAVANPEQGWYALLELFPGA
PFLVALATLSGLLFYITSANSGAMVMSNFSTSIPDPAEDGPKWLRIFWAVLTAVSTISMLIAGGVITMEYATLIFALPVT
IIAYLVMFSFYKALKIERAENEGKVLRRPTVAPSGSTIPERSWKQRLGQMLTYPSKREAMQFLDRVVRPALSDVANEFER
QGYQVDRHSIPNVGNSDDSELAGPILSVFTDAQDKFFYQVTAVKIPAPTFSGKVAPNTDTYYRLEVTTQTGSGGYDLMGL
TKQQVIDDVLEQYEAYLTFLSTPASDSHHL

Sequences:

>Translated_750_residues
MAKDPNEPQQTKEPLATDSSNHQHSESSAQSEPKTPTKASRTPFERSQFGGTQRTAKPSDDDRPLSRSDLKKGAQEMSTH
SVAHVNWSVLIISSLIITMFSLWAIFLPKIASTTMKMVVGWIATNLGWYYVITMVLVIGFVIWVALSKNGSVRLGPDDSR
PQYKLGTWAAMLFAAGVGIDMLFFSVTGPVVQYLTPPTGEGASAEAMQNAVVWTMFHYGIAGWSVYALLGMAMGYFAYRW
NMPLSLRAALYPLLGKRVNGPIGHAISTISLVGTVFGVATTMGIGVVLLNVGFSKLFGLPEGLALQISLVIGAVILTILS
TTSGVDRGVRWISELNLWSAVAMMVFILFAGQTAFLLNGLVENLGQFFVTLPARMFQTFVYEPGSSDWMGSWTLFFWAFW
LAWGPFVGVFLARISRGRTLREFVIAAITIPVLCDFIIVSFFGNSALYEVVFNGNTEFAALAVANPEQGWYALLELFPGA
PFLVALATLSGLLFYITSANSGAMVMSNFSTSIPDPAEDGPKWLRIFWAVLTAVSTISMLIAGGVITMEYATLIFALPVT
IIAYLVMFSFYKALKIERAENEGKVLRRPTVAPSGSTIPERSWKQRLGQMLTYPSKREAMQFLDRVVRPALSDVANEFER
QGYQVDRHSIPNVGNSDDSELAGPILSVFTDAQDKFFYQVTAVKIPAPTFSGKVAPNTDTYYRLEVTTQTGSGGYDLMGL
TKQQVIDDVLEQYEAYLTFLSTPASDSHHL
>Mature_749_residues
AKDPNEPQQTKEPLATDSSNHQHSESSAQSEPKTPTKASRTPFERSQFGGTQRTAKPSDDDRPLSRSDLKKGAQEMSTHS
VAHVNWSVLIISSLIITMFSLWAIFLPKIASTTMKMVVGWIATNLGWYYVITMVLVIGFVIWVALSKNGSVRLGPDDSRP
QYKLGTWAAMLFAAGVGIDMLFFSVTGPVVQYLTPPTGEGASAEAMQNAVVWTMFHYGIAGWSVYALLGMAMGYFAYRWN
MPLSLRAALYPLLGKRVNGPIGHAISTISLVGTVFGVATTMGIGVVLLNVGFSKLFGLPEGLALQISLVIGAVILTILST
TSGVDRGVRWISELNLWSAVAMMVFILFAGQTAFLLNGLVENLGQFFVTLPARMFQTFVYEPGSSDWMGSWTLFFWAFWL
AWGPFVGVFLARISRGRTLREFVIAAITIPVLCDFIIVSFFGNSALYEVVFNGNTEFAALAVANPEQGWYALLELFPGAP
FLVALATLSGLLFYITSANSGAMVMSNFSTSIPDPAEDGPKWLRIFWAVLTAVSTISMLIAGGVITMEYATLIFALPVTI
IAYLVMFSFYKALKIERAENEGKVLRRPTVAPSGSTIPERSWKQRLGQMLTYPSKREAMQFLDRVVRPALSDVANEFERQ
GYQVDRHSIPNVGNSDDSELAGPILSVFTDAQDKFFYQVTAVKIPAPTFSGKVAPNTDTYYRLEVTTQTGSGGYDLMGLT
KQQVIDDVLEQYEAYLTFLSTPASDSHHL

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=666, Percent_Identity=43.8438438438438, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1788102, Length=454, Percent_Identity=27.5330396475771, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI1786224, Length=476, Percent_Identity=24.7899159663866, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 82273; Mature: 82142

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AKDPNEPQQTKEPLATDSSNHQHSESSAQSEPKTPTKASRTPFERSQFGGTQRTAKPSD
CCCCCCCHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC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CHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]