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The map label for this gene is gacA [H]

Identifier: 148653231

GI number: 148653231

Start: 1752505

End: 1753140

Strand: Direct

Name: gacA [H]

Synonym: PsycPRwf_1429

Alternate gene names: 148653231

Gene position: 1752505-1753140 (Clockwise)

Preceding gene: 148653229

Following gene: 148653235

Centisome position: 58.83

GC content: 42.61

Gene sequence:

>636_bases
ATGATTAAAGTTTTGGTGGTTGATGATCATGACCTCGTAAGAATGGGGATTAGTAGAATGCTCGCTGACGACCCCGAGAT
TGAAGTAATAGGTGAGGCTGATAGTGGCGAAGCTGCGATTAGAATGGTTAAAGCGCTATCCCCAGATGTGGTACTCTTAG
ATGTAAACATGCCTAATATTGGCGGTGTAGAAACCACAAAACGCTTGCGTCAATTTGATGAAAAGGTAAAAATATTAGCG
GTCAGTAGTGTCTCCTCACAGCCCTACCCCTCTATGTTATTAAAGGCGGGGGTTAATGGCTACATTACCAAAGGTACACC
ACTTGATGAGATGATTAAAGCCATTAAAAAAGTGTATCAAGGCAGCAAGTACTTTAGCAGTGATGTCGCTGAGCAGTTGG
CCGATATGCTACTGACAGACAATGAAGAATCCCCTTTTGATAGATTAAGCGAGCGCGAAAAACAAGTGGCAATGATGGTA
GTCAACTGTCAAAGCCCGCAGCAAATAGCCGATCAGCTTTTTGTGAGCGTAAAAACTGTTAACACTTATCGCTACCGAAT
TTTTGAAAAAGTCGGTGTCGACAGTGATGTAAAACTCACTCATTTAGCAATGCGTCATGGACTGATTACCCCTTAA

Upstream 100 bases:

>100_bases
TGGGATTAAGGTATGTTGTCAATTCAAAACATTCCTTTTACGCTACAGTAACATAAAAATACTGGTATCATAGCTTTATA
AGTTTTTTTAGGATGTATAT

Downstream 100 bases:

>100_bases
CGCTGCCATGTGGCTATTTTGGCTAAAATCTATAAAAATCTCAATATAATCAAAAGCCGCTAATCTATTAGCGGCTGTTT
TTATAATTTCTGGCTGTGAT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Global activator [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MIKVLVVDDHDLVRMGISRMLADDPEIEVIGEADSGEAAIRMVKALSPDVVLLDVNMPNIGGVETTKRLRQFDEKVKILA
VSSVSSQPYPSMLLKAGVNGYITKGTPLDEMIKAIKKVYQGSKYFSSDVAEQLADMLLTDNEESPFDRLSEREKQVAMMV
VNCQSPQQIADQLFVSVKTVNTYRYRIFEKVGVDSDVKLTHLAMRHGLITP

Sequences:

>Translated_211_residues
MIKVLVVDDHDLVRMGISRMLADDPEIEVIGEADSGEAAIRMVKALSPDVVLLDVNMPNIGGVETTKRLRQFDEKVKILA
VSSVSSQPYPSMLLKAGVNGYITKGTPLDEMIKAIKKVYQGSKYFSSDVAEQLADMLLTDNEESPFDRLSEREKQVAMMV
VNCQSPQQIADQLFVSVKTVNTYRYRIFEKVGVDSDVKLTHLAMRHGLITP
>Mature_211_residues
MIKVLVVDDHDLVRMGISRMLADDPEIEVIGEADSGEAAIRMVKALSPDVVLLDVNMPNIGGVETTKRLRQFDEKVKILA
VSSVSSQPYPSMLLKAGVNGYITKGTPLDEMIKAIKKVYQGSKYFSSDVAEQLADMLLTDNEESPFDRLSEREKQVAMMV
VNCQSPQQIADQLFVSVKTVNTYRYRIFEKVGVDSDVKLTHLAMRHGLITP

Specific function: Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=45.933014354067, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1788521, Length=207, Percent_Identity=35.7487922705314, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=32.5, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1786747, Length=206, Percent_Identity=28.1553398058252, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788712, Length=205, Percent_Identity=29.2682926829268, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=29.1208791208791, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=24.5098039215686, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23477; Mature: 23477

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLVVDDHDLVRMGISRMLADDPEIEVIGEADSGEAAIRMVKALSPDVVLLDVNMPNI
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GGVETTKRLRQFDEKVKILAVSSVSSQPYPSMLLKAGVNGYITKGTPLDEMIKAIKKVYQ
CCHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHC
GSKYFSSDVAEQLADMLLTDNEESPFDRLSEREKQVAMMVVNCQSPQQIADQLFVSVKTV
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHH
NTYRYRIFEKVGVDSDVKLTHLAMRHGLITP
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MIKVLVVDDHDLVRMGISRMLADDPEIEVIGEADSGEAAIRMVKALSPDVVLLDVNMPNI
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GGVETTKRLRQFDEKVKILAVSSVSSQPYPSMLLKAGVNGYITKGTPLDEMIKAIKKVYQ
CCHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHC
GSKYFSSDVAEQLADMLLTDNEESPFDRLSEREKQVAMMVVNCQSPQQIADQLFVSVKTV
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHH
NTYRYRIFEKVGVDSDVKLTHLAMRHGLITP
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9159518; 10984043 [H]