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The map label for this gene is gcvT [H]

Identifier: 148653519

GI number: 148653519

Start: 2129772

End: 2130917

Strand: Direct

Name: gcvT [H]

Synonym: PsycPRwf_1722

Alternate gene names: 148653519

Gene position: 2129772-2130917 (Clockwise)

Preceding gene: 148653511

Following gene: 148653520

Centisome position: 71.49

GC content: 46.6

Gene sequence:

>1146_bases
ATGACCACCTTACAACGTACCCCTTTTTATCAGTCGCATTTAGACAATAACGGTAAGATTGTTGATTTTTCTGGCTGGGA
GCTGCCCATCCATTACGGATCTCAAATTGATGAGCATGAAGCAGTCCGTACCGATGCCGGTATGTTTGATGTGTCACATA
TGGTGATTACTGATGTTGAAGGCGCTCAGGCAAAAGCTTGGCTACAAAAGCTGTTGGCAAATGACGTGGCCAAACTAAAG
ACTGTCGGCAAAGCGCTGTACTCTGGCATGCTAAACGCAGACGGCGGTGTTATTGACGATTTGATTGTCTATTTGATCAA
CGAAGATGAGACCCAATACCGTATTATCTCAAACGCCGCTACCCGTGATAAAGACTTGGCTCAGTTTAATAAAGTGGCCG
AAGATTTCGATGTGCGTCTAACAGAACGTCCTGAATTGGCAATCTTAGCTGTTCAAGGTCCAAAAGCTGTGGCCAAATTA
AAACGAGCCAAACCTGCTTGGGCGGATACTTTAGATGCTCTTAAACCTTTTGTTGGTGCAGATTTAACCGATATCGAAGG
CAATGACTGGTTTGTGGCGCGTACCGGCTATACTGGTGAAGATGGTGTTGAGGTTATTTTGCATGGTGATCACGCCTCTG
ACTTTTACAAGTTATTATTAGAGCATGAAATCAAGCCAGCTGGTCTGGGCGCACGAGATACCTTGCGTATGGAAGCTGGC
ATGAACTTATACGGCCATGACATGGACGATACAGTGAGCCCTTATGAGTGCAACATGGGCTGGACCTTGGCATTAAAAGA
TGACCGTGATTTTGTGGGCCGTGAAGCTTTAGTTGCCAAGCGCAAGCAGTCACAAGAAGAAGGTAGCGCCATGAAGCAGG
TGGGCTTATTGCTTGAGACCCGCGGCGTACTGCGTGAAGGCATGAGCGTTACCATCAATCAAGGCACAGATAAAGAAAGT
AGCGGTATTATCACCAGCGGTACTTTCTCGCCTACCCTAAAACAATCTATCGCCATCGCACGTGTTCCAGAGTCAGTCAC
CGATGAAGACACGGTACAAGTCGATTTACGCGGCAAGGGTAAATTTGTCGATGTCCGTGTGTTAAAGCTGCCTTTTGTGC
GTAATGGCGCTAAGCAATTTGACTAA

Upstream 100 bases:

>100_bases
ATGATTTTTTTGATGATTTGCTATCCGCATCATTTACGATACAGTAGGTATTCACTTAAGTTTTATTAACTGCTTTTATT
ACTAACCATAAGGATTTGTC

Downstream 100 bases:

>100_bases
TAGCCATTTATTGCTCTGCTAGCCAAGCTGTGCCCTGATTTAAGGCCTATTTTCGACCAAATTTCTATCGCATTTTTATT
TTTTTGGTAATCGAAAATAG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTTLQRTPFYQSHLDNNGKIVDFSGWELPIHYGSQIDEHEAVRTDAGMFDVSHMVITDVEGAQAKAWLQKLLANDVAKLK
TVGKALYSGMLNADGGVIDDLIVYLINEDETQYRIISNAATRDKDLAQFNKVAEDFDVRLTERPELAILAVQGPKAVAKL
KRAKPAWADTLDALKPFVGADLTDIEGNDWFVARTGYTGEDGVEVILHGDHASDFYKLLLEHEIKPAGLGARDTLRMEAG
MNLYGHDMDDTVSPYECNMGWTLALKDDRDFVGREALVAKRKQSQEEGSAMKQVGLLLETRGVLREGMSVTINQGTDKES
SGIITSGTFSPTLKQSIAIARVPESVTDEDTVQVDLRGKGKFVDVRVLKLPFVRNGAKQFD

Sequences:

>Translated_381_residues
MTTLQRTPFYQSHLDNNGKIVDFSGWELPIHYGSQIDEHEAVRTDAGMFDVSHMVITDVEGAQAKAWLQKLLANDVAKLK
TVGKALYSGMLNADGGVIDDLIVYLINEDETQYRIISNAATRDKDLAQFNKVAEDFDVRLTERPELAILAVQGPKAVAKL
KRAKPAWADTLDALKPFVGADLTDIEGNDWFVARTGYTGEDGVEVILHGDHASDFYKLLLEHEIKPAGLGARDTLRMEAG
MNLYGHDMDDTVSPYECNMGWTLALKDDRDFVGREALVAKRKQSQEEGSAMKQVGLLLETRGVLREGMSVTINQGTDKES
SGIITSGTFSPTLKQSIAIARVPESVTDEDTVQVDLRGKGKFVDVRVLKLPFVRNGAKQFD
>Mature_380_residues
TTLQRTPFYQSHLDNNGKIVDFSGWELPIHYGSQIDEHEAVRTDAGMFDVSHMVITDVEGAQAKAWLQKLLANDVAKLKT
VGKALYSGMLNADGGVIDDLIVYLINEDETQYRIISNAATRDKDLAQFNKVAEDFDVRLTERPELAILAVQGPKAVAKLK
RAKPAWADTLDALKPFVGADLTDIEGNDWFVARTGYTGEDGVEVILHGDHASDFYKLLLEHEIKPAGLGARDTLRMEAGM
NLYGHDMDDTVSPYECNMGWTLALKDDRDFVGREALVAKRKQSQEEGSAMKQVGLLLETRGVLREGMSVTINQGTDKESS
GIITSGTFSPTLKQSIAIARVPESVTDEDTVQVDLRGKGKFVDVRVLKLPFVRNGAKQFD

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=381, Percent_Identity=37.007874015748, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=37.0473537604457, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI257796254, Length=377, Percent_Identity=32.6259946949602, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI257796256, Length=327, Percent_Identity=35.1681957186544, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24797151, Length=331, Percent_Identity=26.2839879154079, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=51.8716577540107, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=33.8582677165354, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71994052, Length=373, Percent_Identity=23.8605898123324, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994045, Length=373, Percent_Identity=23.8605898123324, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=387, Percent_Identity=31.7829457364341, Blast_Score=176, Evalue=7e-45,
Organism=Drosophila melanogaster, GI20129441, Length=389, Percent_Identity=34.1902313624679, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28571104, Length=272, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42063; Mature: 41932

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLQRTPFYQSHLDNNGKIVDFSGWELPIHYGSQIDEHEAVRTDAGMFDVSHMVITDVE
CCCCCCCCCHHHHCCCCCCEEEECCCEEEEECCCCCCHHHHHHCCCCCEEECEEEEECCC
GAQAKAWLQKLLANDVAKLKTVGKALYSGMLNADGGVIDDLIVYLINEDETQYRIISNAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCEEEEEECCC
TRDKDLAQFNKVAEDFDVRLTERPELAILAVQGPKAVAKLKRAKPAWADTLDALKPFVGA
CCCHHHHHHHHHHHHHCEEEECCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCC
DLTDIEGNDWFVARTGYTGEDGVEVILHGDHASDFYKLLLEHEIKPAGLGARDTLRMEAG
CCEECCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEHHCC
MNLYGHDMDDTVSPYECNMGWTLALKDDRDFVGREALVAKRKQSQEEGSAMKQVGLLLET
CCEECCCCCCCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVLREGMSVTINQGTDKESSGIITSGTFSPTLKQSIAIARVPESVTDEDTVQVDLRGKG
HHHHHCCCEEEEECCCCCCCCCEEECCCCCHHHHHHEEEEECCCCCCCCCEEEEEECCCC
KFVDVRVLKLPFVRNGAKQFD
CEEEEEEEEECHHCCCCCCCC
>Mature Secondary Structure 
TTLQRTPFYQSHLDNNGKIVDFSGWELPIHYGSQIDEHEAVRTDAGMFDVSHMVITDVE
CCCCCCCCHHHHCCCCCCEEEECCCEEEEECCCCCCHHHHHHCCCCCEEECEEEEECCC
GAQAKAWLQKLLANDVAKLKTVGKALYSGMLNADGGVIDDLIVYLINEDETQYRIISNAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCEEEEEECCC
TRDKDLAQFNKVAEDFDVRLTERPELAILAVQGPKAVAKLKRAKPAWADTLDALKPFVGA
CCCHHHHHHHHHHHHHCEEEECCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCC
DLTDIEGNDWFVARTGYTGEDGVEVILHGDHASDFYKLLLEHEIKPAGLGARDTLRMEAG
CCEECCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEHHCC
MNLYGHDMDDTVSPYECNMGWTLALKDDRDFVGREALVAKRKQSQEEGSAMKQVGLLLET
CCEECCCCCCCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVLREGMSVTINQGTDKESSGIITSGTFSPTLKQSIAIARVPESVTDEDTVQVDLRGKG
HHHHHCCCEEEEECCCCCCCCCEEECCCCCHHHHHHEEEEECCCCCCCCCEEEEEECCCC
KFVDVRVLKLPFVRNGAKQFD
CEEEEEEEEECHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]