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The map label for this gene is fadH [C]

Identifier: 148652976

GI number: 148652976

Start: 1432369

End: 1433640

Strand: Direct

Name: fadH [C]

Synonym: PsycPRwf_1170

Alternate gene names: 148652976

Gene position: 1432369-1433640 (Clockwise)

Preceding gene: 148652975

Following gene: 148652980

Centisome position: 48.08

GC content: 46.31

Gene sequence:

>1272_bases
ATGAAAGCTACCCATAATACCCCTGATAACAGTCGTCCCCATGATAATTTACTCAACCAACCTTTAACTCTGCCCAATGG
CACCGTTATCAACAATCGTCTTGCAAAATCTGCAACTAGTGAGACGTTGGCGACTTATAGCAACAACCCTACTCAAGATT
TGGTTCGGCTATATAGACGCTGGGCTGCTTCTGGTATCGGTATGATCATTACGGGTAATATTATGATTGATCGCCAAGCG
TTAGGTGAGCCTGGTAATGTGGTTATTGAGGATGAGCGCGATTTGTCCATATTACAGCAATGGGCCAGTGCAGTGACAAC
GCAGGGTTCTCAGCTTTGGGCACAGTTAAATCACCCTGGCAAGCAAGCCCCAAAAGGACTTAATACGCGCACCATATCAG
CCTCTGCTGTACCCTTTAGCAAGGAGACACAATCCCTATTTGCTACCCCTGAGGCTGCAACTGAGGCGGATATTGCTGAT
ATCATCAAGCGTTTTGGGCGTAGTGCCGCCATCTGTCAAAAAGCAGGCTTTAGTGGGGTACAAATTCATGCGGCTCATGG
CTATTTGCTCAGTCAATTTCTATCTCCCCACCACAATATTCGTGATGATGCTTGGGGAGGTAGTTCTGCCAAACGCCAAC
GTCTTTTATTAGAGGTGTATCATGAGATCCGTCGACAAGTTGGGCCTGACTACCCTATTGCCATTAAATTAAATTCGGCT
GACTTTCAAAAAGGCGGATTTACTGAAGAGGAGTCTTTGGCGGTCATCGAGGCGCTAACAGCGGCAGGGATTGACCTTAT
TGAAATATCAGGCGGTACTTATGAGACTGGAATAGCCAAGGCACAAAAAGCATCGACCATCGCTCGAGAGGCATTCTTTT
TGGAATTTGCTGAAAAGGTACGAAAACAGGTTGATACGCCATTGATGGTCACAGGCGGCTTTAAAAGCTATCAAGGCATG
AATAATGCTTTGTCATCTGGGGCGTTAGATATGGTGGGTATTGGCAGGCTGATGACGATTGATCCTGATGCGCCACAGCA
GCTATTACAAGGCCGTGATAGTGCTCATACGGTAAAACCAATCAAAGTGGGCATCAAGATGATTGATAATCTTGGGGTGA
TGGATGTATTTTGGTACACCGAGCAAATTAAGCGCATTGCTCGAGGAGAGGATCCTAAGCCGAATGAAAGCGCCTTATGC
GCCTTTATCCGAATGATATTCAAAAGTGGATGGGGTACTTTTAGCACGCGGCGTTTACGAGCAAAGTCCTAA

Upstream 100 bases:

>100_bases
CTTATCTTTAATAGTAAGGCTACTTGTCATAGCCCTTTCACTTTAGCACCTTTATTAACCCGTCACTTCTTCTACTTACT
CAATCTTTAAGAGACATTGT

Downstream 100 bases:

>100_bases
GCGCTCACATTCACAAGATTGGTCATCAATGCTGCCGGCTAATGGCGCGTTTACCAATCTCTATCCCTGTATTTTTATCA
ATGACCACAGGCTTTATTTC

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKATHNTPDNSRPHDNLLNQPLTLPNGTVINNRLAKSATSETLATYSNNPTQDLVRLYRRWAASGIGMIITGNIMIDRQA
LGEPGNVVIEDERDLSILQQWASAVTTQGSQLWAQLNHPGKQAPKGLNTRTISASAVPFSKETQSLFATPEAATEADIAD
IIKRFGRSAAICQKAGFSGVQIHAAHGYLLSQFLSPHHNIRDDAWGGSSAKRQRLLLEVYHEIRRQVGPDYPIAIKLNSA
DFQKGGFTEEESLAVIEALTAAGIDLIEISGGTYETGIAKAQKASTIAREAFFLEFAEKVRKQVDTPLMVTGGFKSYQGM
NNALSSGALDMVGIGRLMTIDPDAPQQLLQGRDSAHTVKPIKVGIKMIDNLGVMDVFWYTEQIKRIARGEDPKPNESALC
AFIRMIFKSGWGTFSTRRLRAKS

Sequences:

>Translated_423_residues
MKATHNTPDNSRPHDNLLNQPLTLPNGTVINNRLAKSATSETLATYSNNPTQDLVRLYRRWAASGIGMIITGNIMIDRQA
LGEPGNVVIEDERDLSILQQWASAVTTQGSQLWAQLNHPGKQAPKGLNTRTISASAVPFSKETQSLFATPEAATEADIAD
IIKRFGRSAAICQKAGFSGVQIHAAHGYLLSQFLSPHHNIRDDAWGGSSAKRQRLLLEVYHEIRRQVGPDYPIAIKLNSA
DFQKGGFTEEESLAVIEALTAAGIDLIEISGGTYETGIAKAQKASTIAREAFFLEFAEKVRKQVDTPLMVTGGFKSYQGM
NNALSSGALDMVGIGRLMTIDPDAPQQLLQGRDSAHTVKPIKVGIKMIDNLGVMDVFWYTEQIKRIARGEDPKPNESALC
AFIRMIFKSGWGTFSTRRLRAKS
>Mature_423_residues
MKATHNTPDNSRPHDNLLNQPLTLPNGTVINNRLAKSATSETLATYSNNPTQDLVRLYRRWAASGIGMIITGNIMIDRQA
LGEPGNVVIEDERDLSILQQWASAVTTQGSQLWAQLNHPGKQAPKGLNTRTISASAVPFSKETQSLFATPEAATEADIAD
IIKRFGRSAAICQKAGFSGVQIHAAHGYLLSQFLSPHHNIRDDAWGGSSAKRQRLLLEVYHEIRRQVGPDYPIAIKLNSA
DFQKGGFTEEESLAVIEALTAAGIDLIEISGGTYETGIAKAQKASTIAREAFFLEFAEKVRKQVDTPLMVTGGFKSYQGM
NNALSSGALDMVGIGRLMTIDPDAPQQLLQGRDSAHTVKPIKVGIKMIDNLGVMDVFWYTEQIKRIARGEDPKPNESALC
AFIRMIFKSGWGTFSTRRLRAKS

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=327, Percent_Identity=26.9113149847095, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787939, Length=311, Percent_Identity=28.6173633440514, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17565138, Length=354, Percent_Identity=37.2881355932203, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17540738, Length=352, Percent_Identity=36.9318181818182, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17559802, Length=359, Percent_Identity=36.7688022284123, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17564188, Length=353, Percent_Identity=35.9773371104816, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17559804, Length=353, Percent_Identity=35.4107648725212, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI72001454, Length=351, Percent_Identity=34.7578347578348, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17566914, Length=352, Percent_Identity=33.5227272727273, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17566916, Length=364, Percent_Identity=32.1428571428571, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325086, Length=230, Percent_Identity=30, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321973, Length=380, Percent_Identity=26.0526315789474, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 46275; Mature: 46275

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKATHNTPDNSRPHDNLLNQPLTLPNGTVINNRLAKSATSETLATYSNNPTQDLVRLYRR
CCCCCCCCCCCCCCHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
WAASGIGMIITGNIMIDRQALGEPGNVVIEDERDLSILQQWASAVTTQGSQLWAQLNHPG
HHHCCCCEEEECCEEEEHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
KQAPKGLNTRTISASAVPFSKETQSLFATPEAATEADIADIIKRFGRSAAICQKAGFSGV
CCCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCE
QIHAAHGYLLSQFLSPHHNIRDDAWGGSSAKRQRLLLEVYHEIRRQVGPDYPIAIKLNSA
EEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
DFQKGGFTEEESLAVIEALTAAGIDLIEISGGTYETGIAKAQKASTIAREAFFLEFAEKV
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKQVDTPLMVTGGFKSYQGMNNALSSGALDMVGIGRLMTIDPDAPQQLLQGRDSAHTVKP
HHHCCCCEEEECCCHHHCCHHHHHHCCCCHHEECCEEEEECCCCHHHHHCCCCCCCCCHH
IKVGIKMIDNLGVMDVFWYTEQIKRIARGEDPKPNESALCAFIRMIFKSGWGTFSTRRLR
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
AKS
CCC
>Mature Secondary Structure
MKATHNTPDNSRPHDNLLNQPLTLPNGTVINNRLAKSATSETLATYSNNPTQDLVRLYRR
CCCCCCCCCCCCCCHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
WAASGIGMIITGNIMIDRQALGEPGNVVIEDERDLSILQQWASAVTTQGSQLWAQLNHPG
HHHCCCCEEEECCEEEEHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHCCCC
KQAPKGLNTRTISASAVPFSKETQSLFATPEAATEADIADIIKRFGRSAAICQKAGFSGV
CCCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCE
QIHAAHGYLLSQFLSPHHNIRDDAWGGSSAKRQRLLLEVYHEIRRQVGPDYPIAIKLNSA
EEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
DFQKGGFTEEESLAVIEALTAAGIDLIEISGGTYETGIAKAQKASTIAREAFFLEFAEKV
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKQVDTPLMVTGGFKSYQGMNNALSSGALDMVGIGRLMTIDPDAPQQLLQGRDSAHTVKP
HHHCCCCEEEECCCHHHCCHHHHHHCCCCHHEECCEEEEECCCCHHHHHCCCCCCCCCHH
IKVGIKMIDNLGVMDVFWYTEQIKRIARGEDPKPNESALCAFIRMIFKSGWGTFSTRRLR
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
AKS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]