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The map label for this gene is hpt [H]

Identifier: 148653016

GI number: 148653016

Start: 1481037

End: 1481603

Strand: Direct

Name: hpt [H]

Synonym: PsycPRwf_1210

Alternate gene names: 148653016

Gene position: 1481037-1481603 (Clockwise)

Preceding gene: 148653015

Following gene: 148653022

Centisome position: 49.72

GC content: 42.15

Gene sequence:

>567_bases
ATGAGCCAAATCAGCAATCAAGAAATCGAGAAAACACTACGCAATTCAGAATGCTTAATCAGTAGCATTGAAGTGGCTGC
TGCTTATGAGCGCCTGGCTGCTCAATTAAACCTACATTATGCAGGCCTAAACCCAATTGTTATGGTCGTTATGAATGGTG
GCTTGATTCCAGCCGGTCAACTTCTGACCCACCTAACCTTCTACCATCGTATGCATTACATCCACGCAACTCGCTATCGT
GACAACCAAGGTACCAATGAATTAATGTGGGCTTTTAAGCCAGACGTTAACATTGAAGGCGAGCATGTGCTTTTAATTGA
TGATATTTTTGATGAAGGCATCACGTTAAAGGCTATCGTACAAGAGCTGAAAAAAGAAAACCCAGCGTCAGTAGATTGCT
GTGTGCTACTAAATAAGAAGCATGATCGCAAAGTAGAAGGCTTCAACGTAGATTTCGTTGGTTTGGATGTTGACGACCGC
TATGTTTACGGCTGTGGTATGGATTTTCATGGTTATTTACGTCATCTTCCTGGCATCTATGCCATCAAAGAAGACAAACT
GCCTTAA

Upstream 100 bases:

>100_bases
AAAGCAGTAAATATTGATGGATAGCGTTAACAGGGTTGGCTCAAATTGGCTAATCCTGTTAAAATAGATCCTTTCAACAA
AATAACTGCGTGTCCTTACT

Downstream 100 bases:

>100_bases
TTGAAATACCCTATCAATTAACCAGTCTTTTAACTCAAAAGCACCTATATAGGTGCTTTTTTGTGCCGAAAACTTAGTCG
CTTTAATATTTAATCAACAG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQLLTHLTFYHRMHYIHATRYR
DNQGTNELMWAFKPDVNIEGEHVLLIDDIFDEGITLKAIVQELKKENPASVDCCVLLNKKHDRKVEGFNVDFVGLDVDDR
YVYGCGMDFHGYLRHLPGIYAIKEDKLP

Sequences:

>Translated_188_residues
MSQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQLLTHLTFYHRMHYIHATRYR
DNQGTNELMWAFKPDVNIEGEHVLLIDDIFDEGITLKAIVQELKKENPASVDCCVLLNKKHDRKVEGFNVDFVGLDVDDR
YVYGCGMDFHGYLRHLPGIYAIKEDKLP
>Mature_187_residues
SQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQLLTHLTFYHRMHYIHATRYRD
NQGTNELMWAFKPDVNIEGEHVLLIDDIFDEGITLKAIVQELKKENPASVDCCVLLNKKHDRKVEGFNVDFVGLDVDDRY
VYGCGMDFHGYLRHLPGIYAIKEDKLP

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=165, Percent_Identity=27.8787878787879, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI9910262, Length=165, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=28.9156626506024, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21375; Mature: 21244

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQ
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCHHH
LLTHLTFYHRMHYIHATRYRDNQGTNELMWAFKPDVNIEGEHVLLIDDIFDEGITLKAIV
HHHHHHHHHHHHHHHEEEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHH
QELKKENPASVDCCVLLNKKHDRKVEGFNVDFVGLDVDDRYVYGCGMDFHGYLRHLPGIY
HHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCEE
AIKEDKLP
EEECCCCC
>Mature Secondary Structure 
SQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQ
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCHHH
LLTHLTFYHRMHYIHATRYRDNQGTNELMWAFKPDVNIEGEHVLLIDDIFDEGITLKAIV
HHHHHHHHHHHHHHHEEEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHH
QELKKENPASVDCCVLLNKKHDRKVEGFNVDFVGLDVDDRYVYGCGMDFHGYLRHLPGIY
HHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCCEE
AIKEDKLP
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]