Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 148653184

GI number: 148653184

Start: 1695390

End: 1697294

Strand: Direct

Name: ilvD [H]

Synonym: PsycPRwf_1382

Alternate gene names: 148653184

Gene position: 1695390-1697294 (Clockwise)

Preceding gene: 148653183

Following gene: 148653186

Centisome position: 56.91

GC content: 51.92

Gene sequence:

>1905_bases
ATGCAATACCGCTCTAAGACCTCAACTTCAGGCCGCAATATGGCTGGTGCCCGTGCATTATGGCGTGCCACAGGTATGAC
TGATGGTGACTTTGATAAGCCAATTATCGCCATTGCCAACTCCTTCACCCAGTTTGTTCCAGGTCACGTCCATCTAAAAG
ACATGGGCCAACTGGTTGCCCGTGAGATTGAGCGTGTGGGCGGGGTTGCCAAAGAATTTAACACCATCGCGGTCGATGAT
GGCATTGCCATGGGTCACAGCGGTATGCTGTACTCCTTGCCAAGCCGTGACTTAATCGCAGATTCTGTAGAGTATATGGT
CAATGCCCACTGCGCAGATGCGTTAGTATGTATCTCAAACTGCGACAAAATCACCCCAGGTATGTTAATGGCAGCCATGC
GCCTAAACATCCCAGTTATCTTTGTCTCAGGTGGCCCTATGGAGGCCGGCAAGGTATTGGCTGAAGATTTAGCGCCCAGT
CATAATCTTGATGCCCCCGTCAATGAAGATGGCAAAAAAATCCGTAAGCTAGATCTTGTGGATGCCATGATTGACGCCGC
TGATGACAACGTAAGCGATGCTGACGTGTTAGAGATTGAGCGCTCCGCTTGCCCAACGTGCGGCTCATGCTCAGGCATGT
TCACCGCCAACTCAATGAACTGCTTAACCGAAGCCTTAGGTCTATCTTTGCCCGGTAACGGTTCATTGCTAGCCACTCAT
GCCAAGCGTGAAGCCCTGTTCTTAGAAGCCGGTCGCCGTATTGTTGATTTAGCAAAACGCCGCTATGAGCAGGACGATGA
GTCAACCCTGCCCCGCTCTATTGCCACCAAAGAAGCCTTTGAAAACGCCATGAGCCTTGATATCGCCATGGGCGGCTCAA
CCAATACCATCTTGCATTTATTGGCCGCTGCGCATGAAGCGGAAGTTGACTTTAAAATGGCCGATATCGACCAGTTAAGT
CGCCGCGTGCCTTGCTTATCAAAAGTGGCGCCTGCTACCCAAAAATACCATATGGAAGATGTGCACCGTGCCGGCGGGGT
ATTGGCAATTTTGGCCGAGCTAAATCGTGCCGGTCTATTGCACACAAACTTGCCAACCGTTCACGCCAAGACCTTGCAAG
AAGCGCTTGAGATGTGGGATGTGATGAATACTGATCATCCCAATCATGAAGCGGCACGTGATTTGTATATCGCAGCACCA
GGCGGCGTACGTACCACCCAAGCTTTCTCACAAAATAAAGCCTGGTCCAATCTGGATCTAAACCGTGAGTCTGGCTGTAT
CCGCTCTGCCGAGCATGCTTATTCTAAAGACGGCGGTCTGGCCGTATTGTTCGGTAACATTGCTGAGCGTGGCTGCGTGG
TAAAAACTGCTGGCGTTGATGACAGCATCCTAACCTTCACTGGCCGTGCCCGTGTGTTTGAGTCACAAGATGATGCCGTA
GAGGCCATCTTGGCGGACAAAGTCGTGGCCGGTGATATTGTCATTATCCGTTATGAAGGCCCGAAAGGTGGCCCGGGCAT
GCAAGAGATGCTCTACCCGACTTCTTACTTAAAATCAAAAGGCTTGGGTAAAGAGTGTGCGCTATTAACCGATGGCCGCT
TTTCTGGGGGCACCTCGGGTCTATCAATCGGCCATGCCAGCCCGGAAGCTGCCGAAGGTGGCGCTATTGGTCTAGTAAAT
GAGGGTGATACCATCCACATCGACATTCCAAATCGCAGCATTAACCTGGAGGTCTCTGACAGTGAGCTTGCCCGCCGCCG
TGAAGAGATGGAAGCACGTGGTAGCAAAGCTTGGAAACCTGAAAGTCGCGAGCGCCATGTCAGTCAAGCCCTACGTGCCT
ACGCCGCCATGACCACCAGCGCGGATACCGGTGCGGTACGTGACGTGAGTCAAGTTGAACGTTAA

Upstream 100 bases:

>100_bases
AATTTATACTTAATCAATATTTTTTGCTTTAACCAAATCTGTGTTTATAGGTTACAATACCTATTGAGTAATTCAATACC
TAAGATAAAAAGGATGTTAT

Downstream 100 bases:

>100_bases
TACGCTGTAAAATGAATAAAAACTCAAAAAAAAGCCAGCCGATGCTGGCTTTTTTTGTACAGTGTTAGGCCACAGCTTAT
TTTAGGCCAGACGCTAATGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MQYRSKTSTSGRNMAGARALWRATGMTDGDFDKPIIAIANSFTQFVPGHVHLKDMGQLVAREIERVGGVAKEFNTIAVDD
GIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVLAEDLAPS
HNLDAPVNEDGKKIRKLDLVDAMIDAADDNVSDADVLEIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATH
AKREALFLEAGRRIVDLAKRRYEQDDESTLPRSIATKEAFENAMSLDIAMGGSTNTILHLLAAAHEAEVDFKMADIDQLS
RRVPCLSKVAPATQKYHMEDVHRAGGVLAILAELNRAGLLHTNLPTVHAKTLQEALEMWDVMNTDHPNHEAARDLYIAAP
GGVRTTQAFSQNKAWSNLDLNRESGCIRSAEHAYSKDGGLAVLFGNIAERGCVVKTAGVDDSILTFTGRARVFESQDDAV
EAILADKVVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLVN
EGDTIHIDIPNRSINLEVSDSELARRREEMEARGSKAWKPESRERHVSQALRAYAAMTTSADTGAVRDVSQVER

Sequences:

>Translated_634_residues
MQYRSKTSTSGRNMAGARALWRATGMTDGDFDKPIIAIANSFTQFVPGHVHLKDMGQLVAREIERVGGVAKEFNTIAVDD
GIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVLAEDLAPS
HNLDAPVNEDGKKIRKLDLVDAMIDAADDNVSDADVLEIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATH
AKREALFLEAGRRIVDLAKRRYEQDDESTLPRSIATKEAFENAMSLDIAMGGSTNTILHLLAAAHEAEVDFKMADIDQLS
RRVPCLSKVAPATQKYHMEDVHRAGGVLAILAELNRAGLLHTNLPTVHAKTLQEALEMWDVMNTDHPNHEAARDLYIAAP
GGVRTTQAFSQNKAWSNLDLNRESGCIRSAEHAYSKDGGLAVLFGNIAERGCVVKTAGVDDSILTFTGRARVFESQDDAV
EAILADKVVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLVN
EGDTIHIDIPNRSINLEVSDSELARRREEMEARGSKAWKPESRERHVSQALRAYAAMTTSADTGAVRDVSQVER
>Mature_634_residues
MQYRSKTSTSGRNMAGARALWRATGMTDGDFDKPIIAIANSFTQFVPGHVHLKDMGQLVAREIERVGGVAKEFNTIAVDD
GIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVLAEDLAPS
HNLDAPVNEDGKKIRKLDLVDAMIDAADDNVSDADVLEIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATH
AKREALFLEAGRRIVDLAKRRYEQDDESTLPRSIATKEAFENAMSLDIAMGGSTNTILHLLAAAHEAEVDFKMADIDQLS
RRVPCLSKVAPATQKYHMEDVHRAGGVLAILAELNRAGLLHTNLPTVHAKTLQEALEMWDVMNTDHPNHEAARDLYIAAP
GGVRTTQAFSQNKAWSNLDLNRESGCIRSAEHAYSKDGGLAVLFGNIAERGCVVKTAGVDDSILTFTGRARVFESQDDAV
EAILADKVVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIGLVN
EGDTIHIDIPNRSINLEVSDSELARRREEMEARGSKAWKPESRERHVSQALRAYAAMTTSADTGAVRDVSQVER

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=631, Percent_Identity=73.6925515055468, Blast_Score=960, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=539, Percent_Identity=32.0964749536178, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=583, Percent_Identity=30.5317324185249, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1788157, Length=561, Percent_Identity=28.1639928698752, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=625, Percent_Identity=36.64, Blast_Score=352, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 68051; Mature: 68051

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYRSKTSTSGRNMAGARALWRATGMTDGDFDKPIIAIANSFTQFVPGHVHLKDMGQLVA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHH
REIERVGGVAKEFNTIAVDDGIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISN
HHHHHHCCHHHHCCEEEECCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
CDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVLAEDLAPSHNLDAPVNEDGKKIRKLDLV
CCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
DAMIDAADDNVSDADVLEIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATH
HHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEC
AKREALFLEAGRRIVDLAKRRYEQDDESTLPRSIATKEAFENAMSLDIAMGGSTNTILHL
HHHHHHHHHHCHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHEEEEEECCCHHHHHHH
LAAAHEAEVDFKMADIDQLSRRVPCLSKVAPATQKYHMEDVHRAGGVLAILAELNRAGLL
HHHHHHCCCCEEECCHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
HTNLPTVHAKTLQEALEMWDVMNTDHPNHEAARDLYIAAPGGVRTTQAFSQNKAWSNLDL
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCCCHHHHHHCCCCCCCCCC
NRESGCIRSAEHAYSKDGGLAVLFGNIAERGCVVKTAGVDDSILTFTGRARVFESQDDAV
CCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEECCEEEECCCHHHH
EAILADKVVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSG
HHHHHHHEEECCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCC
LSIGHASPEAAEGGAIGLVNEGDTIHIDIPNRSINLEVSDSELARRREEMEARGSKAWKP
CCCCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCC
ESRERHVSQALRAYAAMTTSADTGAVRDVSQVER
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MQYRSKTSTSGRNMAGARALWRATGMTDGDFDKPIIAIANSFTQFVPGHVHLKDMGQLVA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHH
REIERVGGVAKEFNTIAVDDGIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISN
HHHHHHCCHHHHCCEEEECCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
CDKITPGMLMAAMRLNIPVIFVSGGPMEAGKVLAEDLAPSHNLDAPVNEDGKKIRKLDLV
CCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
DAMIDAADDNVSDADVLEIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATH
HHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEC
AKREALFLEAGRRIVDLAKRRYEQDDESTLPRSIATKEAFENAMSLDIAMGGSTNTILHL
HHHHHHHHHHCHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHEEEEEECCCHHHHHHH
LAAAHEAEVDFKMADIDQLSRRVPCLSKVAPATQKYHMEDVHRAGGVLAILAELNRAGLL
HHHHHHCCCCEEECCHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEE
HTNLPTVHAKTLQEALEMWDVMNTDHPNHEAARDLYIAAPGGVRTTQAFSQNKAWSNLDL
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCCCHHHHHHCCCCCCCCCC
NRESGCIRSAEHAYSKDGGLAVLFGNIAERGCVVKTAGVDDSILTFTGRARVFESQDDAV
CCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEECCEEEECCCHHHH
EAILADKVVAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECALLTDGRFSGGTSG
HHHHHHHEEECCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCC
LSIGHASPEAAEGGAIGLVNEGDTIHIDIPNRSINLEVSDSELARRREEMEARGSKAWKP
CCCCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCC
ESRERHVSQALRAYAAMTTSADTGAVRDVSQVER
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA