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The map label for this gene is glcA [C]

Identifier: 148653478

GI number: 148653478

Start: 2078685

End: 2080442

Strand: Direct

Name: glcA [C]

Synonym: PsycPRwf_1681

Alternate gene names: 148653478

Gene position: 2078685-2080442 (Clockwise)

Preceding gene: 148653477

Following gene: 148653479

Centisome position: 69.78

GC content: 45.34

Gene sequence:

>1758_bases
ATGTATACTTTTTTGGCTTTAACTCCCATCTTGGCGGTTTTCTTACTGTTGGTGGTGCTACGGCTTCCAGCTAAAATTGC
CATGAGTCTCACTTTTGTGATAACTGCACTACTGTCCTTACTGGTTTGGCATACTTCAAGTGCCCAAGTCGCAGCTGCCT
CTTTAAATGGCGTGATTGTGGCACTGACTATTTTATTTATTGTTTTTGCCGCAATTTTGCTGCTAAATACCTTAACAGAG
AGTGGCGCTATTATTGCCATTCGTAGAGGTTTCATGGATATTTCACCCGACCGCCGTGTGCAAGCCATCATCGTGGGTTG
GTTGTTTTGCTCATTGGTAGAAGGCTCTTCAGGATTTGGCACGCCCTCTGCGGTAGGTGCACCTTTGTTATTGGCACTGG
GCTTCCCTGCTATGGCGTCTGTCATGGTGATGCTTATCATTCAATCCACACCCGTCTCTTTTGGTGCAGTAGGCACGCCT
TTATTAGTAGGTGTGTGGTCAGGTATTGAAGGTAAGCAAGACTTAACTCAGTCTATCGCGCCAATGAGCCCTGAAAACTA
CCTATTACAAATCACCGCTAACGTAGGCTTATTGCATGCACTCATCGGTGTACTCATTCCTCTTATCCTCAGTGCTTTTT
TGACCCGCTTCTTCGGTGAAAAAAGATCATTTATTGAAGGTTTAAAAGTCTGGCCATTTGCTTTATTCGCCGGTATCTGT
TTTACGCTCCCTTATTATTTAGTCGCCAAATACCTAGGTCCCGAATTCCCCTCTTTGGTCGGCGGTTTTATTGGTCTTAT
GATTGTGGTACCTGCAGCCAAACGTGGCTTTTTGATGCCAAAAGAAACCTTTGACTTCGGTCCTAGAGCTGCTTGGGATA
AAGATTGGGTAGGCACATTGGCTGAAGAGAAGTATGATGATACTGTCGCACCTAGATTTTCTATCGGTCGTGCTTTTTCT
CCTTATATTATCGTTATCGCTCTATTAATTTTGACCCGAGTGATTGCCCCATTAAAAGCATTTTTAGTGGGAGACAGTGC
GACTTTAACTATCTCCAACTTATTCGGTACCGAAATATCCAGTAAAATACAGCTACTCTATTCTCCAGGTAGCATATTAA
TCATCACCTCACTACTGTGTGTGTGGCTATATAAAATGGATGGCGCTTCGGTTAAGCGCAGTTGGAGTGGCTCAGCTAAA
ACCATGATGGCAGCAGCACCAGCGCTTTTATTCTCGGTGCCTATGGTGCAAGTATTCATCAACTCAGGCTCCACAGCAGA
CTTGGCCACCAGCTTGCCTGCCATGCCTATTTTATTGGCACAAAGTGCTGCAGATGCGTTCCATGATACTTGGCCACTAA
TCTCACCTTGGATTGGGGCTATGGGCGCTTTTATTGCCGGCTCTAATACCATTAGTAATATGATGTTCTCATACTTTCAG
TGGTCCACAGCAAGTCAAATTGGTCTGGGTCCTGACTTAGCTGCGCAGATCGTCGCATTACAAGCCATTGGGGGCGCAGC
AGGCAACATGGTATCGGTACATAACGTGGTGGCTGCTTGTGCTGTCGTGGGCTTGGTCAATAAAGAGGGCTATGTTATCC
GTAAAACCTTAGTAGCCATGACTTATTATGTGGTTCAAGCTGGCTTCTTAGGGATGGCGTTAATTTTTGGCAACATTATG
TGGTGGATGATGGCAGTGGCTTGGCCGATAGGCTTCTTGGTCATTATGTCGTTAACGACAAAAGGTGCAAAGGCCTAA

Upstream 100 bases:

>100_bases
GCTGCCAACTCCCTTTATTATTAATGGTTTGATTGATTGACTTATTGGTTATGTCTTAAAAATACCCGCTAAATCCATTC
GCACTATACAAGGATGTTTT

Downstream 100 bases:

>100_bases
ATGCCTCATTAATAATAAAAAAGCACTAAAATTTACTGTATTTTAAAACCGTCATTAATAAGAGGGCTGATATGAAAGAC
TTAACCAAAATGACCGAGAT

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MYTFLALTPILAVFLLLVVLRLPAKIAMSLTFVITALLSLLVWHTSSAQVAAASLNGVIVALTILFIVFAAILLLNTLTE
SGAIIAIRRGFMDISPDRRVQAIIVGWLFCSLVEGSSGFGTPSAVGAPLLLALGFPAMASVMVMLIIQSTPVSFGAVGTP
LLVGVWSGIEGKQDLTQSIAPMSPENYLLQITANVGLLHALIGVLIPLILSAFLTRFFGEKRSFIEGLKVWPFALFAGIC
FTLPYYLVAKYLGPEFPSLVGGFIGLMIVVPAAKRGFLMPKETFDFGPRAAWDKDWVGTLAEEKYDDTVAPRFSIGRAFS
PYIIVIALLILTRVIAPLKAFLVGDSATLTISNLFGTEISSKIQLLYSPGSILIITSLLCVWLYKMDGASVKRSWSGSAK
TMMAAAPALLFSVPMVQVFINSGSTADLATSLPAMPILLAQSAADAFHDTWPLISPWIGAMGAFIAGSNTISNMMFSYFQ
WSTASQIGLGPDLAAQIVALQAIGGAAGNMVSVHNVVAACAVVGLVNKEGYVIRKTLVAMTYYVVQAGFLGMALIFGNIM
WWMMAVAWPIGFLVIMSLTTKGAKA

Sequences:

>Translated_585_residues
MYTFLALTPILAVFLLLVVLRLPAKIAMSLTFVITALLSLLVWHTSSAQVAAASLNGVIVALTILFIVFAAILLLNTLTE
SGAIIAIRRGFMDISPDRRVQAIIVGWLFCSLVEGSSGFGTPSAVGAPLLLALGFPAMASVMVMLIIQSTPVSFGAVGTP
LLVGVWSGIEGKQDLTQSIAPMSPENYLLQITANVGLLHALIGVLIPLILSAFLTRFFGEKRSFIEGLKVWPFALFAGIC
FTLPYYLVAKYLGPEFPSLVGGFIGLMIVVPAAKRGFLMPKETFDFGPRAAWDKDWVGTLAEEKYDDTVAPRFSIGRAFS
PYIIVIALLILTRVIAPLKAFLVGDSATLTISNLFGTEISSKIQLLYSPGSILIITSLLCVWLYKMDGASVKRSWSGSAK
TMMAAAPALLFSVPMVQVFINSGSTADLATSLPAMPILLAQSAADAFHDTWPLISPWIGAMGAFIAGSNTISNMMFSYFQ
WSTASQIGLGPDLAAQIVALQAIGGAAGNMVSVHNVVAACAVVGLVNKEGYVIRKTLVAMTYYVVQAGFLGMALIFGNIM
WWMMAVAWPIGFLVIMSLTTKGAKA
>Mature_585_residues
MYTFLALTPILAVFLLLVVLRLPAKIAMSLTFVITALLSLLVWHTSSAQVAAASLNGVIVALTILFIVFAAILLLNTLTE
SGAIIAIRRGFMDISPDRRVQAIIVGWLFCSLVEGSSGFGTPSAVGAPLLLALGFPAMASVMVMLIIQSTPVSFGAVGTP
LLVGVWSGIEGKQDLTQSIAPMSPENYLLQITANVGLLHALIGVLIPLILSAFLTRFFGEKRSFIEGLKVWPFALFAGIC
FTLPYYLVAKYLGPEFPSLVGGFIGLMIVVPAAKRGFLMPKETFDFGPRAAWDKDWVGTLAEEKYDDTVAPRFSIGRAFS
PYIIVIALLILTRVIAPLKAFLVGDSATLTISNLFGTEISSKIQLLYSPGSILIITSLLCVWLYKMDGASVKRSWSGSAK
TMMAAAPALLFSVPMVQVFINSGSTADLATSLPAMPILLAQSAADAFHDTWPLISPWIGAMGAFIAGSNTISNMMFSYFQ
WSTASQIGLGPDLAAQIVALQAIGGAAGNMVSVHNVVAACAVVGLVNKEGYVIRKTLVAMTYYVVQAGFLGMALIFGNIM
WWMMAVAWPIGFLVIMSLTTKGAKA

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=560, Percent_Identity=27.8571428571429, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1790031, Length=557, Percent_Identity=27.8276481149013, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 62378; Mature: 62378

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTFLALTPILAVFLLLVVLRLPAKIAMSLTFVITALLSLLVWHTSSAQVAAASLNGVIV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHH
ALTILFIVFAAILLLNTLTESGAIIAIRRGFMDISPDRRVQAIIVGWLFCSLVEGSSGFG
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
TPSAVGAPLLLALGFPAMASVMVMLIIQSTPVSFGAVGTPLLVGVWSGIEGKQDLTQSIA
CCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHC
PMSPENYLLQITANVGLLHALIGVLIPLILSAFLTRFFGEKRSFIEGLKVWPFALFAGIC
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FTLPYYLVAKYLGPEFPSLVGGFIGLMIVVPAAKRGFLMPKETFDFGPRAAWDKDWVGTL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCCCCCHHCCCCCCCCCCCHHHHHH
AEEKYDDTVAPRFSIGRAFSPYIIVIALLILTRVIAPLKAFLVGDSATLTISNLFGTEIS
HHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCC
SKIQLLYSPGSILIITSLLCVWLYKMDGASVKRSWSGSAKTMMAAAPALLFSVPMVQVFI
CCEEEEECCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
NSGSTADLATSLPAMPILLAQSAADAFHDTWPLISPWIGAMGAFIAGSNTISNMMFSYFQ
CCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
WSTASQIGLGPDLAAQIVALQAIGGAAGNMVSVHNVVAACAVVGLVNKEGYVIRKTLVAM
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TYYVVQAGFLGMALIFGNIMWWMMAVAWPIGFLVIMSLTTKGAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYTFLALTPILAVFLLLVVLRLPAKIAMSLTFVITALLSLLVWHTSSAQVAAASLNGVIV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHH
ALTILFIVFAAILLLNTLTESGAIIAIRRGFMDISPDRRVQAIIVGWLFCSLVEGSSGFG
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
TPSAVGAPLLLALGFPAMASVMVMLIIQSTPVSFGAVGTPLLVGVWSGIEGKQDLTQSIA
CCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHC
PMSPENYLLQITANVGLLHALIGVLIPLILSAFLTRFFGEKRSFIEGLKVWPFALFAGIC
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FTLPYYLVAKYLGPEFPSLVGGFIGLMIVVPAAKRGFLMPKETFDFGPRAAWDKDWVGTL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCCCCCHHCCCCCCCCCCCHHHHHH
AEEKYDDTVAPRFSIGRAFSPYIIVIALLILTRVIAPLKAFLVGDSATLTISNLFGTEIS
HHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCC
SKIQLLYSPGSILIITSLLCVWLYKMDGASVKRSWSGSAKTMMAAAPALLFSVPMVQVFI
CCEEEEECCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
NSGSTADLATSLPAMPILLAQSAADAFHDTWPLISPWIGAMGAFIAGSNTISNMMFSYFQ
CCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
WSTASQIGLGPDLAAQIVALQAIGGAAGNMVSVHNVVAACAVVGLVNKEGYVIRKTLVAM
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TYYVVQAGFLGMALIFGNIMWWMMAVAWPIGFLVIMSLTTKGAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]